Correction to: Creatinine Measurement in Pediatrics: Is There Still a Role for the Compensated Jaffe Method? April 30, 2026 Clin Chem. 2026 Apr 29:hvag040. doi: 10.1093/clinchem/hvag040. Online ahead of print. NO ABSTRACT PMID:42054146 | DOI:10.1093/clinchem/hvag040
Reply to “Biological variation of serum cholinesterase activity in healthy subjects”: analytical validation of cholinesterase activity measurement in routine practice: experience from a French clinical laboratoryPierre Mercieron April 29, 2026 at 10:00 am April 30, 2026 Clin Chem Lab Med. 2026 Apr 29. doi: 10.1515/cclm-2026-0465. Online ahead of print. NO ABSTRACT PMID:42053521 | DOI:10.1515/cclm-2026-0465
No association between high plasma ionized calcium and minor neuropsychological symptoms in two general population cohortsCamilla J Kobyleckion April 29, 2026 at 10:00 am April 30, 2026 Clin Chem Lab Med. 2026 Apr 29. doi: 10.1515/cclm-2025-1356. Online ahead of print. ABSTRACT OBJECTIVES: Hypercalcemia has been associated with various non-specific minor neuropsychological symptoms but mainly in patient cohorts. …
Read more Advancing the implementation of standardised reporting units for haemostasis factor assays through collaborative effortsStephen MacDonaldon April 29, 2026 at 10:00 am April 30, 2026 Clin Chem Lab Med. 2026 Apr 29. doi: 10.1515/cclm-2026-0287. Online ahead of print. NO ABSTRACT PMID:42053189 | DOI:10.1515/cclm-2026-0287
Real-world performance of Lumipulse G plasma p-tau217: a six-month experience of a specialized clinical neurochemistry laboratoryBurak Arslanon April 29, 2026 at 10:00 am April 30, 2026 Clin Chem Lab Med. 2026 Apr 29. doi: 10.1515/cclm-2026-0370. Online ahead of print. ABSTRACT OBJECTIVES: Plasma p-tau217 is a leading blood-based biomarker for Alzheimer’s disease (AD), offering high diagnostic accuracy …
Read more Large language models and statistical calculations: a cautionary noteMatteo Vidalion April 29, 2026 at 10:00 am April 30, 2026 Clin Chem Lab Med. 2026 Apr 29. doi: 10.1515/cclm-2026-0409. Online ahead of print. NO ABSTRACT PMID:42054485 | DOI:10.1515/cclm-2026-0409
Clinical validation and implementation of mSTOP, a machine learning-based, longitudinal prediction model for the early identification of non-small cell lung cancer patients who not benefit from immune checkpoint inhibitor treatmentHuub H van Rossumon April 29, 2026 at 10:00 am April 30, 2026 Clin Chem Lab Med. 2026 Apr 29. doi: 10.1515/cclm-2025-1624. Online ahead of print. ABSTRACT OBJECTIVES: There has been a lot of interest in the field of laboratory medicine regarding the …
Read more The landscape of clinical pathology and laboratory medicine education in Brazil: challenges and disparities across 180 medical schoolsDébora Maria Tavares de Andradeon April 29, 2026 at 10:00 am April 30, 2026 Clin Chem Lab Med. 2026 Apr 29. doi: 10.1515/cclm-2026-0559. Online ahead of print. NO ABSTRACT PMID:42054102 | DOI:10.1515/cclm-2026-0559
High-throughput UHPLC–MS/MS method for 15 protein-bound uremic toxins in human serumon April 30, 2026 at 11:32 am April 30, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Qiong Wu, Zhipeng Wan, Jinhua Lan, Xiuxiu Zhang, Linlang Huang, Bo Ji, Longhao Chen, Yang Sha, Zhiguo Pan, …
Read more Trimethyllysine as a potential biomarker for heart failureon April 30, 2026 at 11:32 am April 30, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Yuyan Lei, Qing Fang, Qingqi Wu, Guiling Xiong, Junyi Jiang, Yu Wu, Lulu Chen, Dongsheng Ouyang, Zhenyu Li, …
Read more Poor Performance of LDL-Cholesterol Equations versus Beta Quantification in a Very Large Cohort of Patients with Dyslipidemia April 29, 2026 Clin Chem. 2026 Apr 28:hvag038. doi: 10.1093/clinchem/hvag038. Online ahead of print. ABSTRACT BACKGROUND: Accurate estimations of low-density lipoprotein cholesterol (LDL-C) is important to guide clinical decisions concerning lipid-lowering treatment. The …
Read more Saliva vs Plasma in Liquid Biopsy Sampling for Head and Neck Cancer: A Comparative Study April 29, 2026 Clin Chem. 2026 Apr 28:hvag035. doi: 10.1093/clinchem/hvag035. Online ahead of print. ABSTRACT BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) presents significant diagnostic and therapeutic challenges due to its rising …
Read more Accuracy evaluation of calibrator value assignment in 25-hydroxyvitamin D LC-MS/MS assays: a metrological traceability-based studyHewei Sunon April 28, 2026 at 10:00 am April 29, 2026 Clin Chem Lab Med. 2026 Apr 27. doi: 10.1515/cclm-2026-0450. Online ahead of print. NO ABSTRACT PMID:42048535 | DOI:10.1515/cclm-2026-0450
Identification of prohibited substances in contaminated dietary supplements associated with adverse analytical findings in athletesPascal Kintzon April 28, 2026 at 10:00 am April 29, 2026 Clin Chem Lab Med. 2026 Apr 27. doi: 10.1515/cclm-2026-0566. Online ahead of print. NO ABSTRACT PMID:42048171 | DOI:10.1515/cclm-2026-0566
Post-transplant ring sideroblasts are common in haploidentical peripheral blood stem cell transplantation but not linked to SF3B1 mutationsMarlene Hollensteinon April 26, 2026 at 10:00 am April 29, 2026 Clin Chem Lab Med. 2026 Apr 22. doi: 10.1515/cclm-2026-0080. Online ahead of print. ABSTRACT OBJECTIVES: To determine the prevalence of erythroid dysplasia and ring sideroblasts (RS) after peripheral blood stem …
Read more Albumin-adjusted (“corrected”) calcium should no longer be reported: a position statement from the Joint IOF Working Group and IFCC Committee on Bone Metabolism and EFLM Committee on CKDEtienne Cavalieron April 26, 2026 at 10:00 am April 29, 2026 Clin Chem Lab Med. 2026 Apr 20. doi: 10.1515/cclm-2026-0545. Online ahead of print. NO ABSTRACT PMID:42035248 | DOI:10.1515/cclm-2026-0545
Reporting of pre-analytical variables affecting the determination of brain-derived neurotrophic factor (BDNF) in patients with stroke: a scoping reviewElisa Bevilacquaon April 25, 2026 at 10:00 am April 29, 2026 Clin Chem Lab Med. 2026 Apr 21. doi: 10.1515/cclm-2026-0277. Online ahead of print. ABSTRACT INTRODUCTION: Brain-derived neurotrophic factor (BDNF) is a neurotrophin expressed in the central nervous system, where it …
Read more ANA fluorescence patterns and low C4 are associated with higher antiphospholipid antibody serological intensity in routine diagnostic testingNikolaos Androulakison April 25, 2026 at 10:00 am April 29, 2026 Clin Chem Lab Med. 2026 Apr 20. doi: 10.1515/cclm-2025-1709. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate whether antinuclear antibody (ANA) titre or HEp-2 fluorescence patterns are associated with antiphospholipid …
Read more When assays change but outcomes do not: analytical evaluation of the Roche Elecsys anti-TPO II assayMathilde Rieuon April 25, 2026 at 10:00 am April 29, 2026 Clin Chem Lab Med. 2026 Apr 20. doi: 10.1515/cclm-2026-0397. Online ahead of print. NO ABSTRACT PMID:42033199 | DOI:10.1515/cclm-2026-0397
Performance evaluation of five large language models for assisting in the interpretation of urinalysis reports for kidney diseases: a real-world studyTao Liuon April 25, 2026 at 10:00 am April 29, 2026 Clin Chem Lab Med. 2026 Apr 20. doi: 10.1515/cclm-2026-0435. Online ahead of print. ABSTRACT OBJECTIVES: Large language models (LLMs) show promise for interpreting laboratory reports, yet real-world validation remains limited. …
Read more Exosomes for myasthenia gravis: unraveling pathogenic insights and pioneering therapieson April 29, 2026 at 3:06 am April 29, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Zahra Oushyani Roudsari, Haniyeh Hashemi Motahar, Fatemeh Salahpour Anarjan, Fereshteh Rahdan, Gulandom Shodikulova, Istabraq H. Badr, Ahmad Movahedpour, …
Read more Right ventricular-centered metabolomics: A promising tool for phenotyping pulmonary arterial hypertensionon April 29, 2026 at 3:06 am April 29, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Aurora Vicenzi, Gianluca Pagnoni, Francesca Coppi
When urinalysis speaks first: Unexpected atypical urothelial cells revealing upper tract urothelial carcinomaon April 29, 2026 at 3:06 am April 29, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Oscar D. Pons-Belda, Cristina Prado-Majan, Paula López-Agulló, Ana Calbet-Tur, Emilia Moreno-Noguero
Defining age partitions for thyrotropin (TSH) reference intervals in infancy: a robust statistical approachon April 29, 2026 at 3:06 am April 29, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Udara Senarathne, Zhong Lu, James Doery, Natasha Heather, Campbell Kyle, Robert Heron, Joel Smith, Penelope Coates, Mohamed Saleem, …
Read more Evaluation and clinical application of an accurate isotope dilution liquid chromatography-tandem mass spectrometry method for serum glycocholic acidon April 29, 2026 at 3:06 am April 29, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Zhonggan Jin, Yuanzhu Ou, Ming Zong, Zhihan Ye, Zhizheng Li, Sujie Zhang, Hewei Sun, Xiaoyu Fan, Xialin Luo, …
Read more Potential value of serum IL-6 and IL-8 as biomarkers for screening and severity stratification of diabetic retinopathyon April 29, 2026 at 3:06 am April 29, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Yin-Li Wang, Hong Su, Li-Yan Hou, Chen-Xi Zhang, Yu-Fei Dong
Metal exposure in heart diseaseon April 29, 2026 at 3:06 am April 29, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Berthold Hocher
Novel Rapid Phenotypic Susceptibility Testing Techniques That Enhance Antimicrobial Stewardship and Clinical Decision-Making April 25, 2026 Clin Chem. 2026 Apr 24:hvag033. doi: 10.1093/clinchem/hvag033. Online ahead of print. ABSTRACT BACKGROUND: Antimicrobial resistance (AMR) is a critical global health challenge, underscoring the need for diagnostic innovations that enable …
Read more Labile Hemoglobin A1c (LHbA1c): From analytical interference to clinically valuable biomarkeron April 24, 2026 at 1:49 pm April 24, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Kai Wang, Weiwei Han
Troponin I interference in an 18-year-old patient with bradycardia: a case studyon April 24, 2026 at 12:19 am April 24, 2026 Publication date: Available online 22 April 2026 Source: Clinical Biochemistry Author(s): Huifeng Qian, Haiyong Jin, Shunchang Li
LC-MS/MS of PEth in Whole blood: implementation in routine clinical chemistryon April 23, 2026 at 6:28 am April 23, 2026 Publication date: Available online 21 April 2026 Source: Practical Laboratory Medicine Author(s): Jakob Albrethsen
High albumin sensitization drives uninterpretable basophil activation tests in cow’s milk allergyBenjamin Bonneton April 21, 2026 at 10:00 am April 22, 2026 Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0079. Online ahead of print. ABSTRACT OBJECTIVES: The basophil activation test (BAT) is increasingly used for diagnosing IgE-mediated food allergies, yet its …
Read more An important step forward for the implementation of 11-oxygenated androgensBrian Keevilon April 20, 2026 at 10:00 am April 22, 2026 Clin Chem Lab Med. 2026 Apr 16. doi: 10.1515/cclm-2026-0547. Online ahead of print. NO ABSTRACT PMID:42002923 | DOI:10.1515/cclm-2026-0547
S100B measurement in the maternal blood: a new promising tool for fetal well-being/distress monitoring?Laura Abellaon April 19, 2026 at 10:00 am April 22, 2026 Clin Chem Lab Med. 2026 Apr 15. doi: 10.1515/cclm-2025-1673. Online ahead of print. ABSTRACT Adverse event in the perinatal period constitutes today the wider bulk of investigation. Perinatal asphyxia (PA) …
Read more High-sensitivity cardiac troponin assays at the point of careKarl J Lackneron April 19, 2026 at 10:00 am April 22, 2026 Clin Chem Lab Med. 2026 Apr 16. doi: 10.1515/cclm-2026-0520. Online ahead of print. NO ABSTRACT PMID:42002543 | DOI:10.1515/cclm-2026-0520
Cuproptosis-related circulating non-coding RNAs as diagnostic and prognostic biomarkers in oncologyon April 22, 2026 at 1:57 pm April 22, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Obaid Afzal, Muhammad Afzal, Pavan Goud, Mano Priya Vijayan, Ali Altharawi, Mubarak A. Alamri, Manal A. Alossaimi, Abdulmalik …
Read more Circulating metabolic and inflammatory biomarkers in MINOCA: pathophysiologic mechanisms and clinical implicationson April 22, 2026 at 1:57 pm April 22, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Fuad A. Abdu, Hengji Hu, Peiyuan Lu
Letter to the editor regarding: “Heat-resistant cryoglobulin investigated through dynamic cryoaggregation assay and mass spectrometry”. Clinica Chimica acta 586(2026) 120935on April 22, 2026 at 1:57 pm April 22, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Lei Wang, Xingli Xu, Hongchen Zhou, Feng Zhang, Huahui Li
New insights into the TB-IGRA: Impact of endotoxin in blood collection tubes on test resultson April 22, 2026 at 1:57 pm April 22, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Ben Huang, Wenying Xia, Jue Wang, Chengcheng Liu, Yuqiao Xu, Weijuan Song
The association between ceramide levels and hepatic steatosis severity in metabolic dysfunction-associated fatty liver diseaseon April 22, 2026 at 1:57 pm April 22, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Rui Yang, Jinjiang Xu, Furong Zhao, Xiaoyu Sun, Ying Li, Yalian Zhang, Huijuan Peng, Ling Ding, Bin Guo …
Read more Convergence of multiplexed immunosensors, nanotechnology, and AI for early pancreatic cancer diagnosison April 19, 2026 at 9:04 pm April 19, 2026 Publication date: 15 July 2026 Source: Clinica Chimica Acta, Volume 589 Author(s): Qamar Abuhassan, Ahmed Faisal Mutee, Abdulkareem Shareef, Pareshkumar N. Pate, S. Renuka Jyothi, Gunjan Singh, Laxmidhar Maharana, Vimal …
Read more Transferability and Between Laboratory Imprecision of an LC-MS/MS-Based Reference Measurement Procedure for Apolipoproteins April 18, 2026 Clin Chem. 2026 Apr 18:hvag020. doi: 10.1093/clinchem/hvag020. Online ahead of print. ABSTRACT BACKGROUND: Apolipoprotein standardization in multiple calibration laboratories requires equivalent results to value assign matrix-based reference and external quality …
Read more Mitochondrial DNA copy number in leukocytes predicts long-term survival in prostate cancerTanja Langsenlehneron April 17, 2026 at 10:00 am April 18, 2026 Clin Chem Lab Med. 2026 Apr 16. doi: 10.1515/cclm-2025-1464. Online ahead of print. ABSTRACT OBJECTIVES: Low mitochondrial DNA copy number (mtCN) in leukocytes is a predictor of all-cause mortality, independent …
Read more Improving clinical interpretation of serum alpha-fetoprotein in children: using continuous and discrete reference intervalsDien Minh Tranon April 17, 2026 at 10:00 am April 18, 2026 Clin Chem Lab Med. 2026 Apr 15. doi: 10.1515/cclm-2026-0262. Online ahead of print. ABSTRACT OBJECTIVES: To establish discrete and continuous age-specific reference intervals for serum alpha-fetoprotein in children and to …
Read more Salivary testosterone reference intervals for adult women and menMirjam Kruijton April 17, 2026 at 10:00 am April 18, 2026 Clin Chem Lab Med. 2026 Apr 15. doi: 10.1515/cclm-2026-0144. Online ahead of print. ABSTRACT OBJECTIVES: Testosterone is increasingly being measured in saliva due to the ease of collection, which puts …
Read more Preliminary Comparative Evaluation of an Immunofluorescence Point-of-Care System and Central Laboratory Platforms for Measuring Cardiac Biomarkerson April 18, 2026 at 5:48 pm April 18, 2026 Publication date: Available online 18 April 2026 Source: Practical Laboratory Medicine Author(s): Michela Salvatici, Francesca Carreras, Monica Gaimarri, Chiara Corrado, Barbara Bianchi, Lorenzo Drago
Point of Concern for Troponin Testing with High-Sensitivity Assays in the Near Patient Setting April 16, 2026 Clin Chem. 2026 Apr 15:hvag034. doi: 10.1093/clinchem/hvag034. Online ahead of print. NO ABSTRACT PMID:41984057 | DOI:10.1093/clinchem/hvag034
Whose Role Is It, Anyway? Ensuring Correct Genomic Variant Nomenclature in Published Literature April 16, 2026 Clin Chem. 2026 Apr 13:hvag031. doi: 10.1093/clinchem/hvag031. Online ahead of print. NO ABSTRACT PMID:41973974 | DOI:10.1093/clinchem/hvag031
Performance, Safety, and Patient Experience of an Autonomous Robotic Phlebotomy Device: A Multicenter Trial April 16, 2026 Clin Chem. 2026 Apr 10:hvag029. doi: 10.1093/clinchem/hvag029. Online ahead of print. ABSTRACT BACKGROUND: Automated phlebotomy has the potential to improve patient outcomes and address phlebotomist workforce challenges. The Autonomous Blood …
Read more A seven-year review of the RCPAQAP dried bloodspot external quality assurance programNatasha Robbinson April 14, 2026 at 10:00 am April 16, 2026 Clin Chem Lab Med. 2026 Apr 15. doi: 10.1515/cclm-2026-0478. Online ahead of print. NO ABSTRACT PMID:41979518 | DOI:10.1515/cclm-2026-0478
Feasibility of improving sLe(a)/CA 19-9 harmonization by recalibration: a simulation study using three EQA programsHuub H van Rossumon April 14, 2026 at 10:00 am April 16, 2026 Clin Chem Lab Med. 2026 Apr 15. doi: 10.1515/cclm-2026-0155. Online ahead of print. ABSTRACT OBJECTIVES: The CA 19-9 tumor marker measures the sialylated Lewis a blood group antigen (sLe(a)) expressed …
Read more Linc00261: A potential liquid biopsy biomarker for colorectal cancer early detection and prognosison April 16, 2026 at 12:56 pm April 16, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Doaa Fathi, Mohamed Bakr Zaki, Ahmed I. Abulsoud, Tohada M. AL-Noshokaty, Amal Fawzy, Nehal I. Rizk
MassARRAY-based targeted detection of SLC22A5 mutations: A feasibility study for secondary screening of primary carnitine deficiency in newbornson April 16, 2026 at 12:56 pm April 16, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Lifei Gong, Jinqi Zhao, Lulu Li, Wei Liu, Zhihui Wan, Yue Tang, Shunan Wang, Bolun Cai, Yufei Zhao, …
Read more Short Tandem Repeat (STR) Typing of a Deceased Individual with an Extensive Blood Transfusion History: A Case Reporton April 16, 2026 at 12:56 pm April 16, 2026 Publication date: Available online 12 April 2026 Source: Practical Laboratory Medicine Author(s): Bea G. Gallardo, Minerva D. Sagum, Miriam Ruth M. Dalet, Nelvie Fatima Jane A. Soliven, Paul Ryan L. …
Read more Metrological traceability enters the boardroom of IVD-manufacturersChrista Cobbaerton April 11, 2026 at 10:00 am April 12, 2026 Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0535. Online ahead of print. NO ABSTRACT PMID:41965231 | DOI:10.1515/cclm-2026-0535
A simplified multitarget stool test for colorectal cancer and advanced precancerous lesion detectionShuizhi Xuon April 11, 2026 at 10:00 am April 12, 2026 Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0236. Online ahead of print. ABSTRACT OBJECTIVES: Multitarget stool tests are approved for colorectal cancer (CRC) screening. Here we developed a multitarget …
Read more Analytical and clinical performance of the Flash10 molecular point-of-care system for detection of influenza A and B virusesSheng Zengon April 11, 2026 at 10:00 am April 12, 2026 Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0093. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate the analytical performance and clinical workflow efficiency of the Flash10 molecular point-of-care testing …
Read more IgD-λ multiple myeloma with hidden light chain on immunofixation electrophoresis: a clinical caseXiao Huon April 11, 2026 at 10:00 am April 11, 2026 Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0250. Online ahead of print. NO ABSTRACT PMID:41964377 | DOI:10.1515/cclm-2026-0250
The prevalence and etiology of macro-growth hormone (GH)Hiroshi Ohnoon April 11, 2026 at 10:00 am April 11, 2026 Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0043. Online ahead of print. ABSTRACT OBJECTIVES: Several macro-hormones have been reported to date. Among them, macroprolactinemia is a common cause of …
Read more Eltrombopag-induced clinically negligible negative bias in creatinine measurements using enzymatic assaysShun Odaon April 9, 2026 at 10:00 am April 10, 2026 Clin Chem Lab Med. 2026 Apr 7. doi: 10.1515/cclm-2026-0216. Online ahead of print. NO ABSTRACT PMID:41956092 | DOI:10.1515/cclm-2026-0216
Pre-analytical stability of blood samples transported by drone versus ground: a pilot studyon April 10, 2026 at 5:59 pm April 10, 2026 Publication date: Available online 9 April 2026 Source: Practical Laboratory Medicine Author(s): Marie BRIONNE, Laure PEYRO-SAINT-PAUL, Jean-Jacques DUTHEIL, Denis VIVIEN, Hélène LEGROS, Simon LE HELLO, Rémy MORELLO
Pre-analytic error and possible misinterpretation for macrotroponinon April 10, 2026 at 5:59 pm April 10, 2026 Publication date: Available online 10 April 2026 Source: Clinical Biochemistry Author(s): Peter A. Kavsak, Oluwakemi Okwuegbuna, Naveen Naz
Development of a novel high-affinity anti-NGAL monoclonal antibody pair for sensitive detection of acute kidney injuryon April 10, 2026 at 5:59 pm April 10, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Nami Liao, Chen Duan, Junxi Liu, Siqin Peng, Shuo Zhang, Ting Wan, Xiyan Deng, Xinlan Zhang, Yilan Qiu, …
Read more Methylated Septin9 as an auxiliary biomarker for the diagnostic, recurrence monitoring and prognosis of colorectal canceron April 10, 2026 at 5:59 pm April 10, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Jiaxin Wang, Ying Li, Xuan Liu, Qian Gao, Lang Yi
Comparison of the analytical and clinical performance of three immunoassay platforms for plasma glial fibrillary acidic protein in Alzheimer’s diseaseYifei Wangon April 1, 2026 at 10:00 am April 7, 2026 Clin Chem Lab Med. 2026 Apr 2. doi: 10.1515/cclm-2025-1694. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to compare the analytical and clinical performance of plasma glial fibrillary acidic …
Read more An HIV Diagnostic Paradox in Late Pregnancy April 7, 2026 Clin Chem. 2026 Apr 2;72(4):433-436. doi: 10.1093/clinchem/hvaf134. NO ABSTRACT PMID:41925637 | DOI:10.1093/clinchem/hvaf134
Commentary on An HIV Diagnostic Paradox in Late Pregnancy April 7, 2026 Clin Chem. 2026 Apr 2;72(4):438. doi: 10.1093/clinchem/hvaf186. NO ABSTRACT PMID:41925636 | DOI:10.1093/clinchem/hvaf186
Commentary on An HIV Diagnostic Paradox in Late Pregnancy April 7, 2026 Clin Chem. 2026 Apr 2;72(4):437. doi: 10.1093/clinchem/hvaf172. NO ABSTRACT PMID:41925635 | DOI:10.1093/clinchem/hvaf172
Scientific Fraud at Scale: Challenges for Trust in Published Data April 7, 2026 Clin Chem. 2026 Apr 2;72(4):518-519. doi: 10.1093/clinchem/hvag002. NO ABSTRACT PMID:41925634 | DOI:10.1093/clinchem/hvag002
Next-generation proteomics in medical laboratories: metrologically sound quantitative protein tests vs. innovative and personalized proteome patternsYuri E M van der Burgton April 2, 2026 at 10:00 am April 7, 2026 Clin Chem Lab Med. 2026 Apr 3. doi: 10.1515/cclm-2026-0109. Online ahead of print. ABSTRACT In precision medicine protein phenotypes are foreseen that combined with pattern recognition tools exhibit great potential …
Read more Laboratory methods and specimen handling in clinical studies: a persistently neglected issueMario Plebanion April 2, 2026 at 10:00 am April 7, 2026 Clin Chem Lab Med. 2026 Apr 2. doi: 10.1515/cclm-2026-0447. Online ahead of print. NO ABSTRACT PMID:41923475 | DOI:10.1515/cclm-2026-0447
Investigation of alkaline phosphatase discrepancies on the Roche Cobas® pro: causes, solutions, and workflow optimizationon April 7, 2026 at 9:36 am April 7, 2026 Publication date: Available online 2 April 2026 Source: Clinical Biochemistry Author(s): I. Seiden-Long, K. Niemann, K. Moses, Y. Butorin, A.A. Venner, A.K.Y. Tsui, J.E. Raizman
Evaluation of a fluorescent-based point-of-care AMH assay: A bicentric assessment of analytical performance, method agreement, and usability.on April 7, 2026 at 9:36 am April 7, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Ali Khatib, Damien Gruson, Iman Azariouh, Soukayna Draoui, Wearm Zreikat, Gheyath K.Nasrallah
Emerging LncRNA HOTAIR and NME1 polymorphisms in ovarian cancer risk: A pilot case–control study in South Indian womenon April 7, 2026 at 9:36 am April 7, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Harshavardhani Canchi Sistla, Arun Seshachalam, Krishna Kumar Rathnam, Taruna Rajagopal, Srikanth Talluri, Nageswara Rao Dunna
Interference in protein S activity testing and free protein S: impact of lupus anticoagulant, elevated factor VIII, and anticoagulantson April 7, 2026 at 9:36 am April 7, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Jinghai Yan, Meilin Chen, Xiaojuan Kang, Yongqiang Yang, Longting Du, Shihong Zhang, Songzi Wang, Houmei Feng, Xiaohe Zheng …
Read more Performance evaluation and comparison of ChatGPT, Gemini, Grok, and DeepSeek in the interpretation of tumor marker reportson April 7, 2026 at 9:36 am April 7, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Xinglun Qi, Lina Fan, Yifan Yao, Shushi Shen, Zheng Yang, Junjie Zhu, Dagan Yang
Resolving method-dependent M-protein detection: a case of oligoclonality revealed through complementary immunotyping techniqueson April 7, 2026 at 9:36 am April 7, 2026 Publication date: June 2026 Source: Clinical Biochemistry, Volume 143 Author(s): Bing Wang, Yunchu Cui, Qihang Man, Yan Song
Inflammatory-nutritional biomarker scores and risk of malignant effusion in a pan-cancer cohort of 68,916 patients: Nonlinear associations and machine learning validationon April 1, 2026 at 8:04 pm April 1, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): R.N. Haoyu Liu, R.N. Yunhui Chen, R.N. Shouyan Wang
In-vitro verification of tolerance limits for biotin interference of routine biochemistry and immunology assaysKirsty Swallow, Graeme Wild, Ravishankar SargurImmunology Department and Protein Reference Unit, Northern General Hospital, Sheffield, UKon March 25, 2026 at 1:17 am April 1, 2026 Annals of Clinical Biochemistry, Ahead of Print. BackgroundBiotin is commonly used in many commercial assays. It is known that exogenous biotin can interfere with these tests, however, not all manufacturers …
Read more Lipemia-Induced Pseudohyponatremia: Analytical Bias Beyond Manufacturer Claimson April 1, 2026 at 8:04 pm April 1, 2026 Publication date: Available online 31 March 2026 Source: Practical Laboratory Medicine Author(s): Jeanne E. van Dongen, Volkher Scharnhorst, Nienke Geerts
Determination of age-specific reference intervals for ethanolamine plasmalogen species in red blood cells using liquid chromatography tandem mass spectrometryon April 1, 2026 at 12:47 am April 1, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Irene De Biase, Malgorzata Miller, Lauren M. Zuromski, Katherine J. Anderson, Stacey L. Cole, Preejith P. Vachali, Tatiana …
Read more Stability study of 17 clinical immunoassays analytes in serum and plasma samples within an automated storage and retrieval module: Assessment of add-on testing policieson March 31, 2026 at 6:16 am March 31, 2026 Publication date: Available online 28 March 2026 Source: Clinical Biochemistry Author(s): Bouriche Mohammed, Leven Cyril, Kerspern Hélène, Plee-gautier Emmanuelle, Capaldo Clément
High-throughput quantification of tacrolimus in whole blood by acoustic ejection mass spectrometry: analytical validation and comparative assessment against conventional LC-MS/MS for therapeutic drug monitoringon March 31, 2026 at 6:16 am March 31, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Xin-Yu Wu, Xiao-Kang Fu, Ao Li, Wei Zhang, Han-Peng Jiang, Na An, Quan-Fei Zhu, Shao-Ting Wang, Yu-Qi Feng …
Read more Thyroid hormone profile and biological variation in a population of athletes during an entire sport seasonon March 31, 2026 at 6:16 am March 31, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Isabel Moreno-Parro, Jorge Díaz-Garzón, Berta Sufrate-Vergara, Aasne K. Aarsand, Sverre Sandberg, Anna Carobene, Outi Itkonen, William Bartlett, Abdurrahman …
Read more Stability of serum metabolites following delayed centrifugationon March 31, 2026 at 6:16 am March 31, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Antonio Minò, Cristiana Tiberio, Marika Caruso, Alfonso Di Costanzo, Antonella Angiolillo
Current and Future Indication for Testing and Use of Cardiac Troponin in Children March 29, 2026 Clin Chem. 2026 Mar 27:hvag021. doi: 10.1093/clinchem/hvag021. Online ahead of print. ABSTRACT BACKGROUND: The clinical use and interpretation of cardiac troponins (cTn) in pediatric patients is heterogeneous. CONTENT: This review …
Read more Comparing the Efficiency of Bisulfite and Enzymatic DNA Methylation Conversion Methods for Detection of Colorectal Cancer Biomarkers March 29, 2026 Clin Chem. 2026 Mar 27:hvag018. doi: 10.1093/clinchem/hvag018. Online ahead of print. ABSTRACT BACKGROUND: Bisulfite conversion remains the gold standard method for DNA methylation analysis but has known limitations. Enzymatic conversion …
Read more Prospect of Improving Clinical Decisions Informed by Genetic Variations in the Population March 29, 2026 Clin Chem. 2026 Mar 27:hvag019. doi: 10.1093/clinchem/hvag019. Online ahead of print. NO ABSTRACT PMID:41894445 | DOI:10.1093/clinchem/hvag019
Exploring the stability of whole blood samples for remote health care applications towards reliable home-based blood testingM. H. Elise van Driel, Alan Han, Dirk J. Grünhagen, Christian Ramakers1Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands,2Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlandson February 3, 2026 at 1:41 am March 29, 2026 Annals of Clinical Biochemistry, Ahead of Print. ObjectivesTo evaluate the stability of commonly used biomarkers in whole blood under various storage conditions, in order to assess their suitability for home-based …
Read more Intraoperative tissue aspirate testing: A single-center experience and evaluation of criteria for parathyroid tissue confirmationon March 29, 2026 at 11:13 am March 29, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Jillian Kodger, Natalie Merchant, Joe M. El-Khoury, Jennifer B. Ogilvie, Adriana G. Ramirez, Thomas J.S. Durant
Metabolic and mitochondrial alterations in children with autism spectrum disorder: The role of FGF-21 and GDF-15on March 29, 2026 at 11:13 am March 29, 2026 Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Ayla Yildiz, Hanim Seyma Topuz, Hasan Onal
Preanalytical stability of zinc in whole blood serum and plasma tubes as measured by ICP-OES and colourimetryKristian Voss Bjerre, Helle Glud Binderup, Mads Nybo, Louise Helskov Jørgensen1Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark2Department of Clinical Biochemistry, 11286Odense University Hospital, Svendborg, Denmarkon September 16, 2025 at 6:36 am March 29, 2026 Annals of Clinical Biochemistry, Ahead of Print. BackgroundZinc deficiency is a global concern, particularly in low-income countries, but also among vulnerable groups in Western countries, such as children. Diagnosing mild …
Read more Predicting the outcome of short Synacthen test based on baseline cortisol levels: A single-centered retrospective cohort study at a tertiary care hospital in Sri LankaPremadasa T, Samarathunga EPA, Sujith EM, Shameela NMF, Basnayaka BMKS, Antonypillai CN, Jayawardana RDP1Department of Chemical Pathology, National Hospital, Kandy, Sri Lanka2Department of Quality Control, National Hospital, Kandy, Sri Lanka3Department of Diabetic and Endocrinology, National Hospital, Kandy, Sri Lankaon September 16, 2025 at 2:39 am March 29, 2026 Annals of Clinical Biochemistry, Ahead of Print. IntroductionShort Synacthen Test (SST), a standard diagnostic test to confirm Adrenal insufficiency (AI), involves substantial expenses.ObjectivesThis study aimed to assess the predictive value …
Read more Evaluation of a point of care prostate-specific antigen blood test on a mobile outreach serviceMasood Moghul, Helen Berry, Freeda Millet, Amina Tran, Fiona Mutch, Elizabeth Westaway, Fionnuala Croft, Robyn Shea, Netty Kinsella, Patrick Kierkegaard, Declan Cahill, Nicholas David James1Department of Urology, 4970The Royal Marsden NHS Foundation Trust, London, UK2Division of Radiotherapy and Imaging, 5053The Institute of Cancer Research, London, UK3Cancer Research UK Convergence Science Centre, 4615Imperial College London, London, UKon November 5, 2025 at 10:16 am March 29, 2026 Annals of Clinical Biochemistry, Ahead of Print. BackgroundPoint of care (POC) tests may improve accessibility and reduce costs of blood tests including in prostate cancer. The Man Van project was …
Read more Improving the PLASMIC score with the use of RDW-SD in the differential diagnosis for thrombotic thrombocytopenic purpura in Chinese patientsChi Zhang, Libo Xia, Xuesong Lv, Weixun Sun, Zhigang Xiong, Yang Fei1Department of Laboratory Medicine, 66375Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China2Department of Clinical Laboratory, Changyang Tujia Autonomous County People’s Hospital, Yichang, Chinaon December 15, 2025 at 5:42 am March 29, 2026 Annals of Clinical Biochemistry, Ahead of Print. BackgroundThis study aimed to identify laboratory parameters that could optimize the PLASMIC score, thereby improving its diagnostic accuracy for thrombotic thrombocytopenic purpura (TTP).MethodsWe …
Read more A UK & Ireland national audit of urine acidificationEmma Hughes, Louise Ward, Wassif S Wassif1Department of Clinical Biochemistry, 59633Aberdeen Royal Infirmary, Aberdeen, UK2On Behalf of the Association for Laboratory Medicine, National Clinical Biochemistry Audit Committee, London, UK3Department of Clinical Biochemistry, 575329Bedfordshire Hospitals NHS Foundation Trust, Bedford, UKon December 15, 2025 at 5:41 am March 29, 2026 Annals of Clinical Biochemistry, Ahead of Print. ObjectivesAcidification of urine samples has long been used as a method of preservation to enhance analyte stability. However, there are inherent safety risks …
Read more Enhancing laboratory quality through comprehensive risk management and process analysisShobha C Ramachandra, Venkatesha Madegowda, Manish Kumar Pandey, Akila Prashant, Kusuma K Shivashankar, Swetha N KempegowdaDepartment of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Indiaon February 3, 2026 at 1:34 am March 29, 2026 Annals of Clinical Biochemistry, Ahead of Print. BackgroundLaboratory test results are crucial for clinical decisions, but errors at any stage can compromise patient safety. Despite technological advances and quality systems, …
Read more Establishment of a candidate reference method and verification of reference intervals for serum copper in pregnant and non-pregnant womenMengyu Xu, YunGang Pu, Tianyue Zhang, Zhenni Liu, Qian Zhang, Weiyan Zhou, Yuhang Deng, Chao Zhang, Hao Zheng, Haijian Zhao, Jiangtao Zhang, Tianjiao Zhang, Jing Wang, Jie Zeng, Chuanbao Zhang1National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, P.R. China2Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China3Laboratory Department, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China4Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China5Department of Clinical Laboratory, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, Chinaon February 9, 2026 at 5:26 am March 29, 2026 Annals of Clinical Biochemistry, Ahead of Print. BackgroundSerum copper is an essential trace element, and accurate quantification is important for assessing copper status in pregnancy and supporting early clinical interventions. …
Read more CHI3L1 combined with Th17/Treg cells: a novel marker for the degree of HBV-related liver fibrosisHuiyuan Chen Qiuying Fan Wei Jiao Yuanfang Tan Xi Gou Weiming Yang Hui Liu Qiong Wu Juanjuan Chen Jiangxi Province Key Laboratory of Immunology and Inflammation, Jiangxi Provincial Clinical Research Center for Laboratory Medicine, Department of Clinical Laboratory, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, Chinaon March 9, 2026 at 2:58 am March 29, 2026 Volume 86, Issue 2, APRIL 2026, Page 198-207.
Detecting Siemens macrotroponin by a point of care high sensitivity troponin I assay: A first lookon March 29, 2026 at 11:13 am March 29, 2026 Publication date: June 2026 Source: Clinical Biochemistry, Volume 143 Author(s): Amir Karin
