Annals of Clinical Biochemistry

A simpler and more sensitive modified catalytic (bleomycin detectable) iron assay​Mohan M Rajapurkar, Banibrata Mukhopadhyay, Suhas S Lele, Sudhir V Shah129025Muljibhai Patel Urological Hospital, Nadiad, India212215University of Arkansas for Medical Sciences, Little Rock, AR, USAon March 14, 2025 at 4:48 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundIron is ubiquitously distributed in biology, only a miniscule amount exists as free is capable of catalysing production of highly toxic reactive hydroxyl radicle. This free iron also called; labile iron, non-transferrin bound iron or catalytic …

Underreporting of synthetic cathinone poisoning with clinical immunoassays: An experimental and observational study​Théo Willeman, Mathis Laudet, Bruno Revol, Coralie Boudin, Hélène Eysseric-Guerin, Virginie Scolan, Françoise Stanke-Labesque1Laboratoire de Pharmacologie, Pharmacogénétique et Toxicologie, 36724CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France2Clinique de Médecine Légale, 36724CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France3CEIP-Addictovigilance, 36724CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France4Laboratoire HP2 Inserm U1300, 27015University Grenoble Alpes, Grenoble, France5Laboratoire de Médecine Légale, 27015University Grenoble Alpes, Grenoble, Franceon March 22, 2025 at 3:44 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundThere is an increasing global concern about the use of synthetic cathinones (SCs). Detecting these drugs in human urine samples can be difficult, particularly in emergency settings. Cross-reactivity has been described for several immunoassays. …

Sigma metrics for assessing the analytical performance of 14 biochemical analytes in Mansoura university children’s hospital laboratories (MUCHLs) using CLIA LIMITS 1988 & 2024​Nada Karam, Reham M El-Farahaty, Abdel- Hady El-Gilany, Nessma A Nosser1Clinical Pathology Department, Faculty of Medicine, 68780Mansoura University, Mansoura, Egypt2Public Health & Preventive Medicine, Faculty of Medicine, 68780Mansoura University, Mansoura, Egypton March 14, 2025 at 4:51 am

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Annals of Clinical Biochemistry, Ahead of Print. IntroductionAnalytical quality is a crucial prerequisite for best practice in medical laboratory. Six-Sigma Methodology (SM) is a quality measurement tool used to evaluate laboratory performance. This study aims to assess the analytical phase baseline …

Comparison of three blood collection tubes for 16 biochemical analytes and stability assessment of selected analytes: VACUETTE® CAT serum Sep clot activator tube, VACUETTE® LH lithium heparin Sep tube, and VACUETTE® CAT serum fast separator tube​Jong Do Seo, Yeon Jae Lee, Changhee Ha, Ju Hee Choi, Seon-Hyeon Shin, Hye Young Han, Hyun-Joong Kim, Sung Hea Kim, Bum Sung Kim, Hanah Kim, Hee-Won Moon, Mina Hur, Yeo-Min Yun1Department of Laboratory Medicine, 119754Konkuk University Medical Center, Seoul, Korea2Department of Cardiovascular Medicine, 58933Konkuk University School of Medicine, Seoul, Korea3Department of Laboratory Medicine, 58933Konkuk University School of Medicine, Seoul, Koreaon March 25, 2025 at 9:29 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundAnalytical performance of VACUETTE® CAT Serum Fast Separator Tube (SFT; Greiner Bio-One, Austria), recently developed quick-clotting serum separator, was evaluated for correlation and stability, comparing with VACUETTE® CAT Serum Sep Clot …

Decrease in the internal quality control intermediate reproducibility imprecision of Cystatin C results in China in the years from 2014 to 2023​Zhixin Zhang, Jie Zeng, Wei Wang, Yuxuan Du, Shuai Yuan, Na Dong, Chuanbao Zhang, Zhiguo WangNational Center for Clinical Laboratories/Beijing Engineering Research Center of Laboratory Medicine, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, Chinaon March 14, 2025 at 4:39 am

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Annals of Clinical Biochemistry, Ahead of Print. ObjectivesWe evaluated the intermediate reproducibility imprecision of cystatin C results based on internal quality control (IQC) data.MethodsIQC data for cystatin C analyte were collected each year from 2014 to 2023. We used the coefficient of variation (…

Preβ1-high-density lipoprotein binds to TG-rich lipoproteins and its release is impaired in the postprandial state among patients with poorly controlled type 2 diabetes​Yuna Horiuchi, Satoshi Hirayama, Atsushi Hori, Yuri Ichikawa, Satoshi Soda, Utako Seino, Kazumasa Sekihara, Tsuyoshi Ueno, Yoshifumi Fukushima, Katsuo Kubono, Takashi Miida1Department of Clinical Laboratory Technology, 12847Juntendo University Faculty of Medical Science, Urayasu, Japan2Department of Clinical Laboratory Medicine, 12847Juntendo University Graduate School of Medicine, Tokyo, Japan3Health Service Center, Tokyo Gakugei University, Tokyo, Japan4Department of Endocrinology and Metabolism, 26834Niigata City General Hospital, Niigata, Japan5Division of Clinical Laboratory, 679868Misono Hospital, Niigata, Japan6Department of Pharmacology, Faculty of Medicine, 12952University of Miyazaki, Miyazaki, Japanon March 5, 2025 at 2:53 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundAlthough preβ1-high-density lipoprotein (preβ1-HDL) promotes cholesterol efflux, high fasting preβ1-high-density lipoprotein levels after breakfast are reduced in patients with poorly controlled type 2 diabetes.ObjectiveThis study investigated …

Metamizole (dipyrone) as an interferent in biochemical assays​David Ceacero-Marín, Lídia Martínez-Zamorano, Adrían Gisbert-Alonso, Isabel Cachón-Suárez, Karla Gabriela Mendoza-Javier, María José Castro-CastroBiochemistry Core of the Clinical Laboratory, 16383Bellvitge University Hospital, Barcelona, Spainon March 5, 2025 at 2:46 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundMetamizole (MMZ), commonly used as an analgesic/antipyretic in countries like Spain, faces restrictions elsewhere due to side effects. Despite this, its frequent use underscores the critical importance of studying its impact on the accuracy of …

The diagnostic and prognostic value of serum angiopoietin-like 4 level in neonatal respiratory distress syndrome​Xiuyun SongDepartment of Neonatology, 159406Children’s Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, Chinaon January 13, 2025 at 2:36 am

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Annals of Clinical Biochemistry, Ahead of Print. ObjectivesNeonatal respiratory distress syndrome (NRDS) is the most common respiratory disease in preterm infants (PIs). The implication of Angiopoietin-like 4 (ANGPTL4) was reported in lung diseases. We delved into the role of serum ANGPTL4 in NRDS …

Determination of the biological variation and reference change value of lipoprotein (a)​Kofi Antwi, Paul Downie, Wycliffe MbagayaDepartment of Clinical Biochemistry, 1984University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UKon February 26, 2025 at 3:49 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundUnderstanding lipoprotein (a) [Lp(a)] measurement variability is essential in establishing its coronary heart disease (CHD) association, and optimizing assessment and management of atherosclerotic cardiovascular disease (ASCVD) risk. We …

Paediatric reference ranges for plasma chromogranin A​Sofie Lieberoth, Frederik Friis-Hansen, Lennart Friis-Hansen1Department of Clinical Biochemistry, Odense University Hospital, 11286University of Southern Denmark, Odense, Denmark2Department of Clinical Biochemistry, 53166Bispebjerg and Frederiksberg Hospitals, Copenhagen, Denmark3Department of Clinical Research, 11286University of Southern Denmark, Odense, Denmarkon September 15, 2023 at 2:15 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundNeuroendocrine neoplasms (NENs) are a heterogeneous group of rare diseases with varied aggressiveness originating from endocrine cells belonging to the diffuse endocrine system and most often produce and secrete chromogranin A (CgA). CgA in …

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