Establishment of a candidate reference method and verification of reference intervals for serum copper in pregnant and non-pregnant women​Mengyu Xu, YunGang Pu, Tianyue Zhang, Zhenni Liu, Qian Zhang, Weiyan Zhou, Yuhang Deng, Chao Zhang, Hao Zheng, Haijian Zhao, Jiangtao Zhang, Tianjiao Zhang, Jing Wang, Jie Zeng, Chuanbao Zhang1National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, P.R. China2Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China3Laboratory Department, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China4Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China5Department of Clinical Laboratory, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, Chinaon February 9, 2026 at 5:26 am

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundSerum copper is an essential trace element, and accurate quantification is important for assessing copper status in pregnancy and supporting early clinical interventions. However, current serum copper assays face several challenges, including …

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