Beyond Affinity and Amplification: SPARK-seq and the Future of Clinical Laboratory Medicine March 17, 2026 Clin Chem. 2026 Mar 17:hvag024. doi: 10.1093/clinchem/hvag024. Online ahead of print. NO ABSTRACT PMID:41841764 | DOI:10.1093/clinchem/hvag024
Systemic Lupus Erythematosus and Epstein-Barr Virus: Recent Discoveries and Open Questions March 17, 2026 Clin Chem. 2026 Mar 17:hvag022. doi: 10.1093/clinchem/hvag022. Online ahead of print. NO ABSTRACT PMID:41841759 | DOI:10.1093/clinchem/hvag022
Three Assays, One Virus: Which Result Should We Trust? Variability in Quantitative Hepatitis B Surface Antigen Assays March 17, 2026 Clin Chem. 2026 Mar 17:hvag028. doi: 10.1093/clinchem/hvag028. Online ahead of print. NO ABSTRACT PMID:41841758 | DOI:10.1093/clinchem/hvag028
Labile hemoglobin A1c: an additional tool for identifying patients with poor glycemic controlWeiwei Hanon March 17, 2026 at 10:00 am March 17, 2026 Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0291. Online ahead of print. NO ABSTRACT PMID:41842835 | DOI:10.1515/cclm-2026-0291
Serum protein electrophoresis pattern associated with elevated polyclonal IgG4 concentrations: a monoclonal-mimicking profile with potentially significant clinical implicationsLaura Michettion March 17, 2026 at 10:00 am March 17, 2026 Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0183. Online ahead of print. ABSTRACT OBJECTIVES: To estimate the frequency and characterize the distinctive features of the serum electrophoretic pattern associated …
Read more Representation and performance of CE-marked and in-house in vitro diagnostic tests for routine laboratory parameters in external quality assessment programmesChristoph Buchtaon March 17, 2026 at 10:00 am March 17, 2026 Clin Chem Lab Med. 2026 Mar 17. doi: 10.1515/cclm-2026-0288. Online ahead of print. ABSTRACT OBJECTIVES: European legislation requires detailed performance evaluation of in vitro diagnostic medical devices (IVD-MD) by both …
Read more Current practices and harmonization challenges in Alzheimer’s disease biomarkers: an EFLM Committee: Harmonization SurveyLuisa Agnelloon March 17, 2026 at 10:00 am March 17, 2026 Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0168. Online ahead of print. ABSTRACT OBJECTIVES: Fluid biomarkers are central to the biological definition and diagnosis of Alzheimer’s disease (AD). Despite …
Read more Serum as an alternative to plasma for determining the ApoE4 phenotype using Pan-ApoE and ApoE4 chemiluminescent enzyme immunoassaysEric Kortmannon March 17, 2026 at 10:00 am March 17, 2026 Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0032. Online ahead of print. ABSTRACT OBJECTIVES: Since apolipoprotein E4 (ApoE4) is associated with therapy-related adverse effects of anti-amyloid-β monoclonal antibodies in …
Read more Beyond cholesterol: targeting inflammatory biomarkers in cardiovascular diseaseon March 17, 2026 at 6:39 pm March 17, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Qamar Abuhassan, Tamara Nazar Saeed, Ali Fawzi Al-Hussainy, Jalpa R. Patel, K.V. Jamuna, Vandana Tripathi, Samir Sahoo, Neeraj …
Read more Recommendations for establishing metrological traceability for in vitro diagnostic measurement procedures intended to be used for whole blood sampleson March 17, 2026 at 6:39 pm March 17, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Jesper V. Johansen, Cas Weykamp, Elizabeth Barczak, Kevin Horan, Sverre Sandberg, Liesbet Deprez, Vincent Delatour, Mauro Panteghini, Neil …
Read more Extracellular vesicles in cardiovascular disease: Biomarkers, therapeutic applications, and drug delivery strategieson March 17, 2026 at 6:39 pm March 17, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Qamar Abuhassan, Amirali Salajegheh, Faris Anad Muhammad, Ali Fawzi Al-Hussainy, Tushar B. Gajjar, Malathi Hanumanthayya, Sandeep Kumar Shukla, …
Read more Biochemical deciphering of an Atypical Methemoglobinemiaon March 17, 2026 at 2:20 am March 17, 2026 Publication date: Available online 15 March 2026 Source: Practical Laboratory Medicine Author(s): Antonin Lucbert, Hélène Caillon, Pierre-Olivier Bertho, Damien Masson, Manon Robert
Metabolomics biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysison March 17, 2026 at 2:20 am March 17, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Yuhong He, Hongxuan Liu, Weixia Li, Yuanyuan Yu, Huishu Lin, Shuhao Shi, Mengwei Lu, Hui Luo, Xiaoxue Li, …
Read more AI in the Prediction of Hepatic Fibrosis Progression Using Non-Coding RNAson March 17, 2026 at 2:20 am March 17, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Dibakar Roy, Md Sadique Hussain, Yumna Khan, Dhara N. Patel, Aseel Smerat, Neeraj Bainsal, Sumel Ashique, Arun Kumar, …
Read more Result harmonization in medical laboratories: accomplishments and challengesTony Badrickon March 15, 2026 at 10:00 am March 15, 2026 Clin Chem Lab Med. 2026 Mar 13. doi: 10.1515/cclm-2026-0323. Online ahead of print. ABSTRACT The Joint Committee for Traceability in Laboratory Medicine (JCTLM) supports worldwide equivalence and comparability of measurement …
Read more Point-of-care testing in the era of value-based laboratory medicineMario Plebanion March 14, 2026 at 10:00 am March 15, 2026 Clin Chem Lab Med. 2026 Mar 13. doi: 10.1515/cclm-2026-0309. Online ahead of print. ABSTRACT Point-of-care testing (POCT) represents a breakthrough technology in laboratory medicine that has expanded rapidly over the …
Read more Translating neurofilament light chain testing into clinical practice: a multidisciplinary implementation roadmapRoberto Furlanon March 14, 2026 at 10:00 am March 15, 2026 Clin Chem Lab Med. 2026 Mar 13. doi: 10.1515/cclm-2025-1743. Online ahead of print. ABSTRACT Neurofilament light chain (NfL) has been identified as a sensitive and broadly validated biomarker of neuroaxonal …
Read more Analytical performance of an automated LC-MS/MS analyzer for determination of vitamin D concentration in blood plasma and serumKatie Weaveron March 14, 2026 at 10:00 am March 15, 2026 Clin Chem Lab Med. 2026 Mar 13. doi: 10.1515/cclm-2026-0057. Online ahead of print. ABSTRACT OBJECTIVES: Measurement of the concentrations of vitamin D metabolites is clinically important because abnormal levels are …
Read more Population-specific reference intervals for 22 biochemical analytes: three indirect methods application in a multi-ethnic areaon March 14, 2026 at 11:46 pm March 14, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Shengxi Zhang, Hua Zhang, Yan Li, Ziqiao Lin, Yingying Sun, Zhenzhen Dai
A laboratory-driven clinical decision support system algorithm for personalized and automated cardiovascular risk stratification in primary care patients.on March 14, 2026 at 11:46 pm March 14, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Jordi Tortosa-Carreres, Mónica Piqueras, Carlos Cátedra, Ana Vañó-Bellver, Diana Domingo-Valero, Teresa Claramunt-Carbonell, Luís Martínez-Dolz, Begoña Laiz-Marro
From bench to bedside: translating the histone deacetylase inhibitors into prostate cancer therapieson March 14, 2026 at 11:46 pm March 14, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Sandra Moreira Rocha, Mafalda Baptista Brás, Bruno J. Pereira, Cláudio J. Maia
Underutilization of fentanyl testing masks substantial fentanyl exposure in routine urine drug screens in Indianaon March 14, 2026 at 11:46 pm March 14, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Halimat Olaniyan, Jennifer Beckman, Elizabeth Crosby, David Shepherd, Samir Dahal, Dina Greene, Michelle K. Zimmerman, Rejwi A. Dahal …
Read more Exploring clinical feasibility of zero-shot learning in a large language model for immunofixation electrophoresis image interpretationon March 14, 2026 at 11:46 pm March 14, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Berrin Oztas, Irfan Kosesoy
Targeted next-generation sequencing in diagnosing reproductive tract infections: a comparative studyon March 14, 2026 at 11:46 pm March 14, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Zhiyang Chen, Ziyang Li, Li Tan, Xiaorui Yuan, Yan Yu, Hu Ge, Senmiao Zhang, Xiaomeng Xia, Min Hu …
Read more Resolving a complex GPIHBP1 exons 3–4 deletion adjacent to low-complexity repeats using adaptive sampling long-read sequencing in familial chylomicronaemiaon March 14, 2026 at 11:46 pm March 14, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Nike Kwai Cheung Lau, Hoi Shan Leung, Tammy Tsz Yan Tong, Yeow Kuan Chong, Chor Kwan Ching
Corrigendum to “Genomic sequencing enhances metabolic newborn screening in Thailand” [Clin. Biochem. 142 (2026) 111107]on March 12, 2026 at 4:52 pm March 12, 2026 Publication date: Available online 12 March 2026 Source: Clinical Biochemistry Author(s): Chulaluck Kuptanon, Pawinee Innark, Kannikar Punnapum, Supaporn Nammoonnoy, Rotjanapan Pankanjanato, Maliwan Numnuan, Orapan Sripichai, Sukanya Wattanapokayakit, Punna Kunhapan, Ekke …
Read more Corrigendum to “Improving the environmental impact paradox of clinical medical laboratories” [Clin. Biochem. 141 (2026) 111063]on March 12, 2026 at 4:52 pm March 12, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Pernilla Sörme, Scott Weitze
CRISPR-Cas12a/Cas13a in cancer molecular diagnosison March 12, 2026 at 4:52 pm March 12, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Juncheng Lin, Yuyuan Wang, Biyun Zeng, Zhibing Chen, Xiaocong Lin, Tao Zeng
A complete blood count-based machine learning model for rapid differentiation of aplastic anemia, immune thrombocytopenia, and myelodysplastic syndromes in routine clinical practiceon March 12, 2026 at 4:52 pm March 12, 2026 Publication date: Available online 12 March 2026 Source: Practical Laboratory Medicine Author(s): Xiaohan Wang, Jian Huang, Jingwen Xi, Huan Liu, Yu Yuan
DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping March 12, 2026 Clin Chem. 2026 Mar 9:hvag007. doi: 10.1093/clinchem/hvag007. Online ahead of print. ABSTRACT BACKGROUND: DPYD testing can identify patients at risk for severe toxicity when a standard fluoropyrimidine antineoplastic dose is …
Read more CYFRA 21-1 in lymph node fine-needle aspiration washouts: added value in differentiated thyroid cancerAlfredo Campennion March 11, 2026 at 10:00 am March 12, 2026 Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2026-0251. Online ahead of print. ABSTRACT OBJECTIVES: Cervical lymph node metastases represent a key challenge in patients with differentiated thyroid carcinoma (DTC). …
Read more Towards the future of Endocrine Laboratory Medicine: defining the role of laboratory medicine specialists to strengthen the clinical-biological partnership – a joint opinion paper of EFLM-C:YS, IFCC TF-YS, and ESE-EYESCharles R Lefèvreon March 11, 2026 at 10:00 am March 12, 2026 Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2026-0101. Online ahead of print. ABSTRACT Clinical endocrinology relies critically on high-quality biochemical data for diagnosis, therapeutic decisions, and long-term patient monitoring. …
Read more An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 17-hydroxyprogesterone in human serum and plasmaMartina Bachmannon March 11, 2026 at 10:00 am March 12, 2026 Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2025-1169. Online ahead of print. ABSTRACT OBJECTIVES: Accurate measurement of 17α-hydroxyprogesterone (17-OHP) in human serum and plasma is required for steroid profiling, …
Read more Response to: Be aware of legally required metrology and higher-order reference measurement services run in calibration laboratoriesEmmanuel J Favaloroon March 11, 2026 at 10:00 am March 12, 2026 Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2026-0328. Online ahead of print. NO ABSTRACT PMID:41808360 | DOI:10.1515/cclm-2026-0328
Comparative Analysis of Diagnostic Kits for Detecting Ureaplasma spp. and M. hominis in Genital and Urinary Sampleson March 12, 2026 at 7:25 am March 12, 2026 Publication date: Available online 10 March 2026 Source: Practical Laboratory Medicine Author(s): Juliette Beaucarne, Ivana Buttice, Nada Riahi, Ethel Seyll, Mony Hing, Bram Vanmechelen, Delphine Martiny
Elevated IL-27 and altered anti-inflammatory cytokine levels in SLE patients with end-stage renal diseaseon March 12, 2026 at 7:25 am March 12, 2026 Publication date: June 2026 Source: Clinical Biochemistry, Volume 143 Author(s): Paria Bayati, Doaa Hussein Neamah, Yasser Bagheri, Somayeh Sadani, Nikoo Emtiazi, Mohsen Saeidi, Somayeh Ghorbani, Saeid Amirkhanlou
Performance evaluation of automated magnetic beads extraction method for the measurement of 23 plasma steroids using dual liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodon March 12, 2026 at 7:25 am March 12, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Han Chen, Gang Xu, Mei-juan Zhang, Fu-rong Ying, Hai-xia Huang, He-huan Liu, Jian-rong Yang
Clinical application progress and prospects of non-invasive preimplantation genetic testing (niPGT): A reviewon March 12, 2026 at 7:25 am March 12, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Shaozhe Yang, Rongxiang Li, Bo Xu, Yongyong Wu, Junfeng Li, Xiuhong Fu
Artificial intelligence algorithm optimization and application in patient-based real-time quality control (PBRTQC)on March 12, 2026 at 7:25 am March 12, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Bowen Su, Yanpeng Zhang, Xiaomin Shi
Liquid crystal-based biosensors for clinical diagnosticson March 12, 2026 at 7:25 am March 12, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Qamar Abuhassan, Jamal I. Al-Nabulsi, Subbulakshmi Ganesan, Subhashree Ray, V. Ramesh Kumar, Vipasha Sharma, Ashish Singh Chauhan, Zafar …
Read more Multi-omics biomarker detection in Diethylnitrosamine (DENA) induced hepatocellular carcinomaon March 12, 2026 at 7:25 am March 12, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Obaid Afzal, Pavan Goud, Kavita Goyal, Ali Altharawi, Mubarak A. Alamri, Manal A. Alossaimi, Abdulmalik S.A. Altamimi, Surya …
Read more Comparison of conventional formulas and machine learning models for estimating serum low-density lipoprotein cholesterolon March 12, 2026 at 7:25 am March 12, 2026 Publication date: April 2026 Source: Practical Laboratory Medicine, Volume 49 Author(s): Ruqiya Al Dhuhli, Nafila Al Riyami, Fatma Al Farsi, Ali Al Khamyasi, Huda Al Saadi, Said Al Alawi, Qutaiba …
Read more Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions March 9, 2026 Clin Chem. 2026 Mar 7:hvag010. doi: 10.1093/clinchem/hvag010. Online ahead of print. ABSTRACT BACKGROUND: Accurate descriptions of human genomic variants are crucial for gene-disease association, discovery, and clinical diagnosis. Although standardized …
Read more Increased Salicylate Concentration in a Patient Reporting No Aspirin Use March 9, 2026 Clin Chem. 2026 Mar 5;72(3):331-334. doi: 10.1093/clinchem/hvaf131. NO ABSTRACT PMID:41784385 | DOI:10.1093/clinchem/hvaf131
Commentary on Increased Salicylate Concentration in a Patient Reporting No Aspirin Use March 9, 2026 Clin Chem. 2026 Mar 5;72(3):334-335. doi: 10.1093/clinchem/hvaf151. NO ABSTRACT PMID:41784384 | DOI:10.1093/clinchem/hvaf151
Endogenous Lithium Levels and Alzheimer Disease March 9, 2026 Clin Chem. 2026 Mar 5;72(3):424-425. doi: 10.1093/clinchem/hvaf174. NO ABSTRACT PMID:41784383 | DOI:10.1093/clinchem/hvaf174
Commentary on Increased Salicylate Concentration in a Patient Reporting No Aspirin Use March 9, 2026 Clin Chem. 2026 Mar 5;72(3):335-336. doi: 10.1093/clinchem/hvaf179. NO ABSTRACT PMID:41784382 | DOI:10.1093/clinchem/hvaf179
Elevated Creatinine-Cause for Concern or False Alarm? March 9, 2026 Clin Chem. 2026 Mar 5;72(3):422-423. doi: 10.1093/clinchem/hvaf140. NO ABSTRACT PMID:41784381 | DOI:10.1093/clinchem/hvaf140
A Culture-Free Lipidomics-Based Screening Test for Uropathogens March 9, 2026 Clin Chem. 2026 Mar 5;72(3):381-389. doi: 10.1093/clinchem/hvaf164. ABSTRACT BACKGROUND: A rapid culture-free method is needed to improve diagnostic efficiency and guide timely antimicrobial therapy for urinary tract infections (UTIs). Previously, …
Read more An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of linezolid in human serum and plasmaMarie Kubicovaon March 9, 2026 at 10:00 am March 9, 2026 Clin Chem Lab Med. 2026 Mar 10. doi: 10.1515/cclm-2025-1366. Online ahead of print. ABSTRACT OBJECTIVES: The quantification of linezolid in serum and plasma matrices is crucial for therapeutic drug monitoring …
Read more Considerations and pragmatic strategies for implementation of point of care testing for high sensitivity cardiac troponin into the acute care settingPaul Collinsonon March 5, 2026 at 11:00 am March 9, 2026 Clin Chem Lab Med. 2026 Mar 5. doi: 10.1515/cclm-2026-0210. Online ahead of print. ABSTRACT A challenge in the implementation of rapid risk-stratification algorithms for patients with suspected acute coronary syndrome …
Read more Rare ANA patterns and their clinical correlates: a retrospective large-cohort studyRenren Ouyangon March 5, 2026 at 11:00 am March 9, 2026 Clin Chem Lab Med. 2026 Mar 5. doi: 10.1515/cclm-2025-1493. Online ahead of print. ABSTRACT OBJECTIVES: To determine the prevalence and clinical associations of rare HEp 2 indirect immunofluorescence ANA patterns …
Read more Inosine attenuates glycolysis in erythrocytes via glucose transporter inhibitionYukio Kume, Motohiro Ohkubo, Naru NaKatuka, Sayaka Aritake-Okada, Naoyuki Yoshikawa, Teruhiko Yoshida, Hideaki Isago, Makoto Kurano1Department of Clinical Laboratory, 719261The University of Tokyo Hospital, Tokyo, Japan2Graduate School of Health and Social Services, Saitama Prefectural University, Saitama, Japan3Department of Clinical Laboratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japanon March 2, 2026 at 11:35 am March 9, 2026 Annals of Clinical Biochemistry, Ahead of Print. BackgroundBlood glucose concentrations decrease after blood collection. We recently developed novel blood collection tubes containing inosine added to sodium fluoride (NaF; FI tubes), …
Read more Harnessing the gut–heart axis for cardiovascular drug innovation: microbiome, metabolites, and personalized treatment strategieson March 9, 2026 at 7:36 pm March 9, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Qhelen Mayline Chandra, Davini Clister, Princella Halim, Aminah Dalimunthe, Muhammad Ichwan, Dina Keumala Sari, Chindy Umaya, Nahida Aktary, …
Read more Heat-resistant cryoglobulin investigated through dynamic cryoaggregation assay and mass spectrometryon March 9, 2026 at 7:36 pm March 9, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Jing Jing Wang, Chiang Lu, Enny Soesilowati, Manxin Gao, Adrian Y.S. Lee
Performance evaluation of an automated mass spectrometry system for the measurement and isotyping of monoclonal immunoglobulinson March 9, 2026 at 7:36 pm March 9, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Jamie Ashby, Daniel McEntee, Dhananjay Sakrikar, Luke Ouverson, Rhiannon Stanton, Nia Marrott, Roshani R. Patel, Cristina Simion, Syreeta …
Read more Validation of parathyroid hormone measurement in fine-needle aspiration biopsy washings according to the IFCC LEAP checkliston March 9, 2026 at 7:36 pm March 9, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Ewa Kozłowska, Witold Chudziński, Aleksandra Kumorek, Olga Ciepiela
Isothermal nucleic acid amplification techniques: A comprehensive overview on their principle & applications as alternative to PCRon March 9, 2026 at 7:36 pm March 9, 2026 Publication date: April 2026 Source: Practical Laboratory Medicine, Volume 49 Author(s): Alazar Amare Amdiyee, Tesfaye Sisay Tessema
Clinical evaluation of CTS-1 specific coccidioidal immunodiffusion reagents for improved sensitivity and enhanced agreement with complement fixation testingon March 9, 2026 at 7:36 pm March 9, 2026 Publication date: Available online 9 March 2026 Source: Clinical Biochemistry Author(s): Erin Kaleta, Francisca J. Grill, Barbara Ronz, Thomas Grys, Douglas F. Lake
Normal serum cholinesterase does not exclude donepezil or galantamine toxicity: an interpretive pitfall of BuChE-based testingon March 9, 2026 at 7:36 pm March 9, 2026 Publication date: Available online 8 March 2026 Source: Clinical Biochemistry Author(s): Taku Mayahara, Tomohiro Katayama, Kazuyoshi Matsuura, Hiroyuki Arai, Eisaku Maruo
Genetic screening of EIF2B genes reveals mutation spectrum and predicted prevalence of vanishing white matter disease in Chinese populationon March 9, 2026 at 7:36 pm March 9, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Xiaoli Liu, Ruolan Guo, Zhan Qi, Yaodong Zhang, Xiaotun Ren, Wei Li, Xuyun Hu, Chanjuan Hao
Small extracellular vesicles as emerging biomarkers and therapeutic targets in neurodegenerative diseaseson March 9, 2026 at 7:36 pm March 9, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Askarova Zebo Zafarjonovna, Elmuratova Aysulu, Sanoeva Matlyuba, Hamroyev Rashid, Jurakulov Bakhrom Azamatovich, Ahmadjonov Ahmadjon, Amirullayeva Barno, Azimova Mayram …
Read more Harnessing exosomes for precision diagnostics and therapies in psychiatry disorderson March 9, 2026 at 7:36 pm March 9, 2026 Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Shaxlo Musinovna Xamidova, Achilova Donokhon, Kurbanov Obid, Rakhimova Gulnoz, Tolibov Dilshod, Tillashaykhova Khosiyat, Yazdankulova Gulnigor, Omarova Aynash, Abzairov …
Read more Laboratory quality indicators: persistent variability despite international harmonization effortsDiogo Jerônimoon March 3, 2026 at 11:00 am March 3, 2026 Clin Chem Lab Med. 2026 Mar 3. doi: 10.1515/cclm-2026-0076. Online ahead of print. NO ABSTRACT PMID:41774478 | DOI:10.1515/cclm-2026-0076
Discrepancies of results for post infusion levels of extended half-life factor VIII/IX concentrates – a cause of concern, awaiting for solutionArmando Tripodion March 3, 2026 at 11:00 am March 3, 2026 Clin Chem Lab Med. 2026 Mar 3. doi: 10.1515/cclm-2026-0042. Online ahead of print. ABSTRACT Hemophilia A and B are X-linked hemorrhagic disorders, characterized by low/dysfunctional factor (F)VIII or FIX, respectively. …
Read more Assessing precision, bias, and sigma metrics of 22 measurands using Ricos and EFLM specifications and implementation of internal quality control procedure in clinical chemistry laboratoryon March 3, 2026 at 4:25 pm March 3, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Khouloud Hkimi, Sonia Gara
Choosing Wisely Canada recommendations for point of care testing utilization in the acute care setting: Expert-based Delphi consensus from the Canadian Society of Clinical Chemistson March 3, 2026 at 4:25 pm March 3, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Sukhbir Kaur, Saranya Arnoldo, Jennifer Taher, Dana Bailey, Lori Beach, Daniel R. Beriault, Ihssan Bouhtiauy, Miranda Brun, Manal Elnenaei, Yun …
Read more Personalized reference intervals based on biological variation: a critical evaluation of strengths and limitationsAbdurrahman Coskunon March 3, 2026 at 11:00 am March 3, 2026 Clin Chem Lab Med. 2026 Mar 3. doi: 10.1515/cclm-2026-0263. Online ahead of print. NO ABSTRACT PMID:41772938 | DOI:10.1515/cclm-2026-0263
Methodological rigour and transparency are required for genotyping methods in genetic association studieson March 3, 2026 at 12:15 pm March 3, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Aditya K. Panda
Differences in laboratory reporting of thyroglobulin antibody positivity – a national survey across laboratories in the NetherlandsEliane F E Wenstedton March 2, 2026 at 11:00 am March 3, 2026 Clin Chem Lab Med. 2026 Mar 3. doi: 10.1515/cclm-2026-0056. Online ahead of print. NO ABSTRACT PMID:41771274 | DOI:10.1515/cclm-2026-0056
Diagnostic performance evaluation of the Siemens Healthineers Atellica HEMA 580 hematology analyzer for abnormal cell detection and optimization of immature myeloid cell cut-offsVincenzo De Iuliison March 2, 2026 at 11:00 am March 2, 2026 Clin Chem Lab Med. 2026 Mar 3. doi: 10.1515/cclm-2026-0083. Online ahead of print. ABSTRACT OBJECTIVES: We evaluated the diagnostic performance of the Atellica HEMA 580 hematology analyzer for complete blood …
Read more The conventional reference interval model: a historical framework?Werner Wosniokon March 2, 2026 at 11:00 am March 2, 2026 Clin Chem Lab Med. 2026 Mar 2. doi: 10.1515/cclm-2026-0169. Online ahead of print. NO ABSTRACT PMID:41766327 | DOI:10.1515/cclm-2026-0169
Urinary aldosterone and tetrahydroaldosterone by LC-MS/MS with enzymatic hydrolysis: validation and age-stratified reference intervalsIrene Wijbenga-van der Kooion March 1, 2026 at 11:00 am March 2, 2026 Clin Chem Lab Med. 2026 Mar 2. doi: 10.1515/cclm-2025-1679. Online ahead of print. ABSTRACT OBJECTIVES: Primary aldosteronism (PA) is a common cause of secondary hypertension. To address the specificity limits …
Read more Machine learning-based integration of antiphospholipid antibodies for predicting pregnancy outcomes in patients with recurrent spontaneous abortion: a multicenter prospective studyXinli Jiangon March 1, 2026 at 11:00 am March 2, 2026 Clin Chem Lab Med. 2026 Mar 2. doi: 10.1515/cclm-2026-0088. Online ahead of print. ABSTRACT OBJECTIVES: Antiphospholipid antibodies (aPLs) are closely associated with recurrent spontaneous abortion (RSA) and adverse pregnancy outcomes …
Read more Optimising lipoprotein(a) tests: we are almost thereMichel R Langloison March 1, 2026 at 11:00 am March 2, 2026 Clin Chem Lab Med. 2026 Mar 2. doi: 10.1515/cclm-2026-0269. Online ahead of print. NO ABSTRACT PMID:41764779 | DOI:10.1515/cclm-2026-0269
Explainable machine learning framework based on blood biomarkers and routine health information for assistive diagnosis and risk stratification of acute myocardial infarctionon February 28, 2026 at 2:53 pm February 28, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Xinglong Zhu, Ting Wang, Jidong Jiang, Minghui Zhang, Tao Liu, Xiaodong Zhang, Yiqing Wang
Multi-omics biomarkers in cadmium-related lung toxicity and carcinogenesison February 28, 2026 at 2:53 pm February 28, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Khalid Saad Alharbi
EGFR as a biomarker in colorectal Cancer: An electrochemical biosensing approachon February 28, 2026 at 2:53 pm February 28, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Mohammed Khaled Bin Break, Rahamat Unissa Syed, Weiam Hussein, Muhammad Nawaz, Randa Abdeen Hussein Abdalla, Nayla Ahmed Mohammed …
Read more Correction to: Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility? February 27, 2026 Clin Chem. 2026 Feb 27:hvag015. doi: 10.1093/clinchem/hvag015. Online ahead of print. NO ABSTRACT PMID:41758357 | DOI:10.1093/clinchem/hvag015
Umbilical cord mesenchymal stem cell exosomes in breast cancer. False hope or a real solution?on February 27, 2026 at 1:42 pm February 27, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Dana Jammoul, Toros Torossian, Mohamed Issa, May Saab, Chaza Harmouch, Rami Mhanna, Kawthar K. Abla
A Digital PCR Assay for Fetal Fraction Quantification Using Multiplex SNP and Y Chromosome Detection February 26, 2026 Clin Chem. 2026 Feb 26:hvag017. doi: 10.1093/clinchem/hvag017. Online ahead of print. ABSTRACT BACKGROUND: Fetal fraction (FF) quantification is critical for prenatal cell-free DNA screening. Current methods based on Y chromosome …
Read more Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine February 26, 2026 Clin Chem. 2026 Feb 26:hvag014. doi: 10.1093/clinchem/hvag014. Online ahead of print. ABSTRACT BACKGROUND: Clinical laboratory measurements provide essential results for prediction, screening, diagnosing, treating, monitoring, and prognosis of patients. To …
Read more Correction to: Discordance between Cystatin C-Based and Creatinine-Based Estimated Glomerular Filtration Rate and Mortality in the General Population February 26, 2026 Clin Chem. 2026 Feb 26:hvag003. doi: 10.1093/clinchem/hvag003. Online ahead of print. NO ABSTRACT PMID:41740614 | DOI:10.1093/clinchem/hvag003
Urinary free cortisol analyses: Enhancing their clinical performance in Cushing’s syndrome management by means of LC-MS/MSon February 26, 2026 at 12:46 pm February 26, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Ana Rubio, Santiago Tofé, Antonia Barceló
Detection of thyroid hormones T3 and T4 in urine and serum after levothyroxine administration: A pilot study relevant to doping analysison February 26, 2026 at 12:46 pm February 26, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): T. Colpaert, K. Van Uytfanghe, G. T’Sjoen, N. Van Haecke, W. Van Gansbeke, P. Van Renterghem, M. Olijhoek, …
Read more Glycated albumin: detection methods and standardizationon February 26, 2026 at 12:46 pm February 26, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Rui Wu, Tianjiao Zhang, Chuanbao Zhang
Gelsolin as a diagnostic biomarker in non-small cell lung Canceron February 26, 2026 at 12:46 pm February 26, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Imran Kazmi, Shakilur Rahman, Saleh Al Ghamdi, Mohammed Al-Zharani, Tarique Hussain Ashraf, Muhammad Afzal, Fahd A. Nasr, Faisal …
Read more Engineered Bacteria as living detectors of tumor DNA: A new diagnostic frontieron February 26, 2026 at 12:46 pm February 26, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Abdolmajid Ghasemian, Ali H. Al-Marzoqi, Zahraa A. Ali, Fatemeh Nouruzi, Abbas Abdollahi, Zahra Montaseri, Mojtaba Memariani, Elham Zarenezhad …
Read more Evaluating prognostic performance for acute delta changes of high-sensitivity cardiac troponin T in emergency department patientson February 25, 2026 at 3:40 pm February 25, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Fang Wu, Tanzy Love, Xueya Cai, Andrew Mathias, Kent B. Lewandrowski, Li Liu
Establishment of trimester-specific reference intervals for hemostatic and hematologic indices and their associations with adverse pregnancy outcomeson February 25, 2026 at 11:32 am February 25, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Huimin Shi, Jiayi Chen, Junwei Liu, Qingxiu Li, Bin Sun, Danwei Zhang, Zhengqin Wu, Haiyan Gao, Wei Li, …
Read more Exploration of the source of AQP4 antibody: Based on paired serum and cerebrospinal fluid samples from 98 patientson February 25, 2026 at 11:32 am February 25, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Tao Wu, Haiqiang Jin, Hongjun Hao, Yiming Zheng, Jing Guo, Nan Zhang, Ran Liu, Zhaoxia Wang, Feng Gao …
Read more Cardiac Biomarker Kinetics in Patients after Coronary Artery Bypass Grafting with an Uncomplicated Course February 25, 2026 Clin Chem. 2026 Feb 24:hvag012. doi: 10.1093/clinchem/hvag012. Online ahead of print. ABSTRACT BACKGROUND: The definition of periprocedural myocardial infarction (PMI) after coronary artery bypass grafting (CABG) remains debated, particularly regarding …
Read more Study on the reference intervals of six androgen “backdoor pathway” steroids in healthy Chinese adultson February 24, 2026 at 10:26 am February 24, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Yongqi Liu, Susu Cai, Shixin Sun, Yuxia Han, Xujing Kong, Jianfeng Zhou, Baorong Chen, Zenghe Li
AIM2 inflammasome and pyroptosis biomarkers in oncologyon February 24, 2026 at 10:26 am February 24, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Rajiv Dahiya, Abedalrahman Shqaidef, Soumya V. Menon, Vaibhav Rathore, Sanjay Singh, Manjari Mittal, Lakshmi Thangavelu, Nardev Singh, Arti …
Read more Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets February 23, 2026 Clin Chem. 2026 Feb 23:hvaf192. doi: 10.1093/clinchem/hvaf192. Online ahead of print. ABSTRACT BACKGROUND: Quantum machine learning (QML) is an emerging field that may offer unique advantages over classical machine learning …
Read more All for One and One for All? The Role of RNA-Based Next-Generation Sequencing in the Molecular Profiling of Tumors February 23, 2026 Clin Chem. 2026 Feb 23:hvag009. doi: 10.1093/clinchem/hvag009. Online ahead of print. NO ABSTRACT PMID:41725611 | DOI:10.1093/clinchem/hvag009
TUG1 and miR-145 as potential biomarkers associating hypothyroidism to cardiovascular riskon February 22, 2026 at 6:27 pm February 22, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Tarek K. Motawi, Olfat G. Shaker, Haidy Saied, Noha H. Sayed
Genomic sequencing enhances metabolic newborn screening in Thailandon February 22, 2026 at 6:27 pm February 22, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Chulaluck Kuptanon, Pawinee Innark, Kannikar Punnapum, Supaporn Nammoonnoy, Rotjanapan Pankanjanato, Maliwan Numnuan, Orapan Sripichai, Sukanya Wattanapokayakit, Punna Kunhapan, Ekke Kunphol
Outlook on ACADSB variants shaping metabolomic patterns and clinical outcomes − experience from a Central European countryon February 21, 2026 at 5:42 pm February 21, 2026 Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Andrej Bandura, Ján Chandoga, Jerguš Vengríni, Miriama Juhosová, Alžbeta Vavrová, Elena Gregová, Miroslava Lysinová, Zuzana Mydlová, Katarína Brennerová, Jana Šaligová, …
Read more Smoking-dependent circulating non-coding biomarkers in lung canceron February 21, 2026 at 1:31 pm February 21, 2026 Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Abdullah Farasani
