Assay-specific machine-learning models converting insulin to C-peptide or C-peptide index and C-peptide to HOMA2-IR: Single-center retrospective observational study​on September 4, 2025 at 2:43 pm

Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Yuichiro Iwamoto, Tomohiko Kimura, Toshitomo Sugisaki, Kazunori Dan, Hideyuki Iwamoto, Junpei Sanada, Yoshiro Fushimi, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto  

Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol

Clin Chem. 2025 Sep 3:hvaf099. doi: 10.1093/clinchem/hvaf099. Online ahead of print. ABSTRACT BACKGROUND: Direct measurement of low-density lipoprotein cholesterol (LDL-C) is widely used and recommended by professional society guidelines despite its potential limitations in patients with hypertriglyceridemia and low LDL-C. This study evaluated the performance of 3 direct LDL-C (LDL-CD) assays, 2 modern LDL-C calculation … Read more

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