Analysis of first-trimester maternal serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels as a potential non-invasive biomarker for fetal aneuploidy and NTDs​Karthick E, Sathya Selvarajan, Dhivya Senthil Kumar, Sowmya K, Sridharan K S1Department of Biochemistry, 204733Sri Ramachandra Institute of Higher Education and Research, Chennai, India2Clinical Biochemistry and Quality Manager, 653410MGM Healthcare, Chennai, India3Department of Laboratory Medicine, 204733Sri Ramachandra Institute of Higher Education and Research, Chennai, Indiaon July 29, 2025 at 3:40 am

Annals of Clinical Biochemistry, Ahead of Print.
ObjectivesChromosomal abnormalities and congenital anomalies have huge impact on infant mortality and morbidity. The combined incidence affects approximately 1 per 1000 pregnancies. Current diagnostic modalities include ultrasonography and biomarkers like …

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