Laboratory quality indicators: persistent variability despite international harmonization effortsDiogo Jerônimoon March 3, 2026 at 11:00 am March 3, 2026 Clin Chem Lab Med. 2026 Mar 3. doi: 10.1515/cclm-2026-0076. Online ahead of print. NO ABSTRACT PMID:41774478 | DOI:10.1515/cclm-2026-0076
Discrepancies of results for post infusion levels of extended half-life factor VIII/IX concentrates – a cause of concern, awaiting for solutionArmando Tripodion March 3, 2026 at 11:00 am March 3, 2026 Clin Chem Lab Med. 2026 Mar 3. doi: 10.1515/cclm-2026-0042. Online ahead of print. ABSTRACT Hemophilia A and B are X-linked hemorrhagic disorders, characterized by low/dysfunctional factor (F)VIII or FIX, respectively. …
Read more Assessing precision, bias, and sigma metrics of 22 measurands using Ricos and EFLM specifications and implementation of internal quality control procedure in clinical chemistry laboratoryon March 3, 2026 at 4:25 pm March 3, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Khouloud Hkimi, Sonia Gara
Choosing Wisely Canada recommendations for point of care testing utilization in the acute care setting: Expert-based Delphi consensus from the Canadian Society of Clinical Chemistson March 3, 2026 at 4:25 pm March 3, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Sukhbir Kaur, Saranya Arnoldo, Jennifer Taher, Dana Bailey, Lori Beach, Daniel R. Beriault, Ihssan Bouhtiauy, Miranda Brun, Manal Elnenaei, Yun …
Read more Personalized reference intervals based on biological variation: a critical evaluation of strengths and limitationsAbdurrahman Coskunon March 3, 2026 at 11:00 am March 3, 2026 Clin Chem Lab Med. 2026 Mar 3. doi: 10.1515/cclm-2026-0263. Online ahead of print. NO ABSTRACT PMID:41772938 | DOI:10.1515/cclm-2026-0263
Methodological rigour and transparency are required for genotyping methods in genetic association studieson March 3, 2026 at 12:15 pm March 3, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Aditya K. Panda
Differences in laboratory reporting of thyroglobulin antibody positivity – a national survey across laboratories in the NetherlandsEliane F E Wenstedton March 2, 2026 at 11:00 am March 3, 2026 Clin Chem Lab Med. 2026 Mar 3. doi: 10.1515/cclm-2026-0056. Online ahead of print. NO ABSTRACT PMID:41771274 | DOI:10.1515/cclm-2026-0056
Diagnostic performance evaluation of the Siemens Healthineers Atellica HEMA 580 hematology analyzer for abnormal cell detection and optimization of immature myeloid cell cut-offsVincenzo De Iuliison March 2, 2026 at 11:00 am March 2, 2026 Clin Chem Lab Med. 2026 Mar 3. doi: 10.1515/cclm-2026-0083. Online ahead of print. ABSTRACT OBJECTIVES: We evaluated the diagnostic performance of the Atellica HEMA 580 hematology analyzer for complete blood …
Read more The conventional reference interval model: a historical framework?Werner Wosniokon March 2, 2026 at 11:00 am March 2, 2026 Clin Chem Lab Med. 2026 Mar 2. doi: 10.1515/cclm-2026-0169. Online ahead of print. NO ABSTRACT PMID:41766327 | DOI:10.1515/cclm-2026-0169
Urinary aldosterone and tetrahydroaldosterone by LC-MS/MS with enzymatic hydrolysis: validation and age-stratified reference intervalsIrene Wijbenga-van der Kooion March 1, 2026 at 11:00 am March 2, 2026 Clin Chem Lab Med. 2026 Mar 2. doi: 10.1515/cclm-2025-1679. Online ahead of print. ABSTRACT OBJECTIVES: Primary aldosteronism (PA) is a common cause of secondary hypertension. To address the specificity limits …
Read more Machine learning-based integration of antiphospholipid antibodies for predicting pregnancy outcomes in patients with recurrent spontaneous abortion: a multicenter prospective studyXinli Jiangon March 1, 2026 at 11:00 am March 2, 2026 Clin Chem Lab Med. 2026 Mar 2. doi: 10.1515/cclm-2026-0088. Online ahead of print. ABSTRACT OBJECTIVES: Antiphospholipid antibodies (aPLs) are closely associated with recurrent spontaneous abortion (RSA) and adverse pregnancy outcomes …
Read more Optimising lipoprotein(a) tests: we are almost thereMichel R Langloison March 1, 2026 at 11:00 am March 2, 2026 Clin Chem Lab Med. 2026 Mar 2. doi: 10.1515/cclm-2026-0269. Online ahead of print. NO ABSTRACT PMID:41764779 | DOI:10.1515/cclm-2026-0269
Explainable machine learning framework based on blood biomarkers and routine health information for assistive diagnosis and risk stratification of acute myocardial infarctionon February 28, 2026 at 2:53 pm February 28, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Xinglong Zhu, Ting Wang, Jidong Jiang, Minghui Zhang, Tao Liu, Xiaodong Zhang, Yiqing Wang
Multi-omics biomarkers in cadmium-related lung toxicity and carcinogenesison February 28, 2026 at 2:53 pm February 28, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Khalid Saad Alharbi
EGFR as a biomarker in colorectal Cancer: An electrochemical biosensing approachon February 28, 2026 at 2:53 pm February 28, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Mohammed Khaled Bin Break, Rahamat Unissa Syed, Weiam Hussein, Muhammad Nawaz, Randa Abdeen Hussein Abdalla, Nayla Ahmed Mohammed …
Read more Correction to: Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility? February 27, 2026 Clin Chem. 2026 Feb 27:hvag015. doi: 10.1093/clinchem/hvag015. Online ahead of print. NO ABSTRACT PMID:41758357 | DOI:10.1093/clinchem/hvag015
Umbilical cord mesenchymal stem cell exosomes in breast cancer. False hope or a real solution?on February 27, 2026 at 1:42 pm February 27, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Dana Jammoul, Toros Torossian, Mohamed Issa, May Saab, Chaza Harmouch, Rami Mhanna, Kawthar K. Abla
A Digital PCR Assay for Fetal Fraction Quantification Using Multiplex SNP and Y Chromosome Detection February 26, 2026 Clin Chem. 2026 Feb 26:hvag017. doi: 10.1093/clinchem/hvag017. Online ahead of print. ABSTRACT BACKGROUND: Fetal fraction (FF) quantification is critical for prenatal cell-free DNA screening. Current methods based on Y chromosome …
Read more Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine February 26, 2026 Clin Chem. 2026 Feb 26:hvag014. doi: 10.1093/clinchem/hvag014. Online ahead of print. ABSTRACT BACKGROUND: Clinical laboratory measurements provide essential results for prediction, screening, diagnosing, treating, monitoring, and prognosis of patients. To …
Read more Correction to: Discordance between Cystatin C-Based and Creatinine-Based Estimated Glomerular Filtration Rate and Mortality in the General Population February 26, 2026 Clin Chem. 2026 Feb 26:hvag003. doi: 10.1093/clinchem/hvag003. Online ahead of print. NO ABSTRACT PMID:41740614 | DOI:10.1093/clinchem/hvag003
Urinary free cortisol analyses: Enhancing their clinical performance in Cushing’s syndrome management by means of LC-MS/MSon February 26, 2026 at 12:46 pm February 26, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Ana Rubio, Santiago Tofé, Antonia Barceló
Detection of thyroid hormones T3 and T4 in urine and serum after levothyroxine administration: A pilot study relevant to doping analysison February 26, 2026 at 12:46 pm February 26, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): T. Colpaert, K. Van Uytfanghe, G. T’Sjoen, N. Van Haecke, W. Van Gansbeke, P. Van Renterghem, M. Olijhoek, …
Read more Glycated albumin: detection methods and standardizationon February 26, 2026 at 12:46 pm February 26, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Rui Wu, Tianjiao Zhang, Chuanbao Zhang
Gelsolin as a diagnostic biomarker in non-small cell lung Canceron February 26, 2026 at 12:46 pm February 26, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Imran Kazmi, Shakilur Rahman, Saleh Al Ghamdi, Mohammed Al-Zharani, Tarique Hussain Ashraf, Muhammad Afzal, Fahd A. Nasr, Faisal …
Read more Engineered Bacteria as living detectors of tumor DNA: A new diagnostic frontieron February 26, 2026 at 12:46 pm February 26, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Abdolmajid Ghasemian, Ali H. Al-Marzoqi, Zahraa A. Ali, Fatemeh Nouruzi, Abbas Abdollahi, Zahra Montaseri, Mojtaba Memariani, Elham Zarenezhad …
Read more Evaluating prognostic performance for acute delta changes of high-sensitivity cardiac troponin T in emergency department patientson February 25, 2026 at 3:40 pm February 25, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Fang Wu, Tanzy Love, Xueya Cai, Andrew Mathias, Kent B. Lewandrowski, Li Liu
Establishment of trimester-specific reference intervals for hemostatic and hematologic indices and their associations with adverse pregnancy outcomeson February 25, 2026 at 11:32 am February 25, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Huimin Shi, Jiayi Chen, Junwei Liu, Qingxiu Li, Bin Sun, Danwei Zhang, Zhengqin Wu, Haiyan Gao, Wei Li, …
Read more Exploration of the source of AQP4 antibody: Based on paired serum and cerebrospinal fluid samples from 98 patientson February 25, 2026 at 11:32 am February 25, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Tao Wu, Haiqiang Jin, Hongjun Hao, Yiming Zheng, Jing Guo, Nan Zhang, Ran Liu, Zhaoxia Wang, Feng Gao …
Read more Cardiac Biomarker Kinetics in Patients after Coronary Artery Bypass Grafting with an Uncomplicated Course February 25, 2026 Clin Chem. 2026 Feb 24:hvag012. doi: 10.1093/clinchem/hvag012. Online ahead of print. ABSTRACT BACKGROUND: The definition of periprocedural myocardial infarction (PMI) after coronary artery bypass grafting (CABG) remains debated, particularly regarding …
Read more Study on the reference intervals of six androgen “backdoor pathway” steroids in healthy Chinese adultson February 24, 2026 at 10:26 am February 24, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Yongqi Liu, Susu Cai, Shixin Sun, Yuxia Han, Xujing Kong, Jianfeng Zhou, Baorong Chen, Zenghe Li
AIM2 inflammasome and pyroptosis biomarkers in oncologyon February 24, 2026 at 10:26 am February 24, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Rajiv Dahiya, Abedalrahman Shqaidef, Soumya V. Menon, Vaibhav Rathore, Sanjay Singh, Manjari Mittal, Lakshmi Thangavelu, Nardev Singh, Arti …
Read more Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets February 23, 2026 Clin Chem. 2026 Feb 23:hvaf192. doi: 10.1093/clinchem/hvaf192. Online ahead of print. ABSTRACT BACKGROUND: Quantum machine learning (QML) is an emerging field that may offer unique advantages over classical machine learning …
Read more All for One and One for All? The Role of RNA-Based Next-Generation Sequencing in the Molecular Profiling of Tumors February 23, 2026 Clin Chem. 2026 Feb 23:hvag009. doi: 10.1093/clinchem/hvag009. Online ahead of print. NO ABSTRACT PMID:41725611 | DOI:10.1093/clinchem/hvag009
TUG1 and miR-145 as potential biomarkers associating hypothyroidism to cardiovascular riskon February 22, 2026 at 6:27 pm February 22, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Tarek K. Motawi, Olfat G. Shaker, Haidy Saied, Noha H. Sayed
Genomic sequencing enhances metabolic newborn screening in Thailandon February 22, 2026 at 6:27 pm February 22, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Chulaluck Kuptanon, Pawinee Innark, Kannikar Punnapum, Supaporn Nammoonnoy, Rotjanapan Pankanjanato, Maliwan Numnuan, Orapan Sripichai, Sukanya Wattanapokayakit, Punna Kunhapan, Ekke Kunphol
Outlook on ACADSB variants shaping metabolomic patterns and clinical outcomes − experience from a Central European countryon February 21, 2026 at 5:42 pm February 21, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Andrej Bandura, Ján Chandoga, Jerguš Vengríni, Miriama Juhosová, Alžbeta Vavrová, Elena Gregová, Miroslava Lysinová, Zuzana Mydlová, Katarína Brennerová, Jana Šaligová, …
Read more Smoking-dependent circulating non-coding biomarkers in lung canceron February 21, 2026 at 1:31 pm February 21, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Abdullah Farasani
Pathophysiologic mechanisms and molecular targets in preeclampsiaon February 21, 2026 at 1:31 pm February 21, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Jinxuan Ren, Mei Yang, Qing Zhu, Menghui Wang, Nanfang Li
Calibrator uncertainty (i.e., the uncertainty of the value assigned to the calibrator) and uncertainty of calibration procedure should not be mixed upKarin Toskaon February 20, 2026 at 11:00 am February 21, 2026 Clin Chem Lab Med. 2026 Feb 23. doi: 10.1515/cclm-2026-0103. Online ahead of print. NO ABSTRACT PMID:41718591 | DOI:10.1515/cclm-2026-0103
Assessment of non-invasive fibrosis scoring systems in pediatric MASLD: A retrospective comparison across healthy, MASLD, and biopsy-staged groupson February 20, 2026 at 12:54 pm February 20, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Nazmin Bithi, Sidharth Panda, Michael D. Dowlin, Sridevi Devaraj
T-cell receptor beta constant 1 flow cytometry for diagnosing clonality in mature T-cell neoplasms: a systematic review and meta-analysis of diagnostic accuracyPablo Adrian Biaggionion February 19, 2026 at 11:00 am February 20, 2026 Clin Chem Lab Med. 2026 Feb 20. doi: 10.1515/cclm-2025-1376. Online ahead of print. ABSTRACT INTRODUCTION: Accurate assessment of T-cell clonality is key for diagnosing mature T-cell neoplasms. TRBC1-based flow cytometry …
Read more Simultaneous Prenatal cfDNA Screening of Aneuploidy, Recessive Single-Gene Conditions, and Fetomaternal Blood Compatibility February 19, 2026 Clin Chem. 2026 Feb 19:hvag005. doi: 10.1093/clinchem/hvag005. Online ahead of print. ABSTRACT BACKGROUND: The provision of prenatal genetic screening in 3 core clinical contexts-recessive conditions, aneuploidy, and serological incompatibility-involves multiple …
Read more Applying the OMOP common data model to laboratory data: challenges, opportunities, and implications – a use case in biological variation researchBlanca Beumer Prietoon February 19, 2026 at 11:00 am February 19, 2026 Clin Chem Lab Med. 2026 Feb 20. doi: 10.1515/cclm-2025-1668. Online ahead of print. NO ABSTRACT PMID:41711567 | DOI:10.1515/cclm-2025-1668
Indirect reference intervals for thyroid function tests: refineR, RefLim and effects of pathological test resultson February 19, 2026 at 12:22 pm February 19, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Finn Erik Aas, Alexander Bauer Westbye, Magnus A.R. Husøy, Oskar E. Kelp, Svetlana N. Zykova, Per M. Thorsby
The 22q11.2 deletion syndrome: Genetic mechanisms, clinical manifestations, and therapeutic strategieson February 19, 2026 at 12:22 pm February 19, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Shaozhe Yang, Yuan Zhuang, Shuwen Xin, Yanqi He, Xiuhong Fu
CYFRA 21-1 as a circulating biomarker in non-small cell lung canceron February 19, 2026 at 12:22 pm February 19, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Neelam Singla, Kavita Goyal, Pawan Goud, Vaishali Goel, Avijit Mazumder, K.P. Hemalatha, Vijayakumar Sachidananda, Gaurav Gupta, Sachin Kumar …
Read more Artificial intelligence and machine learning applications in dialysis: Current applications, challenges, and future directionson February 19, 2026 at 12:22 pm February 19, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Aanuoluwapo Clement David-Olawade, Muyiwa Ademola Ogunbona, Olabanke Florence Olawuyi, Babajide David Makanjuola, John Oluwatosin Alabi, David B. Olawade …
Read more Interference and failure: The challenge of high-concentration IgM monoclonal protein in capillary zone electrophoresison February 18, 2026 at 5:42 pm February 18, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Yanhua Zhao, Minjie Zhang, Wei Gan
Machine learning in precision oncology: a rough diamond waiting to shine?Sander De Bruyneon February 18, 2026 at 11:00 am February 18, 2026 Clin Chem Lab Med. 2026 Feb 6. doi: 10.1515/cclm-2025-1706. Online ahead of print. NO ABSTRACT PMID:41704195 | DOI:10.1515/cclm-2025-1706
An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of testosterone in human serum and plasmaElie Fuxon February 18, 2026 at 11:00 am February 18, 2026 Clin Chem Lab Med. 2026 Feb 6. doi: 10.1515/cclm-2024-1266. Online ahead of print. ABSTRACT OBJECTIVES: This study presents a candidate reference measurement procedure (RMP) for testosterone quantification in human serum …
Read more 47th Annual Conference of the Association for Clinical Biochemists in Ireland (ACBI)on February 18, 2026 at 11:00 am February 18, 2026 Clin Chem Lab Med. 2026 Feb 5. doi: 10.1515/cclm-2026-0148. Online ahead of print. NO ABSTRACT PMID:41704184 | DOI:10.1515/cclm-2026-0148
Stability of different biochemical parameters in pooled left-over sera stored for 14 days after pooling either at room temperature or at 2-10 °CMaja Zabelon February 18, 2026 at 11:00 am February 18, 2026 Clin Chem Lab Med. 2026 Feb 5. doi: 10.1515/cclm-2025-1693. Online ahead of print. ABSTRACT OBJECTIVES: This stability study aimed to evaluate the stability of 48 biochemical analytes in pooled serum …
Read more Circulating integrins as biomarkers for bone metastasis in prostate canceron February 18, 2026 at 11:16 am February 18, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Bandar Theyab Alenezi, Abdullah R. Alzahrani, Zia Ur Rehman, Shatha Alzahrani, Hayaa M. Alhuthali, Amani A. Alrehaili, Abdul …
Read more 99th percentile upper reference limits of the 5th and 6th generation Elecsys® cardiac troponin T high-sensitivity assays in a single cohort of healthy blood donorsMargot Eggeron February 17, 2026 at 11:00 am February 18, 2026 Clin Chem Lab Med. 2026 Feb 19. doi: 10.1515/cclm-2026-0207. Online ahead of print. NO ABSTRACT PMID:41702055 | DOI:10.1515/cclm-2026-0207
Quantum Machine Learning in Laboratory Medicine: A Leap into the Future? February 18, 2026 Clin Chem. 2026 Feb 18:hvag013. doi: 10.1093/clinchem/hvag013. Online ahead of print. NO ABSTRACT PMID:41702419 | DOI:10.1093/clinchem/hvag013
Advancements in Blood Group Genotyping Technology and Clinical Applications February 18, 2026 Clin Chem. 2026 Feb 18:hvag008. doi: 10.1093/clinchem/hvag008. Online ahead of print. ABSTRACT BACKGROUND: Blood group typing is essential in transfusion medicine, transplantation, and prenatal care. With the elucidation of the …
Read more Multi-omic biomarker detection in UV-induced melanomaon February 17, 2026 at 10:29 am February 17, 2026 Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Safar M. Alqahtani, Muhammad Afzal, Obaid Afzal, Alhumaidi Alabbas, Pradnya Phalak, Kavita Goyal
Electrochemical biosensors for Calreticulin in lung Canceron February 17, 2026 at 10:29 am February 17, 2026 Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Obaid Afzal, Ali Altharawi, Mubarak A. Alamri, Manal A. Alossaimi, Abdulmalik S.A. Altamimi, Pawan Goud, Prerna Uniyal, Rakhi …
Read more Best practice recommendations for laboratory analysis and reporting of cerebrospinal fluid oligoclonal banding and associated tests for multiple sclerosis (MS): a consensus report from the harmonized CSF analysis for MS investigation (hCAMI) subcommittee of the Canadian society of clinical chemists (CSCC)on February 17, 2026 at 10:29 am February 17, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Victoria Higgins, Michelle L. Parker, Basma Ahmed, Vipin Bhayana, Ronald A. Booth, Yu Chen, Christine Collier, Mark S. Freedman, Myriam …
Read more The ARRplus: a model for renin-dependent and sex-specific aldosterone cut-offs that improves screening for primary aldosteronismSybille Fuldon February 16, 2026 at 11:00 am February 16, 2026 Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2025-1670. Online ahead of print. ABSTRACT OBJECTIVES: Screening for primary aldosteronism (PA) using the aldosterone:renin ratio (ARR) has suboptimal diagnostic accuracy, particularly …
Read more Characterization of STRC Gene Conversions by Nanopore Sequencing February 16, 2026 Clin Chem. 2026 Feb 16:hvag004. doi: 10.1093/clinchem/hvag004. Online ahead of print. ABSTRACT BACKGROUND: Biallelic loss-of-function variants of STRC are a frequent cause of mild to moderate nonsyndromic hearing loss. The …
Read more Personalized reference intervals based on biological variation for serum bone turnover markers in healthy older adultsYe Qinon February 16, 2026 at 11:00 am February 16, 2026 Clin Chem Lab Med. 2026 Feb 12. doi: 10.1515/cclm-2025-1138. Online ahead of print. ABSTRACT OBJECTIVES: The clinical utility of serum bone turnover markers (BTMs) in managing osteoporosis in the elderly …
Read more Optimizing diagnostic thresholds of total vitamin B12 (B12) for identifying cobalamin deficiency in adults with macrocytic anemiaMichela Pellosoon February 16, 2026 at 11:00 am February 16, 2026 Clin Chem Lab Med. 2026 Feb 13. doi: 10.1515/cclm-2025-1722. Online ahead of print. ABSTRACT OBJECTIVES: Identifying individuals with vitamin B12 (B12) deficiency is challenging due to poor harmonization across total …
Read more Analytical performance of the Roche Elecsys TnT hs Gen 6 immunoassayMarco Tosion February 16, 2026 at 11:00 am February 16, 2026 Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2026-0115. Online ahead of print. ABSTRACT OBJECTIVES: The acute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide, with …
Read more Interpretative comments and direct involvement in clinical care are among the most powerful tools of value-based laboratory medicineTomáš Šálekon February 16, 2026 at 11:00 am February 16, 2026 Clin Chem Lab Med. 2026 Feb 12. doi: 10.1515/cclm-2026-0152. Online ahead of print. NO ABSTRACT PMID:41696972 | DOI:10.1515/cclm-2026-0152
On the cusp of global lipoprotein(a) standardizationChrista M Cobbaerton February 16, 2026 at 11:00 am February 16, 2026 Clin Chem Lab Med. 2026 Feb 16. doi: 10.1515/cclm-2026-0149. Online ahead of print. ABSTRACT Lipoprotein(a) (Lp(a)) has the reputation of being the most misunderstood metric in laboratory medicine. The unique …
Read more Biological variability of transthyretin in patients with transthyretin cardiac amyloidosis: implications for therapy monitoringGiuseppe Vergaroon February 16, 2026 at 11:00 am February 16, 2026 Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2025-1529. Online ahead of print. NO ABSTRACT PMID:41696968 | DOI:10.1515/cclm-2025-1529
Age- and sex-specific reference intervals for 11-oxygenated androgens from infancy throughout childhood and adulthoodRobert Zeidleron February 16, 2026 at 11:00 am February 16, 2026 Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2025-1440. Online ahead of print. ABSTRACT OBJECTIVES: The adrenal glands are the main source of 11-oxygenated androgens (11-OAs), including the potent 11-ketotestosterone …
Read more From ordering to interpretation: a comprehensive framework for laboratory test indicationsJasmin Weningeron February 16, 2026 at 11:00 am February 16, 2026 Clin Chem Lab Med. 2026 Feb 6. doi: 10.1515/cclm-2025-1531. Online ahead of print. ABSTRACT OBJECTIVES: Clinical intent for laboratory testing (“indication”) is rarely recorded in structured form, limiting contextual interpretation, …
Read more Inter-laboratory variability in vancomycin measurement in an external quality assessment scheme 2016–2025on February 15, 2026 at 2:23 pm February 15, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Anders Larsson, Jonathan Cedernaes, Mats B. Eriksson, Anders Helldén, Moa Skarin, Päivi Ranta, Mathias Karlsson, Anna-Karin Hamberg
Testing brigatinib in an oncological patient’s hair: Evaluation of the time of disappearance after discontinuation and interpretation of concentrations obtained in regrowing hair after total losson February 14, 2026 at 12:40 pm February 14, 2026 Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Nadia Arbouche, Céline Traenklé, Jean-Sébastien Raul, Pascal Kintz
Exploring synergistic therapeutic potential of Erlotinib and artemisinin in non-small cell lung Cancer (NSCLC) using pharmacological networking and mathematical modelingon February 13, 2026 at 11:09 am February 13, 2026 Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Faiqa Suleman, Tasadduq Khan, Salah A. Alshehade, Muhammad Ali, Hafiz Muhammad Irfan, Amir Shahzad, Raghdaa Hamdan Al Zarzour, …
Read more Laboratory data mining: monitoring of the local applicability of prolactin reference intervalon February 13, 2026 at 11:09 am February 13, 2026 Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Sun Xiang, Zhu Jinwen, Wei Chen, Wang Qin
Aptasensors for NNK biomarkers in smoking-induced lung canceron February 13, 2026 at 11:09 am February 13, 2026 Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Bandar Theyab Alenezi, Talha Jawaid, Zia Ur Rehman, Abdullah R. Alzahrani, Abdul Hai, Waseem Fatima, Prawez Alam, Abida …
Read more Rethinking repeat testing: when analytical criteria tell different storiesÖzben Özden Işıklar Evin Kocatürk Zeynep Başoğlu Cansu Manav İbrahim Özkan Alataş Department of Medical Biochemistry, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkeyon December 24, 2025 at 11:44 am February 13, 2026 Volume 86, Issue 1, February 2026, Page 9-19.
Neuron-specific enolase measured in serum compared to plasma for neuroprognostication in out-of-hospital cardiac arrestYusuf A. Isse Christian Hassager Jacob E. Møller Ruth Frikke-Schmidt Benjamin Nyholm Frederik T. Søndergaard Johannes Grand Simon Mølstrøm Laust E. R. Obling Rasmus P. Beske Henrik Schmidt Jesper Kjaergaard Martin A. S. Meyer a Department of Cardiology, The Heart Center, Copenhagen University Hospital, Rigshospitalet, Denmarkb Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmarkc Department of Clinical Research, University of Southern Denmark, Odense, Denmarkd Department of Cardiology, Odense University Hospital, Odense, Denmarke Department of Clinical Biochemistry, Center of Diagnostic Investigation, Copenhagen University Hospital, Copenhagen, Denmarkf Department of Anesthesiology, Odense University Hospital, Odense, Denmarkg Department of Cardiothoracic Anesthesiology, The Heart Center, Copenhagen University Hospital, Rigshospitalet, Denmarkon January 10, 2026 at 1:50 am February 13, 2026 Volume 86, Issue 1, February 2026, Page 28-35.
Kidney damage biomarkers in predicting renal complications of allogeneic hematopoietic cell transplantation: a pilot prospective observational studyDorota Szcześ Marcin Żórawski Ewa Koc-Żórawska Monika Paskudzka Longin Niemczyk Agnieszka Tomaszewska Magdalena Tormanowska Ewa Karakulska-Prystupiuk Piotr Kacprzyk Kazimierz Hałaburda Olga Ciepiela Marlena Kwiatkowska-Stawiarczyk Anna Rodziewicz-Lurzyńska Jarosław Biliński Grzegorz Władysław Basak Jolanta Małyszko a Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Warsaw, Polandb Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, Warsaw, Polandc Department of Cardiology, Lipidology and Internal Medicine with Cardiac Intensive Care Unit, Medical University of Bialystok, Bialystok, Polandd The Academy of Applied Medical and Social Sciences, Elbląg, Polande Second Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Białystok, Polandf Central Laboratory, Central Teaching Hospital of University Clinical Center, Medical University of Warsaw, Warsaw, Polandg Institute of Hematology and Transfusion Medicine, Warsaw, Polandon February 4, 2026 at 12:04 pm February 13, 2026 Volume 86, Issue 1, February 2026, Page 53-65.
NMR-based metabolic measures of chronic stable angina and myocardial infarction in patients with diabetes mellituson February 13, 2026 at 11:09 am February 13, 2026 Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Ashish Gupta, Shiridhar Kashyap, Khushbhu Meena, Deepak Kumar, Amit Gaurav, Ankit Kumar Sahu, Subhash Yadav, Sudeep Kumar, Aditya …
Read more Managing demand for the direct antiglobulin test with a big data–derived predictive equationDavid Ceacero-Marín Isabel Puig-Pey Comas Javier Nieto-Moragas María J. Castro-Castro Anna Cortés Bosch De Bassea Mónica Vidal-Pla Lourdes Sánchez Navarro Clinical Laboratory, L’Hospitalet de Llobregat, Bellvitge University Hospital-IDIBELL, Barcelona, Spainon December 18, 2025 at 11:13 am February 13, 2026 Volume 86, Issue 1, February 2026, Page 20-27.
The reference intervals of PT, INR and APTT tests on the Cobas analyzer in Turkish pediatric populationBerrak Guven Ismail Benice Bilgehan Acikgoz Murat Can a Department of Biochemistry, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkeyb Department of Public Health, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkeyon January 8, 2026 at 7:28 am February 13, 2026 Volume 86, Issue 1, February 2026, Page 36-41.
Investigation of the relationship between trimethylamine N-oxide, CD36, and CD38 levels in individuals with a high triglyceride/HDL-cholesterol ratioGul Akar Fatma Sengul-Bag Fikret Akyurek Bahadir Ozturk a Department of Medical Services and Techniques, Simav Vocational School of Health Services, Kütahya Health Sciences University, Kütahya, Türkiyeb Department of Biochemistry, Faculty of Pharmacy, University of Adıyaman, Adıyaman, Türkiyec Department of Medical Biochemistry, Faculty of Medicine, University of Selçuk, Konya, Türkiyeon January 14, 2026 at 8:07 am February 13, 2026 Volume 86, Issue 1, February 2026, Page 42-52.
Assessment of oxidative stress parameters in neonatal indirect hyperbilirubinemia treated with phototherapyEmine Özçelik Salim Neşelioğlu Özcan Erel Ayşegül Zenciroğlu a Department of Pediatrics, Dr. Sami Ulus Training and Research Hospital, University of Health Sciences, Ankara, Turkeyb Department of Clinical Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, Ankara City Hospital, Ankara, Turkeyc Department of Neonatology, Dr. Sami Ulus Training and Research Hospital, University of Health Sciences, Ankara, Turkeyon January 30, 2026 at 12:37 pm February 13, 2026 Volume 86, Issue 1, February 2026, Page 66-71.
Sigma metric performances of Capillarys 3 Tera and Premier Hb9210 HbA1c analysers and comparison of conventional laboratory quality control practice with risk-based statistical quality control procedureZeynep Yildiz Dilara Turanlı Metin Alemdar Asuman Orçun Department of Biochemistry Laboratory, Kartal Dr. Lütfi Kırdar City Hospital, İstanbul, Turkeyon January 31, 2026 at 2:42 am February 13, 2026 Volume 86, Issue 1, February 2026, Page 72-78.
Monocyte distribution width reference intervals in healthy Chinese adults: a study revealing the impact of anticoagulant choiceQimei Wei Kun Luo Shanshan Dong Xin Li Wen Jiang Jun Yang Cuihua Tao a Department of Clinical Laboratory, Wuhan Asia Heart Hospital, Wuhan, People’s Republic of Chinab Department of Blood Transfusion, Wuhan Asia Heart Hospital, Wuhan, People’s Republic of Chinac Department of Blood Transfusion, Wuhan Asia General Hospital, Wuhan, People’s Republic of Chinaon February 4, 2026 at 12:06 pm February 13, 2026 Volume 86, Issue 1, February 2026, Page 79-85.
Biological variation estimates of direct and indirect LDL cholesterol by Friedewald and Martin-Hopkins formulas in healthy individualsFiliz Alkan Baylan Mehmet Özcan Şerif Ercan Ayşe Ciriz Esin Avcı Müjgan Ercan a Medical Biochemistry Department, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkeyb Department of Medical Biochemistry, Faculty of Medicine, Zonguldak Bülent Ecevit University, Zonguldak, Turkeyc Department of Medical Biochemistry, Lüleburgaz State Hospital, Kırklareli, Turkeyd Public Health Laboratory, Malatya, Turkeye Medical Biochemistry Department, Faculty of Medicine, Pamukkale University, Denizli, Turkeyf Department of Medical Biochemistry, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkeyon December 25, 2025 at 2:18 am February 13, 2026 Volume 86, Issue 1, February 2026, Page 1-8.
Evaluation of Large-Language Models for Structured Feature Extraction of Anatomic and Clinical Pathology Reports February 12, 2026 Clin Chem. 2026 Feb 12:hvag006. doi: 10.1093/clinchem/hvag006. Online ahead of print. ABSTRACT BACKGROUND: Feature extraction via manual chart review is often used for both patient care and research, but it …
Read more Recent advances in phosphatases as new biomarker in personalized medicineon February 11, 2026 at 3:09 pm February 11, 2026 Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Shreya Garge, Gayatri Gaikwad, Vasanti Suvarna
Application of thrombosis-related biomarkers in the diagnosis and thrombosis risk stratification of heparin-induced thrombocytopenia patientson February 10, 2026 at 3:14 pm February 10, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Huiping Wang, Pengju Lv, Chenxue Qu, Shoukui Hu
Serum zinc, copper, and the Zn/Cu ratio across the glycemic spectrum: evidence from an automated clinical chemistry platformon February 10, 2026 at 3:14 pm February 10, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Ufuk Sarıkaya, Şahabettin Selek, Alime Sarıkaya
Non-coding RNAs as prognostic biomarkers in autoimmune diseaseon February 9, 2026 at 1:57 pm February 9, 2026 Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Maryam Rahnama, Siamak Rezaeiani, Navid Ghasemzadeh, Milad Ahmadaghdami, Arezoo Mesri, Mortaza Taheri-Anganeh, Ebrahim Mazloomi
Non-coding RNAs as emerging biomarkers in melanomaon February 8, 2026 at 12:11 pm February 8, 2026 Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Qamar Abuhassan, Mutaz Jamal Al-khreisat, R. Roopashree, Maitreyee Panda, T. Sudhakar, Vipasha Sharma, Ashish Singh Chauhan, Guzal Klebleeva …
Read more Multi-omics biomarkers in psychiatric disorders diagnosis and stratificationon February 8, 2026 at 12:11 pm February 8, 2026 Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Seyyed Hossein Khatami, Sanam Anoosheh, Marzieh Khodaparast, Amir Maghsoudloonejad, Ehsan Dadgostar, Amir Asadi, Mahya Kaveh, Malihe Mehdinejad Haghighi …
Read more Synthetic data in the clinical laboratory: methods, applications, and future prospectson February 7, 2026 at 5:32 pm February 7, 2026 Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Tahir S. Pillay, Barbara S. van Deventer, Siphokazi Gwiliza, Evette L. Subramoney, Chantal van Niekerk
Development of machine learning-driven non-invasive diagnostic models for idiopathic membranous nephropathy in Chinese patientson February 6, 2026 at 11:43 am February 6, 2026 Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Qian Wang, Xiaolong Wang, Shibin Su, Weiguang Zhang, Quan Hong, Qiang Lyu, Shuwei Duan, Ying Zheng, Guichun Tang, …
Read more Evaluation of the Truenat® Chip-Based Real-Time PCR Platform for Infectious Disease Diagnosticson February 5, 2026 at 10:13 am February 5, 2026 Publication date: Available online 5 February 2026 Source: Practical Laboratory Medicine Author(s): João Renato Rebello Pinho, Gabriela Rampazzo Cruz, Priscila de Meira Oliveria, Fernanda de Mello Malta, Roberta Cardoso Petroni, …
Read more Combining conventional hemogram and reticulocyte metrics enhances iron deficiency detection in asymptomatic individualson February 5, 2026 at 10:13 am February 5, 2026 Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Mugdha Gautam, Prashant Sharma, Arnab Pal, Pulkit Rastogi, Praveen Sharma, Alka Rani Khadwal, Manu Jamwal, Minakshi Gupta, Reena …
Read more Comparison of manual with artificial intelligence-aided interpretation of ANA HEp-2 IIF assay patterns in a clinical diagnostics labon February 5, 2026 at 10:13 am February 5, 2026 Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Jonas Schmidt, Sarina Weiß, Frithjof Blessing, Josef Blessing, Peter Schierack, Stefan Rödiger, Rico Hiemann, Dirk Roggenbuck
A Mold-Like Organism in Urine Sediment February 3, 2026 Clin Chem. 2026 Feb 3;72(2):321-322. doi: 10.1093/clinchem/hvaf138. NO ABSTRACT PMID:41631817 | DOI:10.1093/clinchem/hvaf138
Triglyceride Turmoil: Unraveling a Complex Case February 3, 2026 Clin Chem. 2026 Feb 3;72(2):232-235. doi: 10.1093/clinchem/hvaf103. NO ABSTRACT PMID:41631816 | DOI:10.1093/clinchem/hvaf103
Commentary on Triglyceride Turmoil: Unraveling a Complex Case February 3, 2026 Clin Chem. 2026 Feb 3;72(2):236-237. doi: 10.1093/clinchem/hvaf128. NO ABSTRACT PMID:41631815 | DOI:10.1093/clinchem/hvaf128
