Annals of Clinical Biochemistry

Thiopurine S-methyltransferase (TPMT) activity cutoffs in the Thai population​Pimonpan Jinda, Pimpun Kitpoka, Wimol Thienphopirak, Suwat Chiawchan, Santirhat Prommas, Rattanaporn Sukprasong, Jiratha Rachanakul, Supaporn Wiwattanakul, Orapa Suteerojntrakool, Chansuda Bongsebandhu-phubhakdi, Therdpong Tempark, Sittiphong Hunthai, Apichaya Puangpetch1Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, 26687Mahidol University, Bangkok, Thailand2Division of Blood bank, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, 26687Mahidol University, Bangkok, Thailand3Department of Pathology, Faculty of Medicine, 37693Srinakharinwirot University, Nakornnayok, Thailand4Division of Ambulatory Pediatrics, Department of Pediatrics, Faculty of Medicine, 65103Chulalongkorn University, Bangkok, Thailand5Center of Excellence in Pediatric Nutrition, Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand6Department of Biotechnology, Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok, Bangkok, Thailandon September 8, 2025 at 12:50 pm

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundThiopurine S-methyltransferase (TPMT) is crucial for metabolizing thiopurine drugs. This study aimed to establish the cutoff values for TPMT activity in a cohort of healthy individuals. We defined normal TPMT activity ranges and identified …

Diagnostic accuracy and rapid testing of a novel acute heart failure biomarker: A laboratory evaluation and comparison with natriuretic peptides​Kevin Rouet, Philippe Rouet, François Koukoui, Michel Galinier1Association pour le Développement de la Recherche en Cardiologie Moléculaire et Clinique, Clermont le Fort, France2Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania3Department of Surgical Oncology, Regional Institute of Oncology (IRO), Iasi, Romania455461Service de Réadaptation Cardiaque Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France5Department of Cardiology, 665182Toulouse University Hospital, Toulouse, Franceon August 29, 2025 at 1:31 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundDiagnosing acute heart failure in patients presenting with acute dyspnea remains challenging. Current methods, including natriuretic peptide measurement and echocardiography, are time-consuming and not always immediately accessible. A novel …

Procalcitonin assay variation in an Australasian external quality assurance program​Alexander Richardson, Kristie Chapman, Peter Graham, Tony Badrick1Royal College of Pathologists of Australasia Quality Assurance Programs, NSW, Australia2Department of Clinical Immunology, 2205Royal Prince Alfred Hospital, NSW, Australiaon August 14, 2025 at 12:54 pm

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Annals of Clinical Biochemistry, Ahead of Print. Sepsis accounts for approximately 20% of global deaths, and early diagnosis is a critical factor in intervention. In 2017, the FDA approved procalcitonin (PCT) to guide antibiotic use for patients with suspected sepsis, and there are recognized intervals …

Quantitative effects of bilirubin photoisomers on the measurement of direct bilirubin by the enzymatic bilirubin oxidase method​Nana Kawaguchi, Kosuke Koyano, Hirosuke Morita, Dk Nur Rosyiidah Apryll Czarina Pengiran Mohamad Fadly, Yuta Shinabe, Yuta Noguchi, Makoto Arioka, Yasuhiro Nakao, Miyo Ozaki, Shinji Nakamura, Sonoko Kondo, Yukihiko Konishi, Toru Kuboi, Hitoshi Okada, Saneyuki Yasuda, Susumu Itoh, Koji Murao, Takashi Kusaka1Division of Neonatology, 36983NHO Shikoku Medical Center for Children and Adults, Kagawa, Japan2Department of Pediatrics, Faculty of Medicine, 12850Kagawa University, Kagawa, Japan3Faculty of Biomedical Science, 483064Universiti Brunei Darussalam, Brunei Darussalam4Department of Clinical Laboratory, Faculty of Medicine, 12850Kagawa University, Kagawa, Japan5Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Kagawa, Japanon July 29, 2025 at 3:36 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundBilirubin photoisomers, generated during phototherapy or incidental light exposure, may interfere with direct bilirubin (DB) measurement using the bilirubin oxidase method. This interference is particularly relevant in neonates, who …

Is there utility in testing IgA-endomysial antibodies in patients with weak-positive or equivocal IgA-tissue transglutaminase antibodies in the diagnosis of coeliac disease? A critique of current NICE guidance (NG20)​Samuel D Brown, Jacqueline Hitchins, Newton ACS Wong, Amy Hayes, Alice Ogden, Adrian Heaps, Philip Bright1Clinical Biochemistry, Royal Sussex County Hospital, Brighton, UK2Clinical Biochemistry, 1984University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK3Department of Cellular Pathology, 1982North Bristol NHS Trust, Bristol, UK4Department of Immunology & Immunogenetics, 1982North Bristol NHS Trust, Bristol, UKon June 11, 2025 at 9:03 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundCurrent coeliac disease (CD) NICE guidelines recommend testing IgA-endomysial antibodies (EMA) following a weak-positive IgA-tissue transglutaminase antibody (tTGA). Outside of patients with very high IgA-tTGA results, a positive IgA-EMA …

Detection of urinary SERPINA4 by electrochemiluminescence immunoassay and development of a diagnostic model for diabetic nephropathy​LiMei Yang, Huan Li, Fei Chen, Hui Zhang, Feng Wang, WenQian Guo, Ying Shen, ZiJie Liu1Yunnan Key Laboratory of Laboratory Medicine, Kunming, China2Department of Clinical Laboratory, 71240The First Affiliated Hospital of Kunming Medical University, Kunming, China3Department of Nephrology, 74621The First People’s Hospital of Yunnan Province, Kunming, China436657Department of Nephrology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Chinaon June 11, 2025 at 9:13 am

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Annals of Clinical Biochemistry, Ahead of Print. Background and objectivesSERPINA4 has been identified as a potential diagnostic biomarker for diabetic nephropathy (DN) in our previous research. This study aims to develop electrochemiluminescence immunoassay (ECLIA) methods for the detection of SERPINA4 …

Relationships of serum levels of tocilizumab to interleukin-6 and endogenous markers of CYP3A activity in patients with rheumatoid arthritis​Takashi Mochizuki, Kaito Shibata, Takafumi Naito, Kumiko Shimoyama, Noriyoshi Ogawa, Junichi Kawakami1Department of Hospital Pharmacy, 12793Hamamatsu University School of Medicine, Hamamatsu, Japan2Department of Pharmacy, 118108Shinshu University Hospital, Nagano, Japan3Department of Internal Medicine Ⅲ, 12793Hamamatsu University School of Medicine, Hamamatsu, Japanon June 26, 2025 at 1:45 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundTocilizumab co-administration and inflammatory conditions potentially alter the activity of cytochrome P450 (CYP) 3A4 by modulating the interleukin-6 (IL-6) signaling pathway in patients with rheumatoid arthritis (RA). This study aimed to …

A method comparison of the Roche intact PTH method versus the Roche whole PTH (1-84) method: Examining the differences based on eGFR​Byrne E, Twomey PJ, Crowley RK, McKenna MJ, Kilbane M1Department of Clinical Chemistry, 58038St. Vincent’s University Hospital, Dublin, Ireland2Department of Endocrinology, 58038St. Vincent’s University Hospital, Dublin, Irelandon June 24, 2025 at 4:55 am

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Annals of Clinical Biochemistry, Ahead of Print. AimThird-generation whole PTH (1-84) parathyroid hormone (PTH) assays do not recognize the PTH 7-84 fragment whereas second-generation (intact) assays detect both 1-84 and 7-84 PTH fragments. This study aimed to compare the second-generation Roche intact …

Establishment of a reference interval for calculated globulin on the Roche platform​Colleen Flannery, Alison Griffin, John Quinn, Clodagh Loughrey, Shari Srinivasan1Department of Chemical Pathology, 57978Beaumont Hospital, Dublin, Ireland2Department of Haematology, 57978Beaumont Hospital, Dublin, Ireland3School of Medicine, Royal College of Surgeons in Ireland, Dublin, Irelandon July 29, 2025 at 3:41 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundCalculated globulin, based on direct measurement of total protein and albumin, can be a useful addition to the routinely requested liver profile. However, a reference interval, established using CLSI EP28-A3c recommended direct methods, is …

Analysis of first-trimester maternal serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels as a potential non-invasive biomarker for fetal aneuploidy and NTDs​Karthick E, Sathya Selvarajan, Dhivya Senthil Kumar, Sowmya K, Sridharan K S1Department of Biochemistry, 204733Sri Ramachandra Institute of Higher Education and Research, Chennai, India2Clinical Biochemistry and Quality Manager, 653410MGM Healthcare, Chennai, India3Department of Laboratory Medicine, 204733Sri Ramachandra Institute of Higher Education and Research, Chennai, Indiaon July 29, 2025 at 3:40 am

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Annals of Clinical Biochemistry, Ahead of Print. ObjectivesChromosomal abnormalities and congenital anomalies have huge impact on infant mortality and morbidity. The combined incidence affects approximately 1 per 1000 pregnancies. Current diagnostic modalities include ultrasonography and biomarkers like …

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