Journals – Clinical Chemistry INFO

Correction to: Challenges in Hb A1c Point-of-Care Testing: Only 5 of 19 Hb A1c Point-of-Care Devices Meet IFCC and NGSP Certification Criteria on Independent EvaluationJuly 2, 2025
Clin Chem. 2025 Jul 2:hvaf075. doi: 10.1093/clinchem/hvaf075. Online ahead of print. NO ABSTRACT PMID:40601566 | DOI:10.1093/clinchem/hvaf075
Cellular expression of PD-1, PD-L1 and CTLA-4 in patients with JAK2V617F mutated myeloproliferative disordersChristoph Winkleron July 2, 2025 at 10:00 amJuly 2, 2025
Clin Chem Lab Med. 2025 Jul 3. doi: 10.1515/cclm-2025-0306. Online ahead of print. ABSTRACT OBJECTIVES: The acquired, somatic JAK2V617F mutation is the most common molecular aberration in patients with myeloproliferative … Read more
Toxicological findings in Swedish cases of suspected drug-facilitated sexual assault (DFSA)Anna Möller Isabelle Högbeck Markus R. Meyer Daniela Wissenbach Olof Beck Anders Helander a Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Swedenb Department of Obstetrics and Gynecology, Södersjukhuset, Stockholm, Swedenc Department of Experimental and Clinical Toxicology and Pharmacology, Saarland University, Homburg, Germanyd Institute of Forensic Medicine, University Hospital Jena, Jena, Germanye Department Laboratory Medicine, Karolinska Institutet, Stockholm, Swedenf Departments of Clinical Pharmacology and Clinical Chemistry, Karolinska University Laboratory, Stockholm, Swedenon May 28, 2025 at 6:38 amJune 29, 2025
Volume 85, Issue 4, JULY 2025, Page 269-274.
Validation of cobas® pulse point-of-care testing device for blood glucose monitoringJosefine B. H. Adelhelm Charlotte S. Jørgensen Heidi B. Hansen Stine B. Østertoft Mads Nybo Louise H. Jørgensen Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmarkon May 30, 2025 at 11:13 amJune 29, 2025
Volume 85, Issue 4, JULY 2025, Page 275-280.
Renal elimination and eGFR prediction of proenkephalinJohann Sigurjonsson Ulf Nyman Henrik Bjursten David Grubb a Department of Cardiothoracic Anaesthesia and Intensive Care, Skåne University Hospital, Lund University, Lund, Swedenb Department of Translational Medicine, Division of Medical Radiology, Skåne University Hospital, Lund University, Lund, Swedenc Department of Cardiothoracic Surgery, Skåne University Hospital, Lund University, Lund, Swedenon June 10, 2025 at 5:20 amJune 29, 2025
Volume 85, Issue 4, JULY 2025, Page 281-286.
A novel modification approach for the one sample Kolmogorov-Smirnov test in large sample sizeUgurcan Sayili Mehmet Guven Gunver a Department of Public Health, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Türkiyeb Department of Biostatistics, Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Türkiyec Department of Biostatistics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiyeon June 5, 2025 at 4:35 amJune 29, 2025
Volume 85, Issue 4, JULY 2025, Page 287-298.
Comparison of total calprotectin levels with S100A8 and S100A9 subunit levels in critically ill patientsKristina Sejersen Aleksandra Mandic Havelka Miklos Lipcsey Anders Larsson a Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Swedenb Section of Clinical Chemistry, Unilabs Laboratory Medicine Stockholm, Solna, Swedenc Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Swedend Gentian Diagnostics AB, Stockholm, Swedene Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Swedenf Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, Uppsala, Swedenon June 2, 2025 at 5:22 amJune 29, 2025
Volume 85, Issue 4, JULY 2025, Page 299-304.
Comparison of serum antinuclear antibodies in Guillain–Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy: a retrospective case–control studyYu Tu Xuan Gong Jiewei Peng Peipei Zhu Wenyan Zhuo Xueying Yu a Department of Neurology, Zhuhai People’s Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Zhuhai, Chinab Department of Endocrinology, Zhuhai People’s Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Zhuhai, Chinac Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, Chinaon May 5, 2025 at 5:19 amJune 29, 2025
Volume 85, Issue 4, JULY 2025, Page 242-247.
Impact of preanalytical factors on the stability of acetylcholine receptor antibodies in serumDavid Lyse Overgaard Tina Parkner Josefine Jul Jarbæk Nielsen Henning Andersen Cindy Soendersoe Knudsen a Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmarkb Department of Clinical Medicine, Aarhus University, Aarhus, Denmarkc Department of Neurology, Aarhus University Hospital, Aarhus, Denmarkon May 8, 2025 at 6:31 amJune 29, 2025
Volume 85, Issue 4, JULY 2025, Page 308-312.
Increased serum anti-angiogenic factor levels in insulin-resistant obese children and adolescents with or without liver steatosis (NAFL)Samed Emre Darılmaz Melike Zeynep Tugrul Aksakal Gozde Ceylan Canan Kucukgergin Aylin Yetim Sahin Seldag Bekpinar a Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkeyb Department of Pediatrics, Division of Adolescent Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkeyon May 14, 2025 at 4:00 amJune 29, 2025
Volume 85, Issue 4, JULY 2025, Page 263-268.
Allele-Specific Digital PCR Enhances Precision and Sensitivity in the Detection and Quantification of Copy Number Alterations in Heterogeneous DNA SamplesJune 27, 2025
Clin Chem. 2025 Jun 19:hvaf054. doi: 10.1093/clinchem/hvaf054. Online ahead of print. ABSTRACT BACKGROUND: While genetic analyses are vital in cancer diagnostics, measuring copy number (CN) alterations remains challenging, especially in … Read more
Next-Generation Methods for More Precise Measurement of Cancer Genetic ChangesJune 27, 2025
Clin Chem. 2025 Jun 19:hvaf067. doi: 10.1093/clinchem/hvaf067. Online ahead of print. NO ABSTRACT PMID:40577536 | DOI:10.1093/clinchem/hvaf067
eGFR Inaccuracy in the Assessment of Living Kidney Transplant Donor EligibilityJune 27, 2025
Clin Chem. 2025 Jun 18:hvaf071. doi: 10.1093/clinchem/hvaf071. Online ahead of print. ABSTRACT BACKGROUND: Accurate glomerular filtration rate (GFR) estimation is crucial for evaluating living kidney donors, especially when measured GFR … Read more
Comprehensive evaluation of antiphospholipid antibody testing methodologies in APS diagnosis: performance comparisons across assay systems and clinical subtypesYun Wangon June 26, 2025 at 10:00 amJune 26, 2025
Clin Chem Lab Med. 2025 Jun 27. doi: 10.1515/cclm-2025-0499. Online ahead of print. ABSTRACT OBJECTIVES: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombosis and obstetric complications associated with … Read more
Oligoclonal banding analysis: assessing plasma use and time interval requirements for paired CSF and bloodLily Olayinkaon June 25, 2025 at 10:00 amJune 25, 2025
Clin Chem Lab Med. 2025 Jun 26. doi: 10.1515/cclm-2025-0649. Online ahead of print. NO ABSTRACT PMID:40560807 | DOI:10.1515/cclm-2025-0649
Exploring commutable materials for serum folate measurement: challenges in cross-method harmonizationXiaerbanu Nizhamudingon June 25, 2025 at 10:00 amJune 25, 2025
Clin Chem Lab Med. 2025 Jun 26. doi: 10.1515/cclm-2024-1403. Online ahead of print. ABSTRACT OBJECTIVES: Commutability is a critical attribute for reference materials (RMs) employed in standardization and calibration activities, … Read more
Isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedures for the quantification of total and free phenytoin in human serum and plasmaTobias Schierscheron June 21, 2025 at 10:00 amJune 21, 2025
Clin Chem Lab Med. 2025 Jun 23. doi: 10.1515/cclm-2024-0858. Online ahead of print. ABSTRACT OBJECTIVES: An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) was developed and … Read more
An isotope dilution-liquid chromatography-tandem mass spectrometry based candidate reference measurement procedure for the simultaneous quantification of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in human serum and plasmaKerstin Kandleron June 20, 2025 at 10:00 amJune 20, 2025
Clin Chem Lab Med. 2025 Jun 20. doi: 10.1515/cclm-2024-1138. Online ahead of print. ABSTRACT OBJECTIVES: An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification … Read more
Assessment of atypical cells in detecting bladder cancer in female patientsYan Zhaoon June 17, 2025 at 10:00 amJune 17, 2025
Clin Chem Lab Med. 2025 Jun 18. doi: 10.1515/cclm-2025-0268. Online ahead of print. ABSTRACT OBJECTIVES: Atypical or malignant urothelial cells may be identified with a research parameter of atypical cells … Read more
The spectrum of nuclear patterns with stained metaphase chromosome plate: morphology nuances, immunological associations, and clinical relevanceWilson de Melo Cruvinelon June 17, 2025 at 10:00 amJune 17, 2025
Clin Chem Lab Med. 2025 Jun 18. doi: 10.1515/cclm-2025-0286. Online ahead of print. ABSTRACT The indirect immunofluorescence assay (IFA) on HEp-2 cells is the prevailing method used to screen for … Read more
Quality indicators: an evolving target for laboratory medicineMario Plebanion June 16, 2025 at 10:00 amJune 16, 2025
Clin Chem Lab Med. 2025 Jun 17. doi: 10.1515/cclm-2025-0674. Online ahead of print. NO ABSTRACT PMID:40522869 | DOI:10.1515/cclm-2025-0674
A single dose of 20-mg of ostarine is detectable in hairJean-Claude Alvarezon June 16, 2025 at 10:00 amJune 16, 2025
Clin Chem Lab Med. 2025 Jun 17. doi: 10.1515/cclm-2025-0633. Online ahead of print. NO ABSTRACT PMID:40522865 | DOI:10.1515/cclm-2025-0633
Cell-Free DNA Comprises the Strand-Specific Characteristic Associated with Transcription and MethylationJune 16, 2025
Clin Chem. 2025 Jun 16:hvaf070. doi: 10.1093/clinchem/hvaf070. Online ahead of print. ABSTRACT BACKGROUND: Cell-free DNA (cfDNA) is a promising biomarker and carries information about physiological and pathological states. Nucleosome and … Read more
Health-related reference intervals for heavy metals in non-exposed young adultsChiara Di Restaon June 14, 2025 at 10:00 amJune 14, 2025
Clin Chem Lab Med. 2025 Jun 16. doi: 10.1515/cclm-2025-0076. Online ahead of print. ABSTRACT OBJECTIVES: Heavy Metals (HMs) concentrations vary with living environments, diet, and personal habits. This study aims … Read more
Optimal Value of Mutant KRAS Circulating Tumor DNA for Predicting Prognosis and Monitoring in Patients with Pancreatic Adenocarcinoma: A Prospective Multicenter Cohort StudyJune 13, 2025
Clin Chem. 2025 Jun 13:hvaf066. doi: 10.1093/clinchem/hvaf066. Online ahead of print. ABSTRACT BACKGROUND: The generalizability and applicability of circulating tumor DNA (ctDNA) KRAS mutations in patients with pancreatic adenocarcinoma (PAC) … Read more
Advances in Syphilis Diagnostics to Address the 21st-Century EpidemicJune 13, 2025
Clin Chem. 2025 Jun 13:hvaf072. doi: 10.1093/clinchem/hvaf072. Online ahead of print. ABSTRACT BACKGROUND: For 20 years, the United States has experienced a progressive rise in syphilis cases, increasing to >209 … Read more
Influence of Macrotroponin on the 99th Percentile Threshold in 2 High-Sensitivity Cardiac Troponin AssaysJune 10, 2025
Clin Chem. 2025 Jun 10:hvaf068. doi: 10.1093/clinchem/hvaf068. Online ahead of print. ABSTRACT BACKGROUND: Cardiac troponin (cTn) levels exceeding the 99th percentile upper reference limit and a rise/fall pattern are key … Read more
Australasian guideline for the performance of sweat chloride testing 3rd edition: to support cystic fibrosis screening, diagnosis and monitoringJohn Massieon June 6, 2025 at 10:00 amJune 6, 2025
Clin Chem Lab Med. 2025 Jun 9. doi: 10.1515/cclm-2025-0433. Online ahead of print. ABSTRACT The sweat test is used as a biological marker of cystic fibrosis transmembrane conductance regulator (CFTR) … Read more
Discordance between Cystatin C-Based and Creatinine-Based Estimated Glomerular Filtration Rate and Mortality in the General PopulationJune 4, 2025
Clin Chem. 2025 Jun 4:hvaf063. doi: 10.1093/clinchem/hvaf063. Online ahead of print. ABSTRACT BACKGROUND: The consequences for health outcomes of the discordance in cystatin C-based (eGFRcys) and creatinine-based (eGFRcr) estimated glomerular … Read more
FormulasJune 4, 2025
Clin Chem. 2022 Mar 4;68(3):483-484. doi: 10.1093/clinchem/hvab265. NO ABSTRACT PMID:40462360 | DOI:10.1093/clinchem/hvab265
Everyday PeopleJune 4, 2025
Clin Chem. 2022 Jun 1;68(6):864-865. doi: 10.1093/clinchem/hvac052. NO ABSTRACT PMID:40462370 | DOI:10.1093/clinchem/hvac052
Deconvoluting the Proteome with Confidence Using Mass Spectrometric ToolsJune 4, 2025
Clin Chem. 2022 Feb 1;68(2):374-375. doi: 10.1093/clinchem/hvab250. NO ABSTRACT PMID:40462369 | DOI:10.1093/clinchem/hvab250
0/2 h-Algorithm for Rapid Triage of Suspected Myocardial Infarction Using a Novel High-Sensitivity Cardiac Troponin I AssayJune 4, 2025
Clin Chem. 2022 Feb 1;68(2):303-312. doi: 10.1093/clinchem/hvab203. ABSTRACT BACKGROUND: We aimed to derive and validate a 0/2 h-algorithm using the new high-sensitivity cardiac troponin I (hs-cTnI)-VITROS assay (VITROS® Immunodiagnostic Products … Read more
Subclassification of Type 2 Diabetes Paves the Way for Personalized Outcome Prediction and Patient ManagementJune 4, 2025
Clin Chem. 2021 Mar 31;67(4):701. doi: 10.1093/clinchem/hvab003. NO ABSTRACT PMID:40462367 | DOI:10.1093/clinchem/hvab003
First Scientific Articles in Volume 1, Issue 1 of Clinical Laboratory JournalsJune 4, 2025
Clin Chem. 2021 Mar 31;67(4):702-704. doi: 10.1093/clinchem/hvaa182. NO ABSTRACT PMID:40462366 | DOI:10.1093/clinchem/hvaa182
From the Manhattan Project to COVID-19June 4, 2025
Clin Chem. 2022 May 18;68(5):739-741. doi: 10.1093/clinchem/hvac039. NO ABSTRACT PMID:40462365 | DOI:10.1093/clinchem/hvac039
A Seizure-Like Episode in a Healthy 12-Month OldJune 4, 2025
Clin Chem. 2022 Jul 27;68(8):1108-1110. doi: 10.1093/clinchem/hvac033. NO ABSTRACT PMID:40462364 | DOI:10.1093/clinchem/hvac033
Dateline 1975: Clinical Chemists Discuss the Need for StandardizationJune 4, 2025
Clin Chem. 2021 Apr 29;67(5):804-805. doi: 10.1093/clinchem/hvaa139. NO ABSTRACT PMID:40462363 | DOI:10.1093/clinchem/hvaa139
The Stradivarius of Proficiency TestingJune 4, 2025
Clin Chem. 2021 Aug 5;67(8):1164-1166. doi: 10.1093/clinchem/hvab073. NO ABSTRACT PMID:40462362 | DOI:10.1093/clinchem/hvab073
WheatiesJune 4, 2025
Clin Chem. 2021 Nov 1;67(11):1578. doi: 10.1093/clinchem/hvab179. NO ABSTRACT PMID:40462361 | DOI:10.1093/clinchem/hvab179
A comparison of current methods to measure antibodies in type 1 diabetesMaria Infantinoon June 3, 2025 at 10:00 amJune 4, 2025
Clin Chem Lab Med. 2025 Jun 4. doi: 10.1515/cclm-2025-0238. Online ahead of print. ABSTRACT OBJECTIVES: Type 1 diabetes (T1D) is a chronic autoimmune disease causing β-cell destruction, hyperglycemia, and lifelong … Read more
Validation of (self-collected) capillary blood using a topper collection system as alternative for venous sampling for 15 common clinical chemistry analytesRümeysa Geujaron June 3, 2025 at 10:00 amJune 3, 2025
Clin Chem Lab Med. 2025 Jun 2. doi: 10.1515/cclm-2025-0148. Online ahead of print. ABSTRACT OBJECTIVES: Home blood sampling for clinical purposes has gained much interest. This study validates the recently … Read more
No fault or negligence after an adverse analytical finding due to a contaminated supplement: mission impossible. Two examples involving trimetazidinePascal Kintzon June 3, 2025 at 10:00 amJune 3, 2025
Clin Chem Lab Med. 2025 May 30. doi: 10.1515/cclm-2025-0549. Online ahead of print. ABSTRACT Since several years, sports authorities, including national anti-doping organisations and the World Anti-Doping Agency (WADA) have … Read more
Immunochemical measurement of urinary free light chains and Bence Jones proteinuriaLaura Michettion June 3, 2025 at 10:00 amJune 3, 2025
Clin Chem Lab Med. 2025 May 30. doi: 10.1515/cclm-2025-0265. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate the characteristics of an immunochemical urinary free light chains (uFLC) test in screening … Read more
Arivale is dead ‒ Hooke is aliveMiyo K Chatanakaon May 30, 2025 at 10:00 amMay 31, 2025
Clin Chem Lab Med. 2025 May 30. doi: 10.1515/cclm-2025-0443. Online ahead of print. NO ABSTRACT PMID:40447988 | DOI:10.1515/cclm-2025-0443
Error in prostate-specific antigen levels after prostate cancer treatment with radical prostatectomyRemy J H Martenson May 30, 2025 at 10:00 amMay 30, 2025
Clin Chem Lab Med. 2025 May 29. doi: 10.1515/cclm-2025-0430. Online ahead of print. NO ABSTRACT PMID:40443083 | DOI:10.1515/cclm-2025-0430
Machine learning algorithms with body fluid parameters: an interpretable framework for malignant cell screening in cerebrospinal fluidXianfei Yeon May 29, 2025 at 10:00 amMay 30, 2025
Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2025-0302. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to develop and validate a machine learning (ML) model utilizing cerebrospinal fluid … Read more
Regulating the future of laboratory medicine: European regulatory landscape of AI-driven medical device software in laboratory medicineHikmet Can Çubukçuon May 29, 2025 at 10:00 amMay 30, 2025
Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2025-0482. Online ahead of print. ABSTRACT Artificial intelligence (AI) is rapidly transforming laboratory medicine, impacting medical devices and healthcare practices. Despite these … Read more
Serum biomarkers as early indicators of outcomes in spontaneous subarachnoid hemorrhageAnna Maria Auricchioon May 29, 2025 at 10:00 amMay 30, 2025
Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2025-0309. Online ahead of print. ABSTRACT OBJECTIVES: Spontaneous subarachnoid hemorrhage (sSAH) is a life-threatening neurological event with high morbidity and mortality. Predicting … Read more
Commutability evaluation of glycated albumin candidate EQA materialsRui Wuon May 29, 2025 at 10:00 amMay 30, 2025
Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2025-0507. Online ahead of print. ABSTRACT OBJECTIVES: In clinical practice, glycated albumin (GA), as a key biomarker reflecting the level of blood … Read more
Impact of analytical bias on machine learning models for sepsis prediction using laboratory dataMeryem Rumeysa Yesilon May 29, 2025 at 10:00 amMay 30, 2025
Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2025-0491. Online ahead of print. ABSTRACT OBJECTIVES: Machine learning (ML) models, using laboratory data, support early sepsis prediction. However, analytical bias in … Read more
Understanding the circulating forms of cardiac troponin: insights for clinical practicePanpan Lvon May 29, 2025 at 10:00 amMay 29, 2025
Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2024-1236. Online ahead of print. ABSTRACT Ischemic heart disease remains the leading cause of death globally, with acute coronary syndrome (ACS) being … Read more
Diagnosis of hemogobinopathies in the clinical laboratory: an occult Hofu hemoglobin on HPLCMaitane Echeverría Urrozon May 29, 2025 at 10:00 amMay 29, 2025
Adv Lab Med. 2025 Jan 23;6(2):213-216. doi: 10.1515/almed-2024-0175. eCollection 2025 Jun. ABSTRACT OBJECTIVES: Hemoglobinopathies are disorders affecting the structure, function and/or production of hemoglobin. These conditions are caused by mutations … Read more
Implementación del ADN libre circulante para la detección de aneuploidías fetalesIrene Madrigal Bajoon May 29, 2025 at 10:00 amMay 29, 2025
Adv Lab Med. 2025 Feb 28;6(2):144-153. doi: 10.1515/almed-2024-0110. eCollection 2025 Jun. NO ABSTRACT PMID:40438556 | PMC:PMC12107419 | DOI:10.1515/almed-2024-0110
Uso de inteligencia artificial en la predisposición genética a enfermedad crítica por COVID-19: evaluación comparativa de modelos de aprendizaje automáticoSalomon Martin Perezon May 29, 2025 at 10:00 amMay 29, 2025
Adv Lab Med. 2025 Apr 2;6(2):190-198. doi: 10.1515/almed-2024-0129. eCollection 2025 Jun. NO ABSTRACT PMID:40438555 | PMC:PMC12107414 | DOI:10.1515/almed-2024-0129
Biomarker repurposing: opportunities and challenges in the evolving field of laboratory medicineDamien Grusonon May 29, 2025 at 10:00 amMay 29, 2025
Adv Lab Med. 2024 Dec 31;6(2):221-223. doi: 10.1515/almed-2024-0158. eCollection 2025 Jun. NO ABSTRACT PMID:40438554 | PMC:PMC12107413 | DOI:10.1515/almed-2024-0158
Data science applied to the assessment of biological variation estimatesFernando Marques-Garciaon May 29, 2025 at 10:00 amMay 29, 2025
Adv Lab Med. 2025 Apr 1;6(2):154-159. doi: 10.1515/almed-2025-0042. eCollection 2025 Jun. ABSTRACT INTRODUCTION: Data science is an umbrella term encompassing a set of tools and processes that make it possible … Read more
Use of external quality assessment in extra-analytical phases in clinical laboratories in Spain: a survey by the Spanish Society of Laboratory Medicine (SEQCML)Andrea Caballero Garraldaon May 29, 2025 at 10:00 amMay 29, 2025
Adv Lab Med. 2025 Apr 21;6(2):199-205. doi: 10.1515/almed-2025-0067. eCollection 2025 Jun. ABSTRACT OBJECTIVES: Quality indicators (QIs) are a valuable tool for monitoring and improving extra-analytical phase performance in the clinical … Read more
Cómo manejar las muestras lipémicas para realización de contaje de células sanguíneas (CBC) en los analizadores hematológicos SysmexVanja Radišić Biljakon May 29, 2025 at 10:00 amMay 29, 2025
Adv Lab Med. 2025 Apr 1;6(2):173-180. doi: 10.1515/almed-2025-0037. eCollection 2025 Jun. NO ABSTRACT PMID:40438561 | PMC:PMC12107405 | DOI:10.1515/almed-2025-0037
Uso de la evaluación externa de la calidad en las fases extraanalíticas de los laboratorios clínicos españoles: una encuesta de la Sociedad Española de Medicina de Laboratorio (SEQCML)Andrea Caballero Garraldaon May 29, 2025 at 10:00 amMay 29, 2025
Adv Lab Med. 2025 Apr 3;6(2):206-212. doi: 10.1515/almed-2024-0160. eCollection 2025 Jun. NO ABSTRACT PMID:40438560 | PMC:PMC12107416 | DOI:10.1515/almed-2024-0160
How to handle lipemic CBC samples on Sysmex hematology analyzers?Vanja Radišić Biljakon May 29, 2025 at 10:00 amMay 29, 2025
Adv Lab Med. 2025 Mar 20;6(2):166-172. doi: 10.1515/almed-2024-0206. eCollection 2025 Jun. ABSTRACT OBJECTIVES: Lipemia poses a significant preanalytical problem for complete blood count (CBC) measurement due to limited and non-standardized … Read more
Diagnóstico de hemoglobinopatías en el laboratorio clínico: hallazgo de una hemoglobina hofu oculta en HPLCMaitane Echeverría Urrozon May 29, 2025 at 10:00 amMay 29, 2025
Adv Lab Med. 2025 Mar 31;6(2):217-220. doi: 10.1515/almed-2024-0081. eCollection 2025 Jun. NO ABSTRACT PMID:40438558 | PMC:PMC12107412 | DOI:10.1515/almed-2024-0081
Biomarkers to measure the need and the effectiveness of therapeutic supplementation: a critical issueSimona Ferraroon May 28, 2025 at 10:00 amMay 28, 2025
Clin Chem Lab Med. 2025 May 8. doi: 10.1515/cclm-2025-0518. Online ahead of print. NO ABSTRACT PMID:40435170 | DOI:10.1515/cclm-2025-0518
Effect of long-term frozen storage on stability of kappa free light chain indexMartin Schmidaueron May 28, 2025 at 10:00 amMay 28, 2025
Clin Chem Lab Med. 2025 May 8. doi: 10.1515/cclm-2025-0125. Online ahead of print. ABSTRACT OBJECTIVES: To investigate whether frozen storage duration influences κ-FLC index. METHODS: CSF and serum samples of … Read more
Robotic Process Automation in Laboratory MedicineMay 28, 2025
Clin Chem. 2025 May 28:hvaf060. doi: 10.1093/clinchem/hvaf060. Online ahead of print. NO ABSTRACT PMID:40432581 | DOI:10.1093/clinchem/hvaf060
An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 17β-estradiol in human serum and plasmaMyriam Otton May 28, 2025 at 10:00 amMay 28, 2025
Clin Chem Lab Med. 2025 May 26. doi: 10.1515/cclm-2024-1255. Online ahead of print. ABSTRACT OBJECTIVES: A new candidate isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based reference measurement procedure (RMP) has been … Read more
Diagnosis of Drug-Resistant Tuberculosis: Rapid Evaluation of Drug Susceptibility with Nanopore Targeted SequencingMay 27, 2025
Clin Chem. 2025 May 27:hvaf061. doi: 10.1093/clinchem/hvaf061. Online ahead of print. ABSTRACT BACKGROUND: Whole-genome sequencing (WGS) has limitations in clinical diagnostics due to host DNA interference and lower pathogen load … Read more
Macroprolactinaemia – some progress but still an ongoing problemMichael N Fahie-Wilsonon May 27, 2025 at 10:00 amMay 27, 2025
Clin Chem Lab Med. 2025 May 23. doi: 10.1515/cclm-2025-0586. Online ahead of print. NO ABSTRACT PMID:40421532 | DOI:10.1515/cclm-2025-0586
Candidate reference measurement procedure based on isotope dilution-two dimensional-liquid chromatography-tandem mass spectrometry for the quantification of androstenedione in human serum and plasmaMyriam Otton May 27, 2025 at 10:00 amMay 27, 2025
Clin Chem Lab Med. 2025 May 23. doi: 10.1515/cclm-2024-1135. Online ahead of print. ABSTRACT OBJECTIVES: Androstenedione (ASD) is a biomarker used in the diagnosis of hyperandrogenism and adrenal hyperplasia. Therefore, … Read more
Histamine metabolite to basal serum tryptase ratios in systemic mastocytosis and hereditary alpha tryptasemia using a validated LC-MS/MS approachAbdulrazzaq Alherakyon May 27, 2025 at 10:00 amMay 27, 2025
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0189. Online ahead of print. ABSTRACT OBJECTIVES: Histamine, mainly produced in mast cells (MC), plays a key role in allergy and inflammation. … Read more
Vitamin D metabolome in preterm infants: insights into postnatal metabolismTomas Matejekon May 26, 2025 at 10:00 amMay 26, 2025
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0311. Online ahead of print. ABSTRACT OBJECTIVES: To describe the structure of vitamin D metabolome and investigate the possible cause of high … Read more
Recommendations for the integration of standardized quality indicators for glucose point-of-care testingJulie L V Shawon May 26, 2025 at 10:00 amMay 26, 2025
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0448. Online ahead of print. ABSTRACT OBJECTIVES: Quality indicator (QI) monitoring is essential to quality assurance for point of care testing (POCT). … Read more
The Unholy Grail of cancer screening: or is it just about the Benjamins?Miyo K Chatanakaon May 26, 2025 at 10:00 amMay 26, 2025
Clin Chem Lab Med. 2025 May 8. doi: 10.1515/cclm-2025-0531. Online ahead of print. NO ABSTRACT PMID:40418679 | DOI:10.1515/cclm-2025-0531
The neglected issue of pyridoxal- 5′ phosphateCarmen Ricóson May 26, 2025 at 10:00 amMay 26, 2025
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0550. Online ahead of print. NO ABSTRACT PMID:40418841 | DOI:10.1515/cclm-2025-0550
High myoglobin plasma samples risk being reported as falsely low due to antigen excess – follow up after a 2-year period of using a mitigating procedureAnders O Olssonon May 26, 2025 at 10:00 amMay 26, 2025
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0409. Online ahead of print. ABSTRACT OBJECTIVES: Antigen excess (AE) or high dose hook-effect can seriously affect the reported concentration of an … Read more
Practical handling of hemolytic, icteric and lipemic samples for coagulation testing in European laboratories. A collaborative survey from the European Organisation for External Quality Assurance Providers in Laboratory Medicine (EQALM)Ann Helen Kristoffersenon May 26, 2025 at 10:00 amMay 26, 2025
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0319. Online ahead of print. ABSTRACT OBJECTIVES: Coagulation test results may be affected by hemolysis, icterus and/or lipemia (HIL). Detailed guidelines for … Read more
Diagnostic performance of morphological analysis and red blood cell parameter-based algorithms in the routine laboratory screening of heterozygous haemoglobinopathiesGermain Simonon May 26, 2025 at 10:00 amMay 26, 2025
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0210. Online ahead of print. ABSTRACT OBJECTIVES: The aim of this study was to carry out a cross-analysis of the morphological abnormalities … Read more
Growing importance of vocabularies in medical laboratoriesMarco Pradellaon May 26, 2025 at 10:00 amMay 26, 2025
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0545. Online ahead of print. NO ABSTRACT PMID:40418780 | DOI:10.1515/cclm-2025-0545
A cost-effective assessment for the combination of indirect immunofluorescence and solid-phase assay in ANA-screeningNicoletta Galloon May 26, 2025 at 10:00 amMay 26, 2025
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0170. Online ahead of print. ABSTRACT OBJECTIVES: Anti-nuclear antibodies (ANA) testing on indirect immunofluorescence (IIF) has been for a long time the … Read more
Analytical validation of hemolysis detection on GEM Premier 7000Laura Pighion May 26, 2025 at 10:00 amMay 26, 2025
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0525. Online ahead of print. NO ABSTRACT PMID:40418775 | DOI:10.1515/cclm-2025-0525
Reducing the Noise in Plasma Metagenomics to Further Define Clinical UtilityMay 26, 2025
Clin Chem. 2025 May 26:hvaf065. doi: 10.1093/clinchem/hvaf065. Online ahead of print. NO ABSTRACT PMID:40415580 | DOI:10.1093/clinchem/hvaf065
Full-Length Clonal Immunoglobulin Rearrangements in cfDNA: Improved Recovery and SequencingMay 26, 2025
Clin Chem. 2025 May 26:hvaf064. doi: 10.1093/clinchem/hvaf064. Online ahead of print. ABSTRACT BACKGROUND: Circulating tumor DNA present in cell-free DNA (cfDNA) serves as diagnostic, predictive, and prognostic markers in cancer … Read more
Challenges in Hb A1c Point-of-Care Testing: Only 6 of 19 Hb A1c Point-of-Care Devices Meet IFCC and NGSP Certification Criteria on Independent EvaluationMay 26, 2025
Clin Chem. 2025 May 26:hvaf059. doi: 10.1093/clinchem/hvaf059. Online ahead of print. ABSTRACT BACKGROUND: Access to Hb A1c testing in low- and middle-income countries (LMICs) can be limited, especially in rural … Read more
Plasma Neprilysin in Heart Failure: Response Dynamics and Clinical Associations Are Immunoassay DependentMay 21, 2025
Clin Chem. 2025 May 21:hvaf056. doi: 10.1093/clinchem/hvaf056. Online ahead of print. ABSTRACT BACKGROUND: Discordance among published findings on the plasma concentrations, response dynamics, and clinical associations of plasma neprilysin (NEP) … Read more
The frequency of JAK2 V617F mutation and its association with low EPO levels in polycythemia vera patientsRecai Aci Adem Keskin Özlem Sezer Taner Karakaya Samet Semiz Halit Kızılet a Söke Vocational School of Health Services, Aydın Adnan Menderes University, Aydın, Turkeyb Department of Medical Biochemistry, Faculty of Medicine, Aydın Adnan Menderes University, Aydın, Turkeyc Department of Internal Medicine, Department of Medical Genetics, Samsun University Faculty of Medicine, Samsun, Turkeyd Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkeyon May 8, 2025 at 9:37 amMay 9, 2025
.
Platelet indices at admission and their performance associated with predicting all-cause mortality in the ICU: a large cross-sectional cohort studyUsman Ali Department of Haematology, The Royal London Hospital, London, UKon May 4, 2025 at 5:59 amMay 6, 2025
.
Performance assessment of ChatGPT in classification of urine particlesLaura Pighi Davide Negrini Marco Tosi Giuseppe Lippi Section of Clinical Biochemistry, University of Verona, Verona, Italyon April 21, 2025 at 11:36 amMay 6, 2025
Volume 85, Issue 3, MAY 2025, Page 223-227.
Stability of 17 endocrine analytes in serum or plasma after four cycles of repeated freezing and thawingElisabet Tjernvoll Arne Åsberg Ingrid Alsos Lian Lena Løfblad Gunhild Garmo Hov Ketil Thorstensen Gustav Mikkelsen a Department of Clinical Chemistry, Trondheim University Hospital, Trondheim, Norwayb Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norwayon April 17, 2025 at 12:34 pmMay 6, 2025
Volume 85, Issue 3, MAY 2025, Page 190-195.
Evaluation of hemolysis as a source of interference in the determination of S-100B using the LIAISON® S100 assayJaime I. Sainz de Medrano Judit Julian Irene Martínez Anna Escalante Helena Castellà Victoria Ortiz Esther Fernández-Galán Javier Laguna a Department of Biochemistry and Molecular Genetics, CDB, Hospital Clínic, Barcelona, Spainb CORE Laboratory, CDB, Hospital Clínic, Barcelona, Spainc Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spainon April 11, 2025 at 6:36 amMay 6, 2025
Volume 85, Issue 3, MAY 2025, Page 220-222.
Converting waste into value. Stability of leftover EDTA whole blood: serum vs. plasma for nine clinical chemistry analysesCindhya Sithiravel Tor A. Strand Ingunn Tjelde Fauskrud Ine Kathrine Granberg Hege K. Tjølsen Hermansen Ragnhild Røysland Kjersti S. Bakken a Multidisciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norwayb Department of Research, Innlandet Hospital Trust, Lillehammer, Norwayc Center for International Health, University of Bergen, Bergen, Norwayd Department of Microbiology, Innlandet Hospital Trust, Lillehammer, Norwaye Institute of Clinical Medicine, University of Oslo, Oslo, Norwayf Women’s Clinic, Innlandet Hospital Trust, Lillehammer, Norwayon April 20, 2025 at 6:22 amMay 6, 2025
Volume 85, Issue 3, MAY 2025, Page 214-219.
The effect of common blood sampling types on metabolic screeningCeylan Bal Esra Özyurt Gülsen Yılmaz a Department of Biochemistry, Ankara Yıldırım Beyazıt University, Ankara, Turkeyb Department of Biochemistry, Ankara City Hospital, Ankara, Turkeyon April 10, 2025 at 6:03 amMay 6, 2025
Volume 85, Issue 3, MAY 2025, Page 196-201.
Exploratory method comparison analysis with emphasis on graphical illustrationsBent Kristensen Marc Ø. Nielsen Arlinda Ljoki Bo Zerahn Lars T. Jensen Department of Nuclear Medicine, Herlev University Hospital, Herlev, Denmarkon April 23, 2025 at 10:08 amMay 6, 2025
Volume 85, Issue 3, MAY 2025, Page 202-213.
Evaluation of measurement uncertainty in direct and estimated serum osmolality according to ISO/TS 20914: implications for clinical diagnosticsMehmet Fatih Alpdemir Sezen Tutar Medine Alpdemir a Medical Biochemistry, Ministry of Health Ankara Bilkent City Hospital, Ankara, Turkeyb Medical Biochemistry, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkeyon April 4, 2025 at 4:29 amMay 6, 2025
Volume 85, Issue 3, MAY 2025, Page 184-189.
Cold activation in PT-INR samples – Myth or reality in the modern laboratory?Annika Petersson Karin Strandberg Magnus Magnusson Jenny Lerman Kim Ekblom a Department of Clinical Chemistry and Transfusion Medicine, Växjö Central Hospital, Växjö, Swedenb Department of Translational Medicine, Lund University, Lund, Swedenc Department of Clinical Chemistry and Pharmacology, Division of Laboratory Medicine, Coagulation Laboratory, University and Regional Laboratories Region Skåne, Malmö, Swedend Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Swedene Department of Research and Development, Region Kronoberg, Växjö, Swedenon April 4, 2025 at 12:51 pmMay 6, 2025
Volume 85, Issue 3, MAY 2025, Page 175-179.
The effects of storage conditions on the stability of salivary melatonin in synthetic fiber swabs for home samplingJennifer Anton Charlotte S. Larsen Majken Gudmundsson Lasse K. Bak a Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Denmarkb Translational Research Center (TRACE), Copenhagen University Hospital, Rigshospitalet, Denmarkc Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmarkon April 10, 2025 at 2:38 amMay 6, 2025
Volume 85, Issue 3, MAY 2025, Page 180-183.
Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA for Identification of Targetable and Resistance Alterations in Advanced Solid TumorsMay 5, 2025
Clin Chem. 2025 May 5:hvaf045. doi: 10.1093/clinchem/hvaf045. Online ahead of print. ABSTRACT BACKGROUND: Existing circulating cell-free DNA (cfDNA) assays are primarily centralized, requiring specialized sample handling and transportation. Implementing a … Read more
Detecting cardiac injury: the next generation of high-sensitivity cardiac troponins improving diagnostic outcomesGiuseppe Lippion May 4, 2025 at 10:00 amMay 4, 2025
Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0418. Online ahead of print. ABSTRACT Cardiac injury, encompassing a spectrum of heart muscle damage, requires prompt and accurate diagnosis to improve … Read more
A value-based score for clinical laboratories: promoting the work of the new EFLM committeeMario Plebanion May 2, 2025 at 10:00 amMay 2, 2025
Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0490. Online ahead of print. ABSTRACT After the dissemination of a manifesto for the implementation of value-based laboratory medicine (VBLM) and a … Read more
Autoverified Chocolate-Colored Plasma SamplesMay 2, 2025
Clin Chem. 2025 May 2;71(5):612-613. doi: 10.1093/clinchem/hvaf026. NO ABSTRACT PMID:40314564 | DOI:10.1093/clinchem/hvaf026
Commentary on Secondary Amenorrhea and Clinical Hyperandrogenism in a 34-Year-Old Female: Polycystic Ovary Syndrome or Not?May 2, 2025
Clin Chem. 2025 May 2;71(5):547. doi: 10.1093/clinchem/hvaf006. NO ABSTRACT PMID:40314563 | DOI:10.1093/clinchem/hvaf006