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An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of cortisol in human urineMyriam Otton October 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0522. Online ahead of print. ABSTRACT OBJECTIVES: Precise and accurate determination of urinary cortisol is important for diagnosis and monitoring of cortisol excess and deficiency. To achieve this, a selective and specific, isotope-dilution two-dimensional heart-cut liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based method was developed. METHODS: A novel, two-dimensional … Read more

Optimization and comparison of genomic DNA extraction from whole blood collected in PAXgene blood RNA tube using automated platformsJianlan Youon October 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-1079. Online ahead of print. ABSTRACT OBJECTIVES: With the development of genomic technologies, the isolation of genomic DNA (gDNA) from clinical samples has become more important for both clinical diagnostics and research studies. Blood samples collected in PAXgene Blood RNA Tubes, which are typically used for RNA … Read more

An isotope dilution-liquid-chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of mycophenolic acid in human serum and plasmaTobias Schierscheron October 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2024-0860. Online ahead of print. ABSTRACT OBJECTIVES: A candidate reference measurement procedure (RMP) based on isotope dilution (ID) liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated to accurately measure serum and plasma concentrations of mycophenolic acid (MPA). METHODS: Quantitative nuclear magnetic resonance (qNMR) spectroscopy was utilized … Read more

Discrimination of urine infrared spectral biomarkers for early-stage chronic kidney disease patients using attenuated total reflectance fourier transform infrared spectrometry​on October 17, 2025 at 1:44 pm

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Publication date: 15 January 2026 Source: Clinica Chimica Acta, Volume 579 Author(s): Patipat Rachawangmuang, Patutong Chatchawal, Patcharaporn Tippayawat, Apinya Jusakul, Ratthapol Kraiklang, Worachart Lert-itthiporn, Anuchin Najermploy, Molin Wongwattanakul  

ADORE: the performance characteristics of five automated platforms in the analysis of urinary dysmorphic erythrocytes and pathological castsJolien J Luimstraon October 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0938. Online ahead of print. ABSTRACT OBJECTIVES: Automated urine particle analyzers are increasingly employed in clinical laboratories to standardize urinalysis. These systems can reduce workload, turnaround time and the inter-observer variation. This study aimed to assess the performance of five automated urine particle analyzers in detecting and … Read more

Automated reticulocyte counting: advances, standardization challenges, and clinical accessibilityHongyin Zhouon October 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-1032. Online ahead of print. ABSTRACT With the advent of flow cytometry and dedicated fluorescent dyes in the 1980s, automated reticulocyte enumeration has effectively superseded conventional manual microscopy, dramatically boosting throughput and precision while, through metrics including the immature reticulocyte fraction (IRF) and reticulocyte production index (RPI), … Read more

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