Annals of Clinical Biochemistry

Determination of the biological variation and reference change value of lipoprotein (a)​Kofi Antwi, Paul Downie, Wycliffe MbagayaDepartment of Clinical Biochemistry, 1984University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UKon February 26, 2025 at 3:49 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundUnderstanding lipoprotein (a) [Lp(a)] measurement variability is essential in establishing its coronary heart disease (CHD) association, and optimizing assessment and management of atherosclerotic cardiovascular disease (ASCVD) risk. We …

Paediatric reference ranges for plasma chromogranin A​Sofie Lieberoth, Frederik Friis-Hansen, Lennart Friis-Hansen1Department of Clinical Biochemistry, Odense University Hospital, 11286University of Southern Denmark, Odense, Denmark2Department of Clinical Biochemistry, 53166Bispebjerg and Frederiksberg Hospitals, Copenhagen, Denmark3Department of Clinical Research, 11286University of Southern Denmark, Odense, Denmarkon September 15, 2023 at 2:15 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundNeuroendocrine neoplasms (NENs) are a heterogeneous group of rare diseases with varied aggressiveness originating from endocrine cells belonging to the diffuse endocrine system and most often produce and secrete chromogranin A (CgA). CgA in …

Exploratory study on reference intervals of calprotectin and pentraxin 3​Igor Alfirevic, Andrea Saracevic, Helena Cicak, Hrvoje Galic, Vanja Radisic Biljak, Ana-Maria Simundic1University Department of Surgery, University Hospital Sveti Duh, Zagreb, Croatia2Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia3University North, Varazdin, Croatia4Department of Medical Laboratory Diagnostics, University Hospital Sveti Duh, Zagreb, Croatia5Faculty of Kinesiology, University of Zagreb, Zagreb, Croatia6Department of Global Medical and Clinical Affairs, 31310Greiner Bio-One, Kremsmünster, Austria7Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatiaon December 9, 2024 at 10:32 am

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Annals of Clinical Biochemistry, Ahead of Print. IntroductionThe aim of our study was to determine reference intervals for serum pentraxin 3 and calprotectin, as well as for urine calprotectin according to the CLSI EP28-A3C guidelines for defining, establishing, and verifying reference intervals in the …

A multicenter study comparing a point-of-care blood glucose metre with a blood gas analyser in infants by the Shikoku Neonatal Medical Research Group​Toru Kuboi, Masashiro Sugino, Takaaki Sadamura, Nana Kawaguchi, Yoko Tadatomo, Kosei Takada, Natsumi Okamoto, Kiwako Miyamoto, Akiko Nakano, Noriko Miura, Yusei Nakata, Kenichi Suga, Masaaki Ota, Shinji Nakamura, Kosuke Koyano, Takashi Kusaka1Department of Neonatology, 36983National Hospital Organization Shikoku Medical Center for Children and Adults, Zentsuji, Japan2Department of Pediatrics, Kochi Medical School, Kochi University, Nankoku, Japan3Department of Pediatrics, 47717Kochi Health Sciences Center, Kochi, Japan4Department of Pediatrics, 163647Tokushima University Hospital, Tokushima, Japan5Department of Pediatrics, 38050Ehime University Graduate School of Medicine, Matsuyama, Japan6Department of Pediatrics, Faculty of Medicine, 12850Kagawa University, Kitagun, Japanon March 1, 2025 at 7:19 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundThere have been no reports on blood glucose metres for measurements in a wide variety of infant patients, from very preterm infants to mature infants and from the early neonatal period onwards. In this study, we evaluated the accuracy of the …

The preliminary study of delta checks for immunoglobulins and complements in the clinical laboratory​Xiangmei Gong, Shukang He, Li Luo, Chunyu Ding, Xin Qin, Yilong Yuan, Pengcheng Cai, Lihua YangDepartment of Clinical Laboratory, Union Hospital, Tongji Medical College, 12443Huazhong University of Science and Technology, Wuhan, Chinaon September 24, 2024 at 10:21 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundTo determine delta check limits for immunoglobulins and complements in outpatients and inpatients based on patient data and biological variation due to the lack of relevant studies.MethodsPatient data for IgA, IgG, IgM, IgE, C3, and C4 from 1 …

Diagnostic accuracy of bone marrow blood evaluation in haemophagocytic lymphohistiocytosis paediatric patients​Elisa Caravaggi, Federico Serana, Mattia Carini, Fabiana Ferrari, Daniela Tregambe, Moira Micheletti, Giovanni Martellosio, Duilio Brugnoni, Roberto Bresciani, Giorgio Biasiotto1Department of Molecular and Translational Medicine, 9297University of Brescia, Brescia, Italy2Highly Specialized Laboratory, 18515ASST Spedali Civili di Brescia, Brescia, Italy3Clinical Chemistry Laboratory, Diagnostic Department, 18515ASST Spedali Civili di Brescia, Brescia, Italy4Pediatrics, Mother’s and Baby’s Health Department, 188700Poliambulanza Foundation Hospital Institute, Brescia, Italyon October 25, 2024 at 2:04 am

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Annals of Clinical Biochemistry, Ahead of Print. IntroductionHaemophagocytic lymphohistiocytosis (HLH) is a rare and serious immunological syndrome that involves a strong activation of cytotoxic T lymphocytes and macrophages. HLH determines a cytokine-mediated tissue injury with a contemporary multi-…

The effects of controlled acute psychological stress on serum cortisol and plasma metanephrine concentrations in healthy subjects​Aaron Vage, Gerard Gormley, Paul K Hamilton1Centre for Medical Education, 1596Queen’s University Belfast, Belfast, UK2Department of Clinical Biochemistry, Belfast Health and Social Care Trust, Belfast, UKon November 18, 2024 at 3:58 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundAs cortisol and metanephrine are involved in the stress response, it is often recommended that individuals are relaxed at the time of venepuncture, however, evidence behind these recommendations is lacking. We investigated the effects of acute …

Simultaneous quantification of serum symmetric dimethylarginine, asymmetric dimethylarginine and creatinine for use in a routine clinical laboratory​David J Marshall, James M Hawley, Brian G KeevilDepartment of Clinical Biochemistry, 5293Manchester University NHS Foundation Trust, Manchester, UKon November 12, 2024 at 5:50 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundSymmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA) are naturally occurring amino acids classed as uraemic toxins by the European Uremic Toxins Work Group. SDMA is principally excreted through the kidneys and is a well-known …

Evaluation of a laboratory reflex testing protocol to detect hypopituitarism in primary care presenting as hypothyroxinaemia​Colleen Flannery, Ana Rakovac, Gerard Boran1Department of Chemical Pathology, 57976Tallaght University Hospital, Dublin, Ireland2Clinical Biochemistry Unit, School of Medicine, Trinity College Dublin, Irelandon November 11, 2024 at 11:13 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundThyroid function tests (TFTs) are routinely requested by general practitioners (GPs) in the clinical biochemistry laboratory. Hypothyroxinaemia (low fT4) accompanied by TSH within the reference interval (RI) is a discordant pattern which is seen …

Coefficients of variation analyses of internal quality control status for blood lead in China from 2015 to 2023​Han Ma, Wei Wang, Na Dong, Jiali Liu, Shuai Yuan, Chuanbao Zhang, Chao Zhang, Jie Zeng, Ying Yan, Zhiguo WangNational Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, 117555Beijing Hospital/National Center of Gerontology, Beijing, P.R. Chinaon November 18, 2024 at 9:59 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundBlood lead test is widely conducted in Chinese laboratories, while the imprecision of blood lead measurement based on internal quality control (IQC) across China has not been comprehensively evaluated nowadays.MethodsUsing the IQC data of blood …

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