Monitoring free plasma hemoglobin in ECMO patients: a two-center comparative study of second-derivative spectrophotometry and hemolysis indexes​​on August 17, 2025 at 12:52 pm

Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): Théo Sharaiha, Nolan Pellecuier, Sandrine Dabernat, Fouzi Mestari, Brigitte Colombiès, Emmanuel Richard, Rana Alkouri, Dominique Bonnefont-Rousselot, Benoit Rucheton, Marie-Lise Bats

Reference intervals in value-based laboratory medicine: a shift from single-point measurements to metabolic variation-based modelsAbdurrahman Coskunon August 16, 2025 at 10:00 am

Clin Chem Lab Med. 2025 Aug 18. doi: 10.1515/cclm-2025-0763. Online ahead of print. ABSTRACT Laboratory data can be meaningful only when compared with reliable reference data; therefore, the estimation of reliable reference data is just as important as the accurate measurement of measurands in patient samples. Since analyte concentrations in the human body are influenced … Read more

Evaluation of stability and potential interference on the α-thalassaemia early eluting peak and immunochromatographic strip test for α-thalassaemia –SEA carrier screeningWing Kit Lamon August 16, 2025 at 10:00 am

Clin Chem Lab Med. 2025 Aug 18. doi: 10.1515/cclm-2025-0754. Online ahead of print. ABSTRACT OBJECTIVES: α-Thalassaemia screening is crucial for identifying carriers at risk of having offspring with haemoglobin (Hb) Bart’s hydrops fetalis syndrome. This study evaluated the performance of two potential screening methods: the α-thalassaemia early eluting peak (αEEP) identified by high-performance liquid chromatography … Read more

The importance of laboratory medicine in the management of CKD-MBD: insights from the KDIGO 2023 controversies conferenceSamuel D Vasikaranon August 16, 2025 at 10:00 am

Clin Chem Lab Med. 2025 Aug 15. doi: 10.1515/cclm-2025-0802. Online ahead of print. ABSTRACT Laboratory investigations are important in the clinical management and the study of chronic kidney disease-mineral and bone disorder (CKD-MBD)- including CKD-associated osteoporosis. Parathyroid hormone (PTH) is the major hormone in the regulation of bone and calcium balance but is significantly affected … Read more

Analytical and clinical evaluation of an automated high-sensitivity cardiac troponin I assay for whole bloodJin-Xing Yuon August 14, 2025 at 10:00 am

Clin Chem Lab Med. 2025 Aug 15. doi: 10.1515/cclm-2025-0143. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate the performance of the iStar high-sensitivity cardiac troponin I (hs-cTnI) assay, focusing on its sensitivity, precision, linearity, and consistency with plasma samples, and to establish sex-specific 99th percentile upper reference limits. METHODS: The iStar hs-cTnI assay was assessed … Read more

From metabolic profiles to clinical interpretation: multivariate approaches to population-based and personalized reference intervals and reference change valuesAbdurrahman Coskunon August 14, 2025 at 10:00 am

Clin Chem Lab Med. 2025 Aug 15. doi: 10.1515/cclm-2025-0786. Online ahead of print. ABSTRACT Interpretation of laboratory test results is a comparative process that requires reference data. Such data are derived for each analyte separately, without accounting for, the interrelationships among analytes. Physicians use test panels containing multiple analytes to enhance clinical significance and improve … Read more

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