An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of gentamicin in human serumJo Anne Wrighton August 18, 2026 at 10:00 am August 18, 2026 Clin Chem Lab Med. 2026 Aug 19. doi: 10.1515/cclm-2026-0593. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) of gentamicin is critical to ensure efficacy and minimize toxicity. We …
Read more Corrigendum to: T-cell receptor beta constant 1 flow cytometry for diagnosing clonality in mature T-cell neoplasms: a systematic review and meta-analysis of diagnostic accuracyPablo Adrian Biaggionion August 18, 2026 at 10:00 am August 18, 2026 Clin Chem Lab Med. 2026 Aug 14. doi: 10.1515/cclm-2026-1231. Online ahead of print. NO ABSTRACT PMID:42609098 | DOI:10.1515/cclm-2026-1231
Biological Variation of Adrenal-Related Endocrine Biomarkers Used for Investigation of Secondary Hypertension August 17, 2026 Clin Chem. 2026 Aug 17:hvag076. doi: 10.1093/clinchem/hvag076. Online ahead of print. ABSTRACT BACKGROUND: Adrenal-related biomarkers are central in evaluating endocrine causes of secondary hypertension, but their interpretation is influenced by …
Read more Detection of Multiple Medetomidine Metabolites in Clinical Urine Specimens by Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry (LC-qToF-MS) August 17, 2026 Clin Chem. 2026 Aug 17:hvag096. doi: 10.1093/clinchem/hvag096. Online ahead of print. NO ABSTRACT PMID:42606078 | DOI:10.1093/clinchem/hvag096
Independent internal quality control: an essential element of objective verification under ISO 15189:2022Oswald Sonntagon August 17, 2026 at 10:00 am August 17, 2026 Clin Chem Lab Med. 2026 Aug 18. doi: 10.1515/cclm-2026-1252. Online ahead of print. NO ABSTRACT PMID:42605536 | DOI:10.1515/cclm-2026-1252
Model 1b analytical performance specifications – report on the Prague 2025 workshopAndrea R Horvathon August 17, 2026 at 10:00 am August 17, 2026 Clin Chem Lab Med. 2026 Aug 18. doi: 10.1515/cclm-2026-1024. Online ahead of print. ABSTRACT The main purpose of establishing APS is to ensure that test performance aligns with their specific …
Read more Evaluating variability in 24-hour urine free cortisol measurements: impact of sample collection errorsÖmer Özcanon August 16, 2026 at 10:00 am August 16, 2026 Clin Chem Lab Med. 2026 Aug 17. doi: 10.1515/cclm-2026-0410. Online ahead of print. ABSTRACT OBJECTIVES: 24 hour urine free cortisol measurement is widely used for screening Cushing’s syndrome, but its …
Read more A 4-year-old male presenting with frequent falls, clumsily rising from seated positions, but a normal creatine kinaseon August 15, 2026 at 12:02 pm August 15, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Jude Abadie
Effect of the unreported COL5A2 variant c.2499 + 4_2499 + 5insTAA on RNA splicing: Insights from minigene assayson August 15, 2026 at 12:02 pm August 15, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Zhongying Zhao, Lianrui Tang, Jing Zhu, Bingbo Zhou, Xinyuan Tian, Yupei Wang, Furong Liu, Hairui Pan, Ling Hui, …
Read more A step forward in the harmonization of tests for the hypothalamus-pituitary-adrenal axis function: the Netherland modelLaura Rotoloon August 14, 2026 at 10:00 am August 14, 2026 Clin Chem Lab Med. 2026 Aug 17. doi: 10.1515/cclm-2026-1290. Online ahead of print. NO ABSTRACT PMID:42598804 | DOI:10.1515/cclm-2026-1290
Lipoprotein X as a source of analytical and interpretative interference in routine laboratory testingShanshan Liangon August 14, 2026 at 10:00 am August 14, 2026 Clin Chem Lab Med. 2026 Aug 17. doi: 10.1515/cclm-2026-0950. Online ahead of print. ABSTRACT Lipoprotein X (LpX) is an abnormal lipoprotein-like particle occurring mainly in cholestasis, lecithin-cholesterol acyltransferase deficiency, post-transplant …
Read more Does the use of nephelometrically measured albumin enhance the accuracy of adjusted calcium performance in CKD patients?Nuthar Jassamon August 14, 2026 at 10:00 am August 14, 2026 Clin Chem Lab Med. 2026 Aug 17. doi: 10.1515/cclm-2026-0979. Online ahead of print. NO ABSTRACT PMID:42596680 | DOI:10.1515/cclm-2026-0979
Two CCLM papers: different routes, common goalsDavid Housleyon August 13, 2026 at 10:00 am August 13, 2026 Clin Chem Lab Med. 2026 Aug 14. doi: 10.1515/cclm-2026-1240. Online ahead of print. NO ABSTRACT PMID:42592658 | DOI:10.1515/cclm-2026-1240
Analytically accurate, clinically inaccurate: A diagnostic case of Pseudohyperparathyroidismon August 13, 2026 at 4:15 pm August 13, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Chelsea B. Swartchick, Jodi L. Boysen, Ryan W. Pearce, Nikola A. Baumann, Brooke M. Katzman
Procalcitonin measurement uncertainty around Sepsis-related decision thresholds: Monte Carlo modeling from a large-scale clinical laboratory dataseton August 13, 2026 at 4:15 pm August 13, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Beyza Haytaç, Gamze Gök, Özcan Erel, Ceylan Bal
A liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of vancomycin in human serum and plasmaSandra Fleischeron August 11, 2026 at 10:00 am August 11, 2026 Clin Chem Lab Med. 2026 Aug 12. doi: 10.1515/cclm-2026-0509. Online ahead of print. ABSTRACT OBJECTIVES: Vancomycin is a glycopeptide antibiotic used to treat severe Gram-positive infections; its narrow therapeutic window …
Read more Clinical chemistry reference intervals in clinically validated healthy individuals: A large single-center studyon August 11, 2026 at 2:02 pm August 11, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Rob F.M. Oude Elferink, Shirly A.M. Wübbels, Geert Sloots, Anja Koster, Jan Leendert P. Brouwer
Integrated DIA proteomics of tissue and exudate reveals screening markers for early detection of ulcerative colitis and colorectal canceron August 11, 2026 at 2:02 pm August 11, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Qian Gong, Jin Wang, Qing Ke, Shuangshuang Du, Sinian Huang, Ting Zhu, Hao Qu, Ran Xu, Jiandong Zhang, …
Read more Harmonizing M-protein analysis: an international, multi-center reproducibility study of mass spectrometry and evaluation of concordance to electrophoretic methodsKatie Thorenon August 10, 2026 at 10:00 am August 10, 2026 Clin Chem Lab Med. 2026 Aug 11. doi: 10.1515/cclm-2026-0844. Online ahead of print. ABSTRACT OBJECTIVES: Serum M-protein analysis is central to the assessment of monoclonal gammopathies. Quantitation and isotyping are …
Read more Reply to Sorigue and Petriz: TRBC1 flow cytometry retains high sensitivity and a low negative likelihood ratio, whereas rule-in interpretation remains context-dependentPablo Adrian Biaggionion August 10, 2026 at 10:00 am August 10, 2026 Clin Chem Lab Med. 2026 Aug 11. doi: 10.1515/cclm-2026-1221. Online ahead of print. NO ABSTRACT PMID:42573469 | DOI:10.1515/cclm-2026-1221
Internal fluidic system contamination associated with falsely increased magnesium results on a Roche Cobas c303 analyzerRaffick A R Bowenon August 10, 2026 at 10:00 am August 10, 2026 Clin Chem Lab Med. 2026 Aug 11. doi: 10.1515/cclm-2026-0946. Online ahead of print. NO ABSTRACT PMID:42573468 | DOI:10.1515/cclm-2026-0946
Therapeutic monoclonal antibodies mimicking paraproteins in immunofixation electrophoresis: migration profiles of 21 commonly used agentsMarie-Léa Kabouon August 10, 2026 at 10:00 am August 10, 2026 Clin Chem Lab Med. 2026 Aug 11. doi: 10.1515/cclm-2026-0777. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic monoclonal antibodies (t-mAbs) are increasingly used in oncology, hematology, autoimmune diseases, and inflammatory disorders. …
Read more P-homocysteine adjusted for estimated glomerular filtration rateArne Åsbergon August 7, 2026 at 10:00 am August 7, 2026 Clin Chem Lab Med. 2026 Aug 10. doi: 10.1515/cclm-2026-1172. Online ahead of print. NO ABSTRACT PMID:42565393 | DOI:10.1515/cclm-2026-1172
An accessible digital single-molecule sensing platform for plasma P-tau217 quantification in Alzheimer’s disease screeningon August 7, 2026 at 9:57 am August 7, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Meng Xue, Hongchao Pan, Yana He, Haiyan Li, Hailan Zhou, Keding Cheng, ChuangChuang Xiao, Jie Zhao, Xiaodong Jia, …
Read more IOF-IFCC international survey of global laboratory practices for bone status indicesEtienne Cavalieron August 6, 2026 at 10:00 am August 6, 2026 Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-0941. Online ahead of print. ABSTRACT OBJECTIVES: Bone status indices (BSIs) are increasingly used in metabolic bone disease, yet global laboratory practices …
Read more Sustainability comparison of three clinical laboratory analytical systems in SpainAntonio Fernández Suárezon August 6, 2026 at 10:00 am August 6, 2026 Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-0817. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratories face growing demands to balance healthcare needs with cost and resource efficiency. Solutions …
Read more Dried blood microsampling: a tool to mitigate the post-sampling formation of 11-ketotestosterone in blood?Hanna De Baetson August 6, 2026 at 10:00 am August 6, 2026 Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-1084. Online ahead of print. NO ABSTRACT PMID:42559829 | DOI:10.1515/cclm-2026-1084
Unified definition of integrated diagnostics: a position statement of the EFLMJochen K Lennerzon August 6, 2026 at 10:00 am August 6, 2026 Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-0949. Online ahead of print. ABSTRACT Integrated diagnostics is an emerging multidisciplinary model of care that integrates traditionally siloed domains, including pathology, …
Read more The utilization of multiplex PCR with fragment analysis for carrier screening of spinal muscular atrophyon August 6, 2026 at 3:01 pm August 6, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Kunvara Orachon, Watcharapa Jaranasaksakul, Preyaporn Onsod, Teerapong Siriboonpiputtana, Budsaba Rerkamnuaychoke, Takol Chareonsirisuthigul
From analytical bias to threshold-based discordance: An ID-LC-MS/MS reference method reveals and corrects hyperhomocysteinemia classification discordance in Chinaon August 6, 2026 at 3:01 pm August 6, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Kaiduo Xu, Yunmiao Sun, Xuanchang Bai, Jing Wang, Jiangtao Zhang, Haijian Zhao, Weiyan Zhou, Chuanbao Zhang
An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of meropenem in human serum and plasmaRupert Schmidon August 5, 2026 at 10:00 am August 5, 2026 Clin Chem Lab Med. 2026 Aug 6. doi: 10.1515/cclm-2026-0428. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) of meropenem is critical for optimizing clinical efficacy and minimizing toxicity. …
Read more Diagnostic performance and interference analysis of a chemiluminescent H. pylori stool antigen assay stratified by 13C-urea breath test values in a multicenter studyon August 5, 2026 at 1:37 pm August 5, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Zixia Wang, Xiaozhong Chen, Huiqiong Lu, Qianyun Deng, Liuqin Chen, Yue Meng, Beibei Wang, Lei Wang, Wei Fang …
Read more Transferrin-derived TIBC, a flagged but normal resulton August 5, 2026 at 1:37 pm August 5, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Martin Safran, James Corines, Matthew Elkins, Michel R. Nasr, Katalin Banki, Zhimin Tim Cao
Enriching Microbial Cell-Free DNA in Clinical Metagenomics Using Epigenetic Filters August 5, 2026 Clin Chem. 2026 Aug 5:hvag089. doi: 10.1093/clinchem/hvag089. Online ahead of print. ABSTRACT INTRODUCTION: Noninvasive cell-free DNA (cfDNA) metagenomic sequencing enables hypothesis-free detection of microbial pathogens in patients with suspected infections. …
Read more APOB to Estimated APOB Ratio for Screening for the APOE2 Genotype August 3, 2026 Clin Chem. 2026 Aug 3:hvag094. doi: 10.1093/clinchem/hvag094. Online ahead of print. ABSTRACT BACKGROUND: Familial dysbetalipoproteinemia (FDB) is a genetic lipoprotein disorder that can develop in patients homozygous for the apolipoprotein …
Read more Commentary on When Is Apparent Hemoglobin S Trait Something More Complex? August 3, 2026 Clin Chem. 2026 Aug 3;72(8):830. doi: 10.1093/clinchem/hvag073. NO ABSTRACT PMID:42545161 | DOI:10.1093/clinchem/hvag073
Supercharged Measured GFR in a 15-Year-Old August 3, 2026 Clin Chem. 2026 Aug 3;72(8):911. doi: 10.1093/clinchem/hvag049. NO ABSTRACT PMID:42545160 | DOI:10.1093/clinchem/hvag049
Commentary on When Is Apparent Hemoglobin S Trait Something More Complex? August 3, 2026 Clin Chem. 2026 Aug 3;72(8):828-829. doi: 10.1093/clinchem/hvag065. NO ABSTRACT PMID:42545159 | DOI:10.1093/clinchem/hvag065
When Is Apparent Hemoglobin S Trait Something More Complex? August 3, 2026 Clin Chem. 2026 Aug 3;72(8):824-828. doi: 10.1093/clinchem/hvag060. NO ABSTRACT PMID:42545158 | DOI:10.1093/clinchem/hvag060
Mapping pediatric cardiac troponin testing worldwide: results from the IFCC survey on emerging applications, standardization needs and accessCatherine L Omosuleon August 3, 2026 at 10:00 am August 3, 2026 Clin Chem Lab Med. 2026 Aug 4. doi: 10.1515/cclm-2026-0711. Online ahead of print. ABSTRACT OBJECTIVES: Limited guidance on the use and interpretation of cardiac troponin (cTn) testing in pediatric populations …
Read more Microwave-assisted hydrolysis and HPAEC-PAD for simultaneous quantification of sialic acid and six other glycan monosaccharides in human serum: RSM optimization, validation, and proof-of-concept application to acute strokeon August 2, 2026 at 5:00 pm August 2, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Meng Zhang, Lijuan Zhang, Hong Lu, Yiran Zhang
Continuous reference curves for hematology and biochemistry analytes in pregnancy – a prospective studyVesna Šupak-Smolčićon August 1, 2026 at 10:00 am August 2, 2026 Clin Chem Lab Med. 2026 Aug 3. doi: 10.1515/cclm-2026-0609. Online ahead of print. ABSTRACT OBJECTIVES: Pregnancy involves dynamic metabolic changes that cannot be accurately interpreted using population reference intervals (RI). …
Read more Bis(monoacylglycero)phosphate (BMP) as a circulating biomarker of lysosomal dysfunction in GNE myopathyon August 1, 2026 at 10:17 am August 1, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Cristina Manis, Fabrizio Pertusati, James Morewood, Andreas Roos, Felix Kleefeld, Michela Onali, Oksana Pogoryelova, Alexa Derksen, Sally Spendiff, …
Read more Application-related patterns of diluted urine specimens in routine urine drug testing: A retrospective specimen-record-level studyon August 1, 2026 at 10:17 am August 1, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Mehmet Akif Bozdayi, Gökhan Çakırca, İsmet Gamze Bozdayi
Red blood cell subpopulation ratios identify samples at risk of dipstick–flow cytometry hematuria discordance in Sysmex UN-Series analyzerson July 31, 2026 at 10:40 am July 31, 2026 Publication date: September 2026 Source: Practical Laboratory Medicine, Volume 51 Author(s): Jordi Tortosa-Carreres, Nahúm Martí-Montoro, Miguel Rodríguez-Manotas, Begoña Laiz-Marro
Short-term storage of pediatric cerebrospinal fluid and serum requires standardized handling to preserve neurological injury biomarker stabilityon July 31, 2026 at 10:40 am July 31, 2026 Publication date: October 2026 Source: Clinical Biochemistry, Volume 145 Author(s): Natalia García-Sancha, Juan Valencia-Ramos, Simón Gundín-Menéndez, María Martín-Palencia, María Miranda-Vega, Sara Calvo-Simal, Juan Arnáez
Diagnostic pitfall: NSAID-induced membranous nephropathy with PLA2R positivity, IgG1-predominant deposits, C1q positivity, and concurrent acute interstitial nephritis—A case reporton July 30, 2026 at 2:48 pm July 30, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Jingzhen Li, Qianqian Zhang, Zhengyue Chen, Yingyin Qiu, Yuanping Liu
Advanced algorithm for correcting cold agglutination interference in red blood cell parameters with the Mindray BC-7600 hematology analyzeron July 30, 2026 at 2:48 pm July 30, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Bo Ye, Jiong Zhang, Wenbo Zheng, Danzhou Tao, Zhongfu Zhang, Yushuai Ma, Taiqiang Zhao
Development of a liquid chromatography coupled to tandem mass spectrometry method for the quantification of Arginine Vasopressin in human plasmaon July 30, 2026 at 2:48 pm July 30, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): E. Grifnée, E. Cavalier, C. Le Goff
Highly Accurate Sequencing Methods for Low-Frequency Variant Detection July 29, 2026 Clin Chem. 2026 Jul 29:hvag074. doi: 10.1093/clinchem/hvag074. Online ahead of print. ABSTRACT BACKGROUND: Next-generation sequencing (NGS), also known as massively parallel sequencing, has become an essential tool across many areas …
Read more Specific serum metabolites can differentiate severe and mild human traumatic brain injuryon July 29, 2026 at 2:06 pm July 29, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Lei Shi, Zhuonan Wang, Jie Zhang, Ping Zheng, Lijun Bai
Reduced fecal GP2 levels in ulcerative colitis associate with inflammatory activity and microbial compositionon July 29, 2026 at 2:06 pm July 29, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Yoav Uchitel, Dirk Roggenbuck, Haim Leibovitzh, Nathaniel Aviv Cohen, Rony Izhar, Lior Lobel, Nitsan Maharshak, Lael Werner
Automated detection of intravenous fluid contamination using longitudinal routine laboratory data: development and external validation of a multitask learning frameworkon July 29, 2026 at 2:06 pm July 29, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Jordi Tortosa-Carreres, Nahúm Martí-Montoro, Jonnathan Andrés Acevedo-Galvis, Cristel Pascual-Escrivà, Ricardo Alonso-Díaz, Óscar Fuster-Lluch, Laura Sahuquillo-Frias, Begoña Laiz-Marro
Proposed laboratory diagnostic workflow in the Italian national screening program for type 1 diabetesLucia Babinion July 29, 2026 at 10:00 am July 29, 2026 Clin Chem Lab Med. 2026 Jul 30. doi: 10.1515/cclm-2026-0536. Online ahead of print. ABSTRACT Population screening for type 1 diabetes (T1D) using pancreatic islet autoantibodies is increasingly recognized as a …
Read more The severity of harm score database: an evidence-based foundation for laboratory test risk analysisHikmet Can Çubukçuon July 28, 2026 at 10:00 am July 28, 2026 Clin Chem Lab Med. 2026 Jul 29. doi: 10.1515/cclm-2026-0875. Online ahead of print. ABSTRACT BACKGROUND: Patient risk management has become central to clinical laboratory quality standards, including the Clinical and …
Read more Performance validation of mass spectrometry for detecting urinary Bence Jones protein and evaluation of its clinical application in multiple myeloma and amyloidosisYu Chenon July 28, 2026 at 10:00 am July 28, 2026 Clin Chem Lab Med. 2026 Jul 29. doi: 10.1515/cclm-2026-0469. Online ahead of print. ABSTRACT OBJECTIVES: Traditional urine immunofixation electrophoresis (uIFE) is cumbersome, has limited sensitivity, and is subjectively interpreted. This …
Read more Extremely high follicle-stimulating hormone with normal ovarian functionon July 28, 2026 at 2:03 pm July 28, 2026 Publication date: October 2026 Source: Clinical Biochemistry, Volume 145 Author(s): Yu Chen, Jana Bubar, Chelsey Flemming, Ihssan Bouhtiauy
Improving the performance of biochemical genetic testing through external quality assessmentKatrin Freiburghauson July 28, 2026 at 10:00 am July 28, 2026 Clin Chem Lab Med. 2026 Jul 29. doi: 10.1515/cclm-2026-0815. Online ahead of print. ABSTRACT OBJECTIVES: External quality assessment (EQA) is essential for ensuring reliable biochemical genetic testing. This study evaluated …
Read more Prospective evaluation of a multi-gene cfDNA methylation assay for CRC screening in a high-risk cohortYing Lion July 28, 2026 at 10:00 am July 28, 2026 Clin Chem Lab Med. 2026 Jul 29. doi: 10.1515/cclm-2026-0185. Online ahead of print. ABSTRACT OBJECTIVES: Colorectal cancer (CRC) screening is crucial for early detection, yet the invasiveness of the gold-standard …
Read more Is Tau Acetylation a Key to Frontotemporal Lobar Degeneration Diagnosis? July 27, 2026 Clin Chem. 2026 Jul 27:hvag090. doi: 10.1093/clinchem/hvag090. Online ahead of print. NO ABSTRACT PMID:42504910 | DOI:10.1093/clinchem/hvag090
Keeping It under Control: Developing Reference Materials during a Rapidly Evolving Arboviral Outbreak July 27, 2026 Clin Chem. 2026 Jul 27:hvag095. doi: 10.1093/clinchem/hvag095. Online ahead of print. NO ABSTRACT PMID:42504912 | DOI:10.1093/clinchem/hvag095
Evaluating Cobas® b101 for lipid profile and SCORE2 risk assessment from capillary blood in population screeningAntoine Villeminon July 27, 2026 at 10:00 am July 27, 2026 Clin Chem Lab Med. 2026 Jul 28. doi: 10.1515/cclm-2026-0570. Online ahead of print. ABSTRACT OBJECTIVES: Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Emerging lung cancer screening in …
Read more The ISO 15189-IVDR dilemma in medical laboratory practiceIheb Elkaibion July 27, 2026 at 10:00 am July 27, 2026 Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0864. Online ahead of print. ABSTRACT INTRODUCTION: To analyse the structural and operational divergences between NF EN ISO 15189:2022 and Regulation (EU) …
Read more Risk outcome assessment with novel long-T ITC complex and high sensitivity troponin I and T in patients with suspected acute coronary syndromes: MERITnI substudyFred S Appleon July 26, 2026 at 10:00 am July 26, 2026 Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0790. Online ahead of print. ABSTRACT OBJECTIVES: Understanding whether the novel long-T ITC complex might assist in interpreting clinical prognostic utility compared …
Read more An ID-HPLC-MS/MS based candidate reference measurement procedure for the quantification of ceramides in human serumon July 26, 2026 at 11:38 am July 26, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Huoyan Ji, Xiaozhen Zhang, Xiaofan Yin, Xiaodong Yang, Weiming He, Min Shen
Multiplex methylation marker analysis for ctDNA detection in liquid biopsies from anal cancer patients: an HPV-independent approachon July 25, 2026 at 10:42 am July 25, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Søren Kahns, Luisa M.D. Canto, Laura E. Stokkebro, Jonna S. Madsen, Renske D.M. Steenbergen, Jan Lindebjerg, Claus Varnum, …
Read more Pheochromocytoma as a manifestation of Neurofibromatosis type 1: Clinical presentation, diagnosis, and genetic analysison July 25, 2026 at 10:42 am July 25, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Neus Baena-Díez, Ruth Cano-Corres, Elisabet Castellanos, Josep Leon Mengibar, Ismael Capel Flores
Hyperuricemia, circulating metabolites, and the risk of cardiometabolic multimorbidityon July 24, 2026 at 3:42 pm July 24, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Ziyi Zhou, Yin Wu, Yuan Fei, Jiaheng Chu, Shuo Jiang, Weisheng Xu, Xiaoqi Zheng, Hui Wang
Association of the triglyceride-glucose index with tumor burden in newly diagnosed multiple myeloma: A retrospective cross-sectional studyon July 24, 2026 at 3:42 pm July 24, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Jing Zhang, Dan Xu, Ran Luo, Wentao Shu, Dongfeng Zeng, Xiaona Bu
The BV calculator: a free, open-source web app for estimation of within-subject and between-subject biological variationHikmet Can Çubukçuon July 24, 2026 at 10:00 am July 24, 2026 Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0863. Online ahead of print. ABSTRACT OBJECTIVES: Biological variation (BV) data are essential for many purposes in laboratory medicine, however, the complex …
Read more Pediatric reference intervals for 27 routine chemistry analytes in healthy children and adolescents on the Roche cobas pro platformBenjamin Jungon July 24, 2026 at 10:00 am July 24, 2026 Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0627. Online ahead of print. ABSTRACT OBJECTIVES: Accurate interpretation of pediatric laboratory test results requires robust age- and sex-specific reference intervals (RIs). …
Read more On repeating out-of-control quality control measurements in medical laboratoriesOswald Sonntagon July 23, 2026 at 10:00 am July 24, 2026 Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0926. Online ahead of print. NO ABSTRACT PMID:42492590 | DOI:10.1515/cclm-2026-0926
Laboratory medicine 2050: from testing to health intelligence network, a vision from the IFCC Emerging Technologies DivisionDamien Grusonon July 23, 2026 at 10:00 am July 24, 2026 Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0903. Online ahead of print. ABSTRACT Laboratory medicine is undergoing a profound transformation driven by advances in artificial intelligence (AI), automation, and …
Read more Application of blood rheology to develop hemolysis-free serum extraction sampling method for small-volume bloodon July 23, 2026 at 9:52 am July 23, 2026 Publication date: Available online 22 July 2026 Source: Practical Laboratory Medicine Author(s): Hideaki Isago, Baasanjav Uranbileg, Keisuke Murayama, Yuki Nakano, Yukio Kume, Yoshihiro Minagawa, Masaomi Nangaku, Hiroyuki Noji, Makoto Kurano
Serum hCG reference values in menopausal women across four immunoassay platforms: implications of renal function for clinical interpretationDiane Bavouxon July 22, 2026 at 10:00 am July 22, 2026 Clin Chem Lab Med. 2026 Jul 23. doi: 10.1515/cclm-2026-0704. Online ahead of print. ABSTRACT OBJECTIVES: Most available data on human chorionic gonadotropin (hCG) elevations in menopausal women are derived from …
Read more Evaluation of the Sysmex UC-1000 test strip reader: fit for purpose in a point-of-care setting?Jana Neirinckon July 22, 2026 at 10:00 am July 22, 2026 Clin Chem Lab Med. 2026 Jul 23. doi: 10.1515/cclm-2026-0866. Online ahead of print. ABSTRACT OBJECTIVES: Urinalysis is essential for detecting kidney disease, urinary tract infections, and diabetes mellitus. Point-of-care testing …
Read more Urine culture contamination in a tertiary hospital: Demographic predictors and direct economic impacton July 22, 2026 at 2:21 pm July 22, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Marcos Palma-Lopez, Luis Roberto Galindo-Mendez
Choosing Wisely – avoiding medical overuse: evidence assessment of recommendations on laboratory parametersCihan Berion July 21, 2026 at 10:00 am July 21, 2026 Clin Chem Lab Med. 2026 Jul 21. doi: 10.1515/cclm-2026-0358. Online ahead of print. ABSTRACT OBJECTIVES: Launched in 2012, the Choosing Wisely initiative promotes evidence-based recommendations to reduce unnecessary tests and …
Read more From hospital care to home: bringing laboratory-led POCT to home care for sodium monitoring in pediatric patients with craniopharyngiomaIsabel Moreno-Parroon July 21, 2026 at 10:00 am July 21, 2026 Clin Chem Lab Med. 2026 Jul 22. doi: 10.1515/cclm-2026-0922. Online ahead of print. NO ABSTRACT PMID:42478752 | DOI:10.1515/cclm-2026-0922
Transfusion-dependent changes to hemoglobin A1c in a beta-thalassemia major patientCelina Phanon July 21, 2026 at 10:00 am July 21, 2026 Clin Chem Lab Med. 2026 Jul 22. doi: 10.1515/cclm-2026-0935. Online ahead of print. NO ABSTRACT PMID:42478228 | DOI:10.1515/cclm-2026-0935
The hidden cost of preanalytical errors in a tertiary care hospital laboratoryIbrahim Yangınon July 21, 2026 at 10:00 am July 21, 2026 Clin Chem Lab Med. 2026 Jul 22. doi: 10.1515/cclm-2026-1026. Online ahead of print. NO ABSTRACT PMID:42478225 | DOI:10.1515/cclm-2026-1026
A novel urinary metabolic signature for the non-invasive screening of lupus nephritis in systemic lupus erythematosuson July 20, 2026 at 12:02 pm July 20, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Zhifang Yao, Ping Yang, Xiang Qian
Predictive value of serum biomarkers for first trimester prediction of preterm prelabour rupture of membranes (PPROM): a systematic review and meta-analysisMarion Rouzaireon July 20, 2026 at 10:00 am July 20, 2026 Clin Chem Lab Med. 2026 Jul 21. doi: 10.1515/cclm-2026-0380. Online ahead of print. ABSTRACT INTRODUCTION: The identification of early biomarkers is a critical prerequisite for the development and optimization of …
Read more Integrated genomic and biochemical diagnosis of a novel homozygous start-loss variant in AKR1D1 associated with neonatal cholestasison July 19, 2026 at 2:31 pm July 19, 2026 Publication date: October 2026 Source: Clinical Biochemistry, Volume 145 Author(s): Alberto Izquierdo-Martínez, Jose Luis Rubio-Prieto, Ana Rodriguez-Rodriguez, Zoraima Martínez-Martos, Carmen Delgado-Pecellín
Investigating non-reproducible high-sensitivity cardiac troponin T results in real-world practiceon July 19, 2026 at 11:30 am July 19, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Zeynep Şule Evren, Kamil Taha Uçar
Urine Immunoglobulin Light Chain Fragments Detected by MALDI-TOF Mass Spectrometry July 18, 2026 Clin Chem. 2026 Jul 17:hvag085. doi: 10.1093/clinchem/hvag085. Online ahead of print. NO ABSTRACT PMID:42467676 | DOI:10.1093/clinchem/hvag085
Prognostic Value of Cardiac Myosin Binding Protein C in the General Population: The Akershus Cardiac Examination 1950 Study July 18, 2026 Clin Chem. 2026 Jul 17:hvag082. doi: 10.1093/clinchem/hvag082. Online ahead of print. ABSTRACT BACKGROUND: Cardiac myosin binding protein C (cMyC) is a cardiac-specific biomarker that is released after acute ischemic myocardial …
Read more Reference interval evolution: what moving to the 99th percentile looks like for a comprehensive metabolic panel in an outpatient settingon July 17, 2026 at 12:34 pm July 17, 2026 Publication date: October 2026 Source: Clinical Biochemistry, Volume 145 Author(s): Jillian Kodger, Joe M. El-Khoury
Plasma nerve growth factor level is associated with functional outcome after ischemic strokeon July 17, 2026 at 9:31 am July 17, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Yiming Jia, Lulu Sun, Mengyao Shi, Daoxia Guo, Yanbo Peng, Tan Xu, Yonghong Zhang, Zhengbao Zhu
Prospective real-time implementation and verification of patient-based real-time quality control using average of normals in a tertiary hospital laboratorySe-Eun Kooon July 16, 2026 at 10:00 am July 16, 2026 Clin Chem Lab Med. 2026 Jul 17. doi: 10.1515/cclm-2026-0201. Online ahead of print. ABSTRACT OBJECTIVES: Practical implementation of patient-based real-time quality control (PBRTQC) requires analyte- and institution-specific optimization. This study …
Read more Reply to Biaggioni and Gonzalez: Multidomain instability limits pooled diagnostic accuracy estimates for TRBC1-flow cytometryMarc Sorigueon July 16, 2026 at 10:00 am July 16, 2026 Clin Chem Lab Med. 2026 Jul 17. doi: 10.1515/cclm-2026-0984. Online ahead of print. NO ABSTRACT PMID:42461150 | DOI:10.1515/cclm-2026-0984
Integrating lung microbiome, amino acid metabolism, and host immune response in elderly patients for severe lower respiratory Infections diagnosis: a multi-omics studyon July 16, 2026 at 2:40 pm July 16, 2026 Publication date: 1 January 2027 Source: Clinica Chimica Acta, Volume 592 Author(s): Tianqi Qi, Qian Liu, Manyu Li, Haoyang Li, Guowei Liang, Wenjun Tu
Establishment and validation of intelligent review rules for blood cell analysis based on the gradient boosting decision tree algorithmon July 16, 2026 at 2:40 pm July 16, 2026 Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Wenjia Tang, Shaoqian Chen, Zhenglin Yu, Xiumei Gu, Baishen Pan, Beili Wang, Rong Ding, Shihong Zhang, Chong Wang, …
Read more Establishment of DBS-based reference intervals for vitamins, essential elements, and potentially toxic elements in Chinese adults from Hubei ProvinceMengtong Yangon July 15, 2026 at 10:00 am July 16, 2026 Clin Chem Lab Med. 2026 Jul 16. doi: 10.1515/cclm-2026-0511. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to establish a comprehensive panel of dried blood spot (DBS)-specific reference intervals …
Read more Precision Medicine for Lipids: The New US Guidelines for Dyslipidemia July 15, 2026 Clin Chem. 2026 Jul 15:hvag083. doi: 10.1093/clinchem/hvag083. Online ahead of print. NO ABSTRACT PMID:42455123 | DOI:10.1093/clinchem/hvag083
Characterization of the Migration Profile of 36 Therapeutic Monoclonal Antibodies in Serum Protein Electrophoresis and Immunofixation July 15, 2026 Clin Chem. 2026 Jul 15:hvag080. doi: 10.1093/clinchem/hvag080. Online ahead of print. ABSTRACT BACKGROUND: Therapeutic monoclonal antibodies (t-mAbs) are widely used in oncology, hematology, and immune-mediated diseases. Some t-mAbs are detectable …
Read more A markedly increased CK-MB relative index suggests a skeletal muscle contribution to re-elevated troponin T in immune checkpoint inhibitor-associated myositisYoko Usamion July 15, 2026 at 10:00 am July 15, 2026 Clin Chem Lab Med. 2026 Jul 16. doi: 10.1515/cclm-2026-0936. Online ahead of print. NO ABSTRACT PMID:42453044 | DOI:10.1515/cclm-2026-0936
Venous-capillary blood agreement for routine chemistry analytes: effects of collection site and sample matrixSara Dezaon July 14, 2026 at 10:00 am July 14, 2026 Clin Chem Lab Med. 2026 Jul 15. doi: 10.1515/cclm-2026-0671. Online ahead of print. ABSTRACT OBJECTIVES: Capillary blood sampling enables minimally invasive testing and decentralized workflows, but interchangeability with venous specimens …
Read more Chemometric profiling reveals selective circulating bile acid remodeling in Alzheimer’s diseaseon July 14, 2026 at 12:03 pm July 14, 2026 Publication date: 1 January 2027 Source: Clinica Chimica Acta, Volume 592 Author(s): M. Emam, Fatema S. Alatawi, Yasser Alzamil, Nisreen Haj, Amani A. Mahbub, Amna Mohamed Ahmed, Sara Albadri, Malik …
Read more Flow cytometric analysis of peritoneal dialysis fluid in suspected peritonitis: diagnostic performance and limitationsLea Tybirkon July 13, 2026 at 10:00 am July 14, 2026 Clin Chem Lab Med. 2026 Jul 14. doi: 10.1515/cclm-2026-0684. Online ahead of print. ABSTRACT OBJECTIVES: Peritonitis is a feared complication to peritoneal dialysis (PD), requiring empirical broad-spectrum antibiotics. A rapid …
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