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Cardiac Troponin Predicts Mortality Post Surgery

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Pauline Anderson September 27, 2023 TOPLINE: Perioperative myocardial injury, reflected by release of high-sensitivity cardiac troponin T, is associated with 30-day mortality after various cardiac surgeries at postoperative prognostic cutoffs higher than proposed in current definitions, new research suggests. METHODOLOGY: TAKEAWAY: IN PRACTICE: “These results provide important novel insights into the association of hs-cTnT with 30-day mortality … Read more

Prostate Cancer Screening Guidelines: To PSA or Not to PSA

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Guidance for Practicing Primary Care Linda Girgis, MDDISCLOSURES  September 26, 2023 In the United States this year, approximately 288,300 men will be newly diagnosed with prostate cancer and about 34,700 men will die from this disease. It is the second leading cause of cancer in men, and one out of every eight men will be diagnosed with this cancer at some … Read more

Scientists reveal mechanistic link between zinc levels and diabetes

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Researchers have identified a mechanistic link between zinc levels in humans and the risk of type 2 diabetes and fatty liver disease. The research, published today as a Reviewed Preprint in eLife, is described by editors as a fundamental study that substantially advances our understanding of the role of zinc in metabolism. The researchers provide solid … Read more

New test for sepsis could save lives in emergency departments, study suggests

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by Aaron Wagner, Pennsylvania State University Sepsis is a life-threatening medical emergency that occurs when an infection causes a chain reaction throughout the body that can lead to the failure of multiple organs in rapid succession. In the United States about 350,000 people die from sepsis each year, according to the Centers for Disease Control and … Read more

Quantification of soluble very low-density lipoprotein receptor in human serum using a sandwich enzyme-linked immunosorbent assay

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To investigate the regulation of soluble very low-density lipoprotein receptor (sVLDL-R), which is cleaved mostly from the extracellular domain of VLDL-R II, we generated two rat monoclonal antibodies (mAbs) against human sVLDL-R, and used them to develop a sandwich enzyme-linked immunosorbent assay (ELISA) to measure sVLDL-R levels in human serum or plasma. The ELISA had … Read more

Application of analytical performance specifications for urine test strip methods: importance of reflectance signals

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Introduction Urinalysis is essential for diagnosing kidney-related medical conditions. Urine test strip analysis serves as an initial and efficient screening method for reflex testing with accurate quantitative methods. Materials and Methods Freshly voided urines (n=206) were analysed using two urine test strip brands on UC-MAX (Menarini) and cobas u 601 (Roche Diagnostics) instruments. Ordinal scale … Read more

Tests that diagnose diseases are less reliable than you’d expect. Here’s why

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You feel unwell, and visit your doctor. They ask some questions and take some blood for testing; a few days later they call to say you have been diagnosed with a disease. What are the chances you actually have the disease? For some common diagnostic tests, the answer is surprisingly low. Few medical tests are 100% accurate. … Read more

Biopsy-free diagnosis of celiac disease in adults shows promising results

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Researchers from the University of Salerno, Italy, have found that a simple blood test for tTG-IgA concentrations could be used as a diagnostic threshold in predicting duodenal villous atrophy, a hallmark of celiac disease. In their paper, “Serum anti-tissue transglutaminase IgA and prediction of duodenal villous atrophy in adults with suspected celiac disease without IgA … Read more

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