Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2025-0302. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to develop and validate a machine learning (ML) model utilizing cerebrospinal fluid … Read more
Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2025-0482. Online ahead of print. ABSTRACT Artificial intelligence (AI) is rapidly transforming laboratory medicine, impacting medical devices and healthcare practices. Despite these … Read more
Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2025-0309. Online ahead of print. ABSTRACT OBJECTIVES: Spontaneous subarachnoid hemorrhage (sSAH) is a life-threatening neurological event with high morbidity and mortality. Predicting … Read more
Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2025-0507. Online ahead of print. ABSTRACT OBJECTIVES: In clinical practice, glycated albumin (GA), as a key biomarker reflecting the level of blood … Read more
Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2025-0491. Online ahead of print. ABSTRACT OBJECTIVES: Machine learning (ML) models, using laboratory data, support early sepsis prediction. However, analytical bias in … Read more
Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2024-1236. Online ahead of print. ABSTRACT Ischemic heart disease remains the leading cause of death globally, with acute coronary syndrome (ACS) being … Read more
Adv Lab Med. 2025 Apr 1;6(2):154-159. doi: 10.1515/almed-2025-0042. eCollection 2025 Jun. ABSTRACT INTRODUCTION: Data science is an umbrella term encompassing a set of tools and processes that make it possible … Read more
Adv Lab Med. 2025 Apr 21;6(2):199-205. doi: 10.1515/almed-2025-0067. eCollection 2025 Jun. ABSTRACT OBJECTIVES: Quality indicators (QIs) are a valuable tool for monitoring and improving extra-analytical phase performance in the clinical … Read more
Adv Lab Med. 2025 Mar 20;6(2):166-172. doi: 10.1515/almed-2024-0206. eCollection 2025 Jun. ABSTRACT OBJECTIVES: Lipemia poses a significant preanalytical problem for complete blood count (CBC) measurement due to limited and non-standardized … Read more
Adv Lab Med. 2025 Jan 23;6(2):213-216. doi: 10.1515/almed-2024-0175. eCollection 2025 Jun. ABSTRACT OBJECTIVES: Hemoglobinopathies are disorders affecting the structure, function and/or production of hemoglobin. These conditions are caused by mutations … Read more
Clin Chem Lab Med. 2025 May 26. doi: 10.1515/cclm-2024-1255. Online ahead of print. ABSTRACT OBJECTIVES: A new candidate isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based reference measurement procedure (RMP) has been … Read more
Clin Chem. 2025 May 27:hvaf061. doi: 10.1093/clinchem/hvaf061. Online ahead of print. ABSTRACT BACKGROUND: Whole-genome sequencing (WGS) has limitations in clinical diagnostics due to host DNA interference and lower pathogen load … Read more
Clin Chem Lab Med. 2025 May 23. doi: 10.1515/cclm-2024-1135. Online ahead of print. ABSTRACT OBJECTIVES: Androstenedione (ASD) is a biomarker used in the diagnosis of hyperandrogenism and adrenal hyperplasia. Therefore, … Read more
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0189. Online ahead of print. ABSTRACT OBJECTIVES: Histamine, mainly produced in mast cells (MC), plays a key role in allergy and inflammation. … Read more
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0409. Online ahead of print. ABSTRACT OBJECTIVES: Antigen excess (AE) or high dose hook-effect can seriously affect the reported concentration of an … Read more
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0319. Online ahead of print. ABSTRACT OBJECTIVES: Coagulation test results may be affected by hemolysis, icterus and/or lipemia (HIL). Detailed guidelines for … Read more
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0210. Online ahead of print. ABSTRACT OBJECTIVES: The aim of this study was to carry out a cross-analysis of the morphological abnormalities … Read more
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0170. Online ahead of print. ABSTRACT OBJECTIVES: Anti-nuclear antibodies (ANA) testing on indirect immunofluorescence (IIF) has been for a long time the … Read more
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0311. Online ahead of print. ABSTRACT OBJECTIVES: To describe the structure of vitamin D metabolome and investigate the possible cause of high … Read more
Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0448. Online ahead of print. ABSTRACT OBJECTIVES: Quality indicator (QI) monitoring is essential to quality assurance for point of care testing (POCT). … Read more
Clin Chem. 2025 May 26:hvaf064. doi: 10.1093/clinchem/hvaf064. Online ahead of print. ABSTRACT BACKGROUND: Circulating tumor DNA present in cell-free DNA (cfDNA) serves as diagnostic, predictive, and prognostic markers in cancer … Read more
Clin Chem. 2025 May 26:hvaf059. doi: 10.1093/clinchem/hvaf059. Online ahead of print. ABSTRACT BACKGROUND: Access to Hb A1c testing in low- and middle-income countries (LMICs) can be limited, especially in rural … Read more
Clin Chem. 2025 May 21:hvaf056. doi: 10.1093/clinchem/hvaf056. Online ahead of print. ABSTRACT BACKGROUND: Discordance among published findings on the plasma concentrations, response dynamics, and clinical associations of plasma neprilysin (NEP) … Read more
Clin Chem. 2025 May 5:hvaf045. doi: 10.1093/clinchem/hvaf045. Online ahead of print. ABSTRACT BACKGROUND: Existing circulating cell-free DNA (cfDNA) assays are primarily centralized, requiring specialized sample handling and transportation. Implementing a … Read more
Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0418. Online ahead of print. ABSTRACT Cardiac injury, encompassing a spectrum of heart muscle damage, requires prompt and accurate diagnosis to improve … Read more
Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0490. Online ahead of print. ABSTRACT After the dissemination of a manifesto for the implementation of value-based laboratory medicine (VBLM) and a … Read more
Clin Chem. 2025 May 2:hvaf055. doi: 10.1093/clinchem/hvaf055. Online ahead of print. ABSTRACT BACKGROUND: There is a lack of robust biological variation (BV) data for porphyria-related biomarkers. Our study aimed to … Read more
Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0323. Online ahead of print. ABSTRACT Laboratory diagnostics play a crucial role in modern medicine and healthcare economics. The effective management of … Read more
Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0190. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratory errors pose a threat to patient safety and previous studies have demonstrated that … Read more
Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2024-1510. Online ahead of print. ABSTRACT OBJECTIVES: In the early stage of gastric cancer (GC), identifying cancer-specific biomarkers is a key step … Read more
Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2025-0352. Online ahead of print. ABSTRACT OBJECTIVES: In serum immunofixation electrophoresis, therapeutic monoclonal antibodies (tmAbs) can be misinterpreted as paraproteins. Strategies to … Read more
Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2025-0186. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) is critical for optimizing antipsychotic therapy, yet inter-laboratory comparability in China … Read more
Annals of Clinical Biochemistry, Ahead of Print. BackgroundMeasurement of cerebrospinal fluid (CSF) kappa free light chains (KFLCs) for the detection of intrathecal immunoglobulin synthesis has generated interest as an alternative … Read more
Annals of Clinical Biochemistry, Ahead of Print. BackgroundMaternal thyroid function significantly affects fetal development. However, thyroid hormone concentrations change dynamically throughout pregnancy rendering non-pregnancy reference ranges inaccurate. We aimed to … Read more
Clin Chem Lab Med. 2025 Apr 28. doi: 10.1515/cclm-2025-0486. Online ahead of print. ABSTRACT The IFCC Task Force on Global Lab Quality (TF-GLQ) has recently released a new guidance for … Read more
Clin Chem Lab Med. 2024 Dec 31;63(6):1139-1152. doi: 10.1515/cclm-2024-1350. Print 2025 May 26. ABSTRACT OBJECTIVES: Measurements of acid-base status are performed quickly after blood sampling avoiding errors. This necessitates rapid … Read more
Clin Chem Lab Med. 2025 Apr 25. doi: 10.1515/cclm-2025-0098. Online ahead of print. ABSTRACT OBJECTIVES: Potential coeliac disease (PCD) is defined by the presence of positive CD-specific autoantibodies with a … Read more
Clin Chem. 2025 Apr 24:hvaf044. doi: 10.1093/clinchem/hvaf044. Online ahead of print. ABSTRACT BACKGROUND: Metagenomic cell-free DNA (cfDNA) sequencing provides a new avenue for diagnosing infectious diseases. Owing to the low … Read more
Clin Chem. 2025 Apr 24:hvaf043. doi: 10.1093/clinchem/hvaf043. Online ahead of print. ABSTRACT BACKGROUND: In 2009, the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines established standards for … Read more
Clin Chem Lab Med. 2025 Apr 24. doi: 10.1515/cclm-2025-0329. Online ahead of print. ABSTRACT OBJECTIVES: To explore the reasons behind the lack of commutability in protein solution reference materials (RMs) … Read more
Clin Chem Lab Med. 2025 Apr 24. doi: 10.1515/cclm-2025-0478. Online ahead of print. ABSTRACT The negative impact of preanalytical errors on the quality of laboratory testing is now universally recognized. … Read more
Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0128. Online ahead of print. ABSTRACT OBJECTIVES: The diagnostic accuracy of presepsin (P-SEP) in the newborn is still under evaluation. METHODS: In … Read more
Clin Chem. 2025 Apr 18:hvaf039. doi: 10.1093/clinchem/hvaf039. Online ahead of print. ABSTRACT BACKGROUND: There have been conflicting messages about the influence of female sex hormones on women’s health, with historical … Read more
Clin Chem Lab Med. 2025 Apr 18. doi: 10.1515/cclm-2025-0203. Online ahead of print. ABSTRACT OBJECTIVES: Monoclonal gammopathies (MGs) are characterized by the presence of monoclonal immunoglobulins (M-proteins). Currently, recommendations for … Read more
