Clin Chem Lab Med. 2025 Aug 29. doi: 10.1515/cclm-2025-0598. Online ahead of print. ABSTRACT OBJECTIVES: To develop a proactive risk assessment model for human papillomavirus (HPV) genotyping testing by integrating … Read more
Publication date: December 2025 Source: Clinical Biochemistry, Volume 140 Author(s): S.L. Boland, M.J.H. Doeleman, L.G.E. Hofstee, L. Soels, T.S.Q. Visser, S. de Roock, D. Hamann, J.M. van Montfrans, W.M. Tiel … Read more
Clin Chem. 2025 Aug 26:hvaf088. doi: 10.1093/clinchem/hvaf088. Online ahead of print. ABSTRACT BACKGROUND: Urinary tract infections (UTIs) are among the most common infections encountered in healthcare settings. Current diagnostic practices … Read more
Clin Chem. 2025 Aug 25:hvaf087. doi: 10.1093/clinchem/hvaf087. Online ahead of print. ABSTRACT BACKGROUND: Hexahydrocannabinol (HHC) and its analogs are recent additions to semi-synthetic cannabinoids in the recreational drug market. Here, … Read more
Clin Chem Lab Med. 2025 Jun 17. doi: 10.1515/cclm-2025-0427. Online ahead of print. ABSTRACT OBJECTIVES: Cardiac troponins (cTn) are used to detect and quantify acute cardiomyocyte injury. In patients presenting … Read more
Clin Chem Lab Med. 2025 Aug 26. doi: 10.1515/cclm-2025-0615. Online ahead of print. ABSTRACT OBJECTIVES: To determine whether the diagnostic accuracy of the liver fibrosis marker FIB-4 and the likelihood … Read more
Clin Chem Lab Med. 2025 Aug 26. doi: 10.1515/cclm-2025-0818. Online ahead of print. ABSTRACT OBJECTIVES: The increasing adoption of point-of-care testing (POCT) in primary healthcare highlights the need for robust … Read more
Clin Chem. 2025 Aug 25:hvaf094. doi: 10.1093/clinchem/hvaf094. Online ahead of print. ABSTRACT BACKGROUND: Protein biomarkers are routinely measured for disease diagnosis and prognosis in clinical laboratories. Since most assays focus … Read more
Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): R. Belardi, M. Emili, F.G. Viola, S. Velocci, M. Baldetti, M. Minieri, M. Pieri, E. Picchi, D. Morosetti, S. Bernardini, … Read more
Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): Simmi Patel, Octavia M. Peck Palmer, Chanda B. Lay, Kathleen Mulvey, Michael R. Shurin, Sarah E. Wheeler
Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Alan Carvalho Dias, Derliane de Oliveira, Fernando de Almeida Berlitz, José Antônio Tesser Poloni, Wilson Shcolnik, Claudia Maria … Read more
Clin Chem. 2025 Aug 22:hvaf092. doi: 10.1093/clinchem/hvaf092. Online ahead of print. ABSTRACT BACKGROUND: Population-wide reference intervals (RIpop) are commonly used in laboratory medicine but may not reflect an individual’s tightly … Read more
Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): Lisa V. Kalman, Yang Xia, Ya-Lin A. Huang, Kate Buchacz, Rex Astles, Jesse O’Shea
Clin Chem Lab Med. 2025 Aug 25. doi: 10.1515/cclm-2025-0743. Online ahead of print. ABSTRACT OBJECTIVES: Accurate quantification of aldosterone is critical for screening and diagnosing primary aldosteronism (PA). Current competitive … Read more
Clin Chem Lab Med. 2025 Aug 25. doi: 10.1515/cclm-2025-0870. Online ahead of print. ABSTRACT OBJECTIVES: Glial fibrillary acidic protein (GFAP) is a well-established biomarker of astrocytic activation associated with neurodegenerative … Read more
Clin Chem Lab Med. 2025 Aug 25. doi: 10.1515/cclm-2025-0137. Online ahead of print. ABSTRACT OBJECTIVES: Autoantibodies against structure elements of the pancreas are an essential part of laboratory diagnosis of … Read more
Clin Chem. 2025 Aug 21:hvaf093. doi: 10.1093/clinchem/hvaf093. Online ahead of print. ABSTRACT BACKGROUND: Next-generation sequencing for hepatitis B virus (HBV) and cytomegalovirus (CMV) antiviral drug resistance (AVDR) testing improves the … Read more
Clin Chem Lab Med. 2025 Aug 21. doi: 10.1515/cclm-2025-0656. Online ahead of print. ABSTRACT OBJECTIVES: ISO 15189:2022 recommends the use of quality indicators (QIs) to monitor laboratory performance and focuses … Read more
Clin Chem Lab Med. 2025 Aug 21. doi: 10.1515/cclm-2025-0654. Online ahead of print. ABSTRACT OBJECTIVES: Measurement uncertainty (MU) plays an important role in the interpretation of laboratory results, but data … Read more
Clin Chem Lab Med. 2025 Aug 20. doi: 10.1515/cclm-2025-0600. Online ahead of print. ABSTRACT OBJECTIVES: The T50 Calciprotein Crystallization test (T50 test) is a novel blood-based in vitro diagnostic assay … Read more
Clin Chem Lab Med. 2025 Aug 20. doi: 10.1515/cclm-2025-0705. Online ahead of print. ABSTRACT OBJECTIVES: Celiac disease (CD) is a systemic autoimmune disorder triggered by gluten in genetically predisposed individuals. … Read more
Clin Chem Lab Med. 2025 Aug 20. doi: 10.1515/cclm-2025-0939. Online ahead of print. ABSTRACT OBJECTIVES: The UK National Institute for Health and Care Excellence has recommended thresholds for total vitamin … Read more
Clin Chem Lab Med. 2025 Aug 20. doi: 10.1515/cclm-2025-1033. Online ahead of print. ABSTRACT The European Commission (EC) started targeted evaluations and public consultations regarding the EU IVDR 2017/746 to … Read more
Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Luisa Agnello, Giuseppe Vadalà, Anna Maria Ciaccio, Fabio Del Ben, Cristina Madaudo, Anna Masucci, Martina Tamburello, Roberta Vassallo, … Read more
Clin Chem Lab Med. 2025 Aug 19. doi: 10.1515/cclm-2025-0175. Online ahead of print. ABSTRACT OBJECTIVES: Spinal muscular atrophy (SMA) is a severe inherited neuromuscular disorder with a high carrier frequency … Read more
Clin Chem Lab Med. 2025 Aug 18. doi: 10.1515/cclm-2025-0754. Online ahead of print. ABSTRACT OBJECTIVES: α-Thalassaemia screening is crucial for identifying carriers at risk of having offspring with haemoglobin (Hb) … Read more
Clin Chem Lab Med. 2025 Aug 18. doi: 10.1515/cclm-2025-0763. Online ahead of print. ABSTRACT Laboratory data can be meaningful only when compared with reliable reference data; therefore, the estimation of … Read more
Clin Chem Lab Med. 2025 Aug 15. doi: 10.1515/cclm-2025-0802. Online ahead of print. ABSTRACT Laboratory investigations are important in the clinical management and the study of chronic kidney disease-mineral and … Read more
Clin Chem Lab Med. 2025 Aug 15. doi: 10.1515/cclm-2025-0143. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate the performance of the iStar high-sensitivity cardiac troponin I (hs-cTnI) assay, focusing on … Read more
Clin Chem Lab Med. 2025 Aug 15. doi: 10.1515/cclm-2025-0786. Online ahead of print. ABSTRACT Interpretation of laboratory test results is a comparative process that requires reference data. Such data are … Read more
Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): W. Greg Miller, Liesbet Deprez, Sverre Sandberg, Jesper V. Johansen, Neil Greenberg, Cas Weykamp, Thomas Keller, Jeffrey Budd, … Read more
Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Franja Dugar, Pedro Lopez-Ayala, Luca Koechlin, Paolo Bima, Jonas Glaeser, Carlos Spagnuolo, Luca Crisanti, Clara Wick, Karin Wildi, … Read more
Publication date: September 2025 Source: Practical Laboratory Medicine, Volume 46 Author(s): David Schär, Tobias U. Blatter, Harald Witte, Jivko Stoyanov, Martin Hersberger, Christos T. Nakas, Alexander B. Leichtle
Publication date: September 2025 Source: Practical Laboratory Medicine, Volume 46 Author(s): Tang Honghui, Wang Yifei, Bian Sihan, Mao Yanqing, Wang Lin
Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): Mary Kathryn Bohn, Dana Nyholt, Cynthia Balion, George Cembrowski, Christine Collier, Vincent De Guire, Victoria Higgins, Benjamin Jung, Olivia Landon, … Read more
Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): Janet R. Zhou, Andrea Kunst, Joshua E. Raizman, Miranda Brun, Yury Butorin, Fahed A. Elian, Lawrence de Koning, Samantha Logan, … Read more
Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): Emily Shang, Taylor Takasugi, Pedro Prellwitz, Cristina Figueroa Villalba, Rohit B. Sangal, Arjun K. Venkatesh, Lisa Maciejak, Erica Oberle, Joe … Read more
Clin Chem Lab Med. 2025 Aug 14. doi: 10.1515/cclm-2025-0658. Online ahead of print. ABSTRACT OBJECTIVES: Significant changes in clinical biochemical markers occur during the peri-menopausal period. Traditional population-based reference intervals … Read more
Clin Chem Lab Med. 2025 Aug 14. doi: 10.1515/cclm-2025-0647. Online ahead of print. ABSTRACT OBJECTIVES: Large language models (LLMs), such as OpenAI’s GPT-4o, have demonstrated considerable promise in transforming clinical … Read more
Clin Chem Lab Med. 2025 Aug 14. doi: 10.1515/cclm-2025-0552. Online ahead of print. ABSTRACT OBJECTIVES: Insulin assays are used to assess insulin resistance and to aid in the diagnosis of … Read more
Clin Chem. 2025 Aug 12:hvaf082. doi: 10.1093/clinchem/hvaf082. Online ahead of print. ABSTRACT BACKGROUND: There is increasing interest in the use of circulating cell-free RNA (cfRNA) in plasma as an analyte … Read more
Clin Chem. 2025 Aug 8:hvaf090. doi: 10.1093/clinchem/hvaf090. Online ahead of print. ABSTRACT BACKGROUND: Implementation of blood group genotyping has offered substantial benefits in transfusion medicine. However, the complex molecular basis … Read more
Clin Chem. 2025 Aug 7:hvaf085. doi: 10.1093/clinchem/hvaf085. Online ahead of print. ABSTRACT BACKGROUND: Hemophilia A and B are X-linked coagulation disorders characterized by low or dysfunctional Factor VIII (FVIII) or … Read more
