Relationships of serum levels of tocilizumab to interleukin-6 and endogenous markers of CYP3A activity in patients with rheumatoid arthritis​Takashi Mochizuki, Kaito Shibata, Takafumi Naito, Kumiko Shimoyama, Noriyoshi Ogawa, Junichi Kawakami1Department of Hospital Pharmacy, 12793Hamamatsu University School of Medicine, Hamamatsu, Japan2Department of Pharmacy, 118108Shinshu University Hospital, Nagano, Japan3Department of Internal Medicine Ⅲ, 12793Hamamatsu University School of Medicine, Hamamatsu, Japanon June 26, 2025 at 1:45 am

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Annals of Clinical Biochemistry, Ahead of Print.
BackgroundTocilizumab co-administration and inflammatory conditions potentially alter the activity of cytochrome P450 (CYP) 3A4 by modulating the interleukin-6 (IL-6) signaling pathway in patients with rheumatoid arthritis (RA). This study aimed to …

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