Annals of Clinical Biochemistry

In-vitro verification of tolerance limits for biotin interference of routine biochemistry and immunology assays​Kirsty Swallow, Graeme Wild, Ravishankar SargurImmunology Department and Protein Reference Unit, Northern General Hospital, Sheffield, UKon March 25, 2026 at 1:17 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundBiotin is commonly used in many commercial assays. It is known that exogenous biotin can interfere with these tests, however, not all manufacturers have issued warnings or reassurances. Interference can lead to increased or decreased …

Exploring the stability of whole blood samples for remote health care applications towards reliable home-based blood testing​M. H. Elise van Driel, Alan Han, Dirk J. Grünhagen, Christian Ramakers1Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands,2Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlandson February 3, 2026 at 1:41 am

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Annals of Clinical Biochemistry, Ahead of Print. ObjectivesTo evaluate the stability of commonly used biomarkers in whole blood under various storage conditions, in order to assess their suitability for home-based blood collection in remote care settings.MethodsWhole blood samples were stored at 4–8°C, …

Predicting the outcome of short Synacthen test based on baseline cortisol levels: A single-centered retrospective cohort study at a tertiary care hospital in Sri Lanka​Premadasa T, Samarathunga EPA, Sujith EM, Shameela NMF, Basnayaka BMKS, Antonypillai CN, Jayawardana RDP1Department of Chemical Pathology, National Hospital, Kandy, Sri Lanka2Department of Quality Control, National Hospital, Kandy, Sri Lanka3Department of Diabetic and Endocrinology, National Hospital, Kandy, Sri Lankaon September 16, 2025 at 2:39 am

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Annals of Clinical Biochemistry, Ahead of Print. IntroductionShort Synacthen Test (SST), a standard diagnostic test to confirm Adrenal insufficiency (AI), involves substantial expenses.ObjectivesThis study aimed to assess the predictive value of baseline Cortisol levels for SST outcomes and establish …

Evaluation of a point of care prostate-specific antigen blood test on a mobile outreach service​Masood Moghul, Helen Berry, Freeda Millet, Amina Tran, Fiona Mutch, Elizabeth Westaway, Fionnuala Croft, Robyn Shea, Netty Kinsella, Patrick Kierkegaard, Declan Cahill, Nicholas David James1Department of Urology, 4970The Royal Marsden NHS Foundation Trust, London, UK2Division of Radiotherapy and Imaging, 5053The Institute of Cancer Research, London, UK3Cancer Research UK Convergence Science Centre, 4615Imperial College London, London, UKon November 5, 2025 at 10:16 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundPoint of care (POC) tests may improve accessibility and reduce costs of blood tests including in prostate cancer. The Man Van project was a pilot designed to address health inequalities that affect prostate cancer with novel community-based …

Improving the PLASMIC score with the use of RDW-SD in the differential diagnosis for thrombotic thrombocytopenic purpura in Chinese patients​Chi Zhang, Libo Xia, Xuesong Lv, Weixun Sun, Zhigang Xiong, Yang Fei1Department of Laboratory Medicine, 66375Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China2Department of Clinical Laboratory, Changyang Tujia Autonomous County People’s Hospital, Yichang, Chinaon December 15, 2025 at 5:42 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundThis study aimed to identify laboratory parameters that could optimize the PLASMIC score, thereby improving its diagnostic accuracy for thrombotic thrombocytopenic purpura (TTP).MethodsWe performed a retrospective analysis of 136 patients with …

A UK & Ireland national audit of urine acidification​Emma Hughes, Louise Ward, Wassif S Wassif1Department of Clinical Biochemistry, 59633Aberdeen Royal Infirmary, Aberdeen, UK2On Behalf of the Association for Laboratory Medicine, National Clinical Biochemistry Audit Committee, London, UK3Department of Clinical Biochemistry, 575329Bedfordshire Hospitals NHS Foundation Trust, Bedford, UKon December 15, 2025 at 5:41 am

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Annals of Clinical Biochemistry, Ahead of Print. ObjectivesAcidification of urine samples has long been used as a method of preservation to enhance analyte stability. However, there are inherent safety risks to staff and patients when acid preservatives are used. The Association of Laboratory Medicine …

Enhancing laboratory quality through comprehensive risk management and process analysis​Shobha C Ramachandra, Venkatesha Madegowda, Manish Kumar Pandey, Akila Prashant, Kusuma K Shivashankar, Swetha N KempegowdaDepartment of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Indiaon February 3, 2026 at 1:34 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundLaboratory test results are crucial for clinical decisions, but errors at any stage can compromise patient safety. Despite technological advances and quality systems, laboratory processes remain vulnerable, necessitating structured risk …

Establishment of a candidate reference method and verification of reference intervals for serum copper in pregnant and non-pregnant women​Mengyu Xu, YunGang Pu, Tianyue Zhang, Zhenni Liu, Qian Zhang, Weiyan Zhou, Yuhang Deng, Chao Zhang, Hao Zheng, Haijian Zhao, Jiangtao Zhang, Tianjiao Zhang, Jing Wang, Jie Zeng, Chuanbao Zhang1National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, P.R. China2Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China3Laboratory Department, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China4Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China5Department of Clinical Laboratory, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, Chinaon February 9, 2026 at 5:26 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundSerum copper is an essential trace element, and accurate quantification is important for assessing copper status in pregnancy and supporting early clinical interventions. However, current serum copper assays face several challenges, including …

Preanalytical stability of zinc in whole blood serum and plasma tubes as measured by ICP-OES and colourimetry​Kristian Voss Bjerre, Helle Glud Binderup, Mads Nybo, Louise Helskov Jørgensen1Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark2Department of Clinical Biochemistry, 11286Odense University Hospital, Svendborg, Denmarkon September 16, 2025 at 6:36 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundZinc deficiency is a global concern, particularly in low-income countries, but also among vulnerable groups in Western countries, such as children. Diagnosing mild or moderate zinc deficiency is however challenging because of nonspecific …

Inosine attenuates glycolysis in erythrocytes via glucose transporter inhibition​Yukio Kume, Motohiro Ohkubo, Naru NaKatuka, Sayaka Aritake-Okada, Naoyuki Yoshikawa, Teruhiko Yoshida, Hideaki Isago, Makoto Kurano1Department of Clinical Laboratory, 719261The University of Tokyo Hospital, Tokyo, Japan2Graduate School of Health and Social Services, Saitama Prefectural University, Saitama, Japan3Department of Clinical Laboratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japanon March 2, 2026 at 11:35 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundBlood glucose concentrations decrease after blood collection. We recently developed novel blood collection tubes containing inosine added to sodium fluoride (NaF; FI tubes), which effectively inhibits post-collection blood glucose decline. …

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