Determination of lipemia acceptance thresholds for 31 immunoassay analytes
Publication date: 1 August 2023Source: Clinica Chimica Acta, Volume 548Author(s): Şerif Ercan, Mustafa Tat
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Quantification of soluble very low-density lipoprotein receptor in human serum using a sandwich enzyme-linked immunosorbent assay
To investigate the regulation of soluble very low-density lipoprotein receptor (sVLDL-R), which is cleaved mostly from the extracellular domain of VLDL-R II, we generated two rat monoclonal antibodies (mAbs) against human sVLDL-R, and used them to develop a sandwich enzyme-linked immunosorbent assay (ELISA) to measure sVLDL-R levels in human serum or plasma. The ELISA had … Read more
Application of analytical performance specifications for urine test strip methods: importance of reflectance signals
Introduction Urinalysis is essential for diagnosing kidney-related medical conditions. Urine test strip analysis serves as an initial and efficient screening method for reflex testing with accurate quantitative methods. Materials and Methods Freshly voided urines (n=206) were analysed using two urine test strip brands on UC-MAX (Menarini) and cobas u 601 (Roche Diagnostics) instruments. Ordinal scale … Read more
Can artificial intelligence replace biochemists? A study comparing interpretation of thyroid function test results by ChatGPT and Google Bard to practising biochemists
Annals of Clinical Biochemistry, Ahead of Print. BackgroundPublic awareness of artificial intelligence (AI) is increasing and this novel technology is being used for a range of everyday tasks and more specialist clinical applications. On a background o…
Biomarkers of endometriosis
Endometriosis is one of the most severe female reproductive disorders, affecting 6–10% of women between 18 and 35. It is a gynaecological condition where endometrial tissue develops and settles outside the uterus. The aetiology of endometriosis is primarily influenced by genetic, epigenetic, and non-genetic variables, making it highly challenging to create a therapeutic therapy explicitly … Read more
Different serum sodium assay, different model for end stage liver disease – sodium scores in patients awaiting liver transplant: A cross-sectional study
Annals of Clinical Biochemistry, Ahead of Print. Introduction and aimsSodium can be measured with direct or indirect methods; abnormal plasma total protein concentration can impact on sodium measured by indirect ion-selective electrodes (ISE). Serum so…
Standardization of Apolipoprotein B, LDL‐Cholesterol, and Non‐HDL‐Cholesterol
John H. Contois, Michel R. Langlois, Christa Cobbaert and Allan D. Sniderman Originally published25 Jul 2023https://doi.org/10.1161/JAHA.123.030405Journal of the American Heart Association. 2023;12:e030405 Abstract ABSTRACT Concern continues about whether the measurement of apolipoprotein B (apoB) is adequately standardized, and therefore, whether apoB should be applied widely in clinical care. This concern is misplaced. Our objective is to … Read more
Calprotectin, a sensitive marker of inflammation, is robustly assessed in plasma from patients with early or established rheumatoid arthritis by use of different laboratory methods
Volume 83, Issue 5, September 2023, Page 330-335.
Evaluating the effectiveness of a new student-centred laboratory training strategy in clinical biochemistry teaching
Abstract Background The error-proneness in the preanalytical and postanalytical stages is higher than that in the analytical stage of the total testing process. However, preanalytical and postanalytical quality management has not received enough attention in medical laboratory education and tests in clinical biochemistry courses. Methods/approach Clinical biochemistry teaching program aim to improve students’ awareness and … Read more
The effectiveness of an automated algorithm as a tool for investigating the cause of anaemia in undiagnosed patients from general practitioners
Annals of Clinical Biochemistry, Volume 60, Issue 4, Page 270-278, July 2023. BackgroundThe Dutch guideline algorithm for the analysis of anaemia in patients of general practitioners (GPs) was programmed in a Clinical Decision Support system (CDS-anaem…