Advancements in Blood Group Genotyping Technology and Clinical Applications

Clin Chem. 2026 Feb 18:hvag008. doi: 10.1093/clinchem/hvag008. Online ahead of print. ABSTRACT BACKGROUND: Blood group typing is essential in transfusion medicine, transplantation, and prenatal care. With the elucidation of the molecular genetics underlying blood group antigens, primarily single-nucleotide variants (SNVs), DNA-based genotyping has emerged as a powerful alternative to serological methods, enabling more accurate and … Read more

Best practice recommendations for laboratory analysis and reporting of cerebrospinal fluid oligoclonal banding and associated tests for multiple sclerosis (MS): a consensus report from the harmonized CSF analysis for MS investigation (hCAMI) subcommittee of the Canadian society of clinical chemists (CSCC)​​on February 17, 2026 at 10:29 am

Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Victoria Higgins, Michelle L. Parker, Basma Ahmed, Vipin Bhayana, Ronald A. Booth, Yu Chen, Christine Collier, Mark S. Freedman, Myriam Gagné, Ola Z. Ismail, Jessica L. Gifford, Joseph Macri, Craig S. Moore, Ashley Newbigging, Lily Olayinka, Ilia Poliakov, Karina Rodriguez-Capote, Raphael Schneider, Simon Thebault, Liju … Read more

The ARRplus: a model for renin-dependent and sex-specific aldosterone cut-offs that improves screening for primary aldosteronismSybille Fuldon February 16, 2026 at 11:00 am

Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2025-1670. Online ahead of print. ABSTRACT OBJECTIVES: Screening for primary aldosteronism (PA) using the aldosterone:renin ratio (ARR) has suboptimal diagnostic accuracy, particularly in females. We assessed whether accuracy could be improved using sex-specific relationships of aldosterone with renin. METHODS: Plasma aldosterone and renin were measured in 442 … Read more

Characterization of STRC Gene Conversions by Nanopore Sequencing

Clin Chem. 2026 Feb 16:hvag004. doi: 10.1093/clinchem/hvag004. Online ahead of print. ABSTRACT BACKGROUND: Biallelic loss-of-function variants of STRC are a frequent cause of mild to moderate nonsyndromic hearing loss. The high (>98%) sequence homology between STRC and its pseudogene STRCP1 poses a significant challenge for accurate interpretation of STRC variants using standard methods. Although STRC-STRCP1 … Read more

Personalized reference intervals based on biological variation for serum bone turnover markers in healthy older adultsYe Qinon February 16, 2026 at 11:00 am

Clin Chem Lab Med. 2026 Feb 12. doi: 10.1515/cclm-2025-1138. Online ahead of print. ABSTRACT OBJECTIVES: The clinical utility of serum bone turnover markers (BTMs) in managing osteoporosis in the elderly is constrained by the absence of personalized reference intervals (prRI) based on biological variation (BV). METHODS: This longitudinal study tracked monthly serum levels of β-CTX, … Read more

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